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    Rnf139 ring finger protein 139 [ Mus musculus (house mouse) ]

    Gene ID: 75841, updated on 23-Jun-2021

    Summary

    Official Symbol
    Rnf139provided by MGI
    Official Full Name
    ring finger protein 139provided by MGI
    Primary source
    MGI:MGI:1923091
    See related
    Ensembl:ENSMUSG00000037075
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4930555P18Rik
    Expression
    Broad expression in testis adult (RPKM 73.5), liver E14 (RPKM 11.8) and 24 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Rnf139 in Genome Data Viewer
    Location:
    15; 15 D1
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (58760975..58774239)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (58889229..58902390)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (58720784..58733945)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene tRNA methyltransferase 12 Neighboring gene predicted gene, 36509 Neighboring gene TatD DNase domain containing 1 Neighboring gene NADH:ubiquinone oxidoreductase subunit B9 Neighboring gene MTSS I-BAR domain containing 1 Neighboring gene RIKEN cDNA 4930544F09 gene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protease binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ubiquitin-like protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in ERAD pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of translation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein destabilization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of ER to Golgi vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of protein processing ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of Derlin-1 retrotranslocation complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase RNF139
    Names
    RING-type E3 ubiquitin transferase RNF139
    translocation in renal carcinoma on chromosome 8 protein
    NP_780435.1
    XP_017172276.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175226.4NP_780435.1  E3 ubiquitin-protein ligase RNF139

      See identical proteins and their annotated locations for NP_780435.1

      Status: VALIDATED

      Source sequence(s)
      AK029069, AK033506, CJ180442
      Consensus CDS
      CCDS27494.1
      UniProtKB/Swiss-Prot
      Q7TMV1
      UniProtKB/TrEMBL
      A0A0R4J0K8
      Related
      ENSMUSP00000046467.7, ENSMUST00000036904.7
      Conserved Domains (3) summary
      cd00162
      Location:547589
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      pfam12678
      Location:544586
      zf-rbx1; RING-H2 zinc finger
      pfam13705
      Location:19516
      TRC8_N; TRC8 N-terminal domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      58760975..58774239
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017316787.3XP_017172276.1  E3 ubiquitin-protein ligase RNF139 isoform X1

      Conserved Domains (2) summary
      cd16683
      Location:465506
      RING-H2_RNF139; RING finger, H2 subclass, found in RING finger protein 139 (RNF139) and similar proteins
      pfam13705
      Location:5436
      TRC8_N; TRC8 N-terminal domain
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