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    Wrnip1 Werner helicase interacting protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 78903, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Wrnip1provided by MGI
    Official Full Name
    Werner helicase interacting protein 1provided by MGI
    Primary source
    MGI:MGI:1926153
    See related
    Ensembl:ENSMUSG00000021400 AllianceGenome:MGI:1926153
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    WHIP; Wrnip; 4833444L21Rik
    Summary
    Predicted to enable several functions, including ATP hydrolysis activity; identical protein binding activity; and single-stranded DNA helicase activity. Predicted to be involved in cellular macromolecule biosynthetic process and regulation of DNA metabolic process. Predicted to act upstream of or within DNA repair; DNA replication; and innate immune response. Located in nucleus. Is expressed in several structures, including alimentary system; cranial ganglion; cranium; limb; and naris. Orthologous to human WRNIP1 (WRN helicase interacting protein 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in ovary adult (RPKM 30.0), adrenal adult (RPKM 23.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    13 A3.2; 13 13.74 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (32986013..33006593)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (32802030..32822610)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_34101 Neighboring gene predicted gene, 40876 Neighboring gene myosin light chain kinase family, member 4 Neighboring gene serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene Neighboring gene serine (or cysteine) peptidase inhibitor, clade B, member 1a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Human Wrnip1 is localized in replication factories in a ubiquitin-binding zinc finger-dependent manner. Crosetto N, et al. J Biol Chem, 2008 Dec 12. PMID 18842586, Free PMC Article
    2. Analyses of the interaction of WRNIP1 with Werner syndrome protein (WRN) in vitro and in the cell. Kawabe Y, et al. DNA Repair (Amst), 2006 Jul 13. PMID 16769258
    3. A novel protein interacts with the Werner's syndrome gene product physically and functionally. Kawabe Yi, et al. J Biol Chem, 2001 Jun 8. PMID 11301316
    4. RNF166 plays a dual role for Lys63-linked ubiquitination and sumoylation of its target proteins. Hwang IY, et al. J Neural Transm (Vienna), 2022 Jun. PMID 34837535
    5. Comparison of human chromosome 6p25 with mouse chromosome 13 reveals a greatly expanded ov-serpin gene repertoire in the mouse. Kaiserman D, et al. Genomics, 2002 Mar. PMID 11863365

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables enzyme activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables single-stranded DNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA synthesis involved in DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA synthesis involved in DNA repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA-templated DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within immune system process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated DNA replication initiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    colocalizes_with chromosome, telomeric region ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ATPase WRNIP1
    Names
    Werner helicasae interacting protein 1
    Werner syndrome homolog interacting protein
    werner helicase-interacting protein 1
    NP_084491.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_030215.3 → NP_084491.3  ATPase WRNIP1

      See identical proteins and their annotated locations for NP_084491.3

      Status: VALIDATED

      Source sequence(s)
      AK041886, AK167570, AV237237
      Consensus CDS
      CCDS26427.1
      UniProtKB/Swiss-Prot
      Q3TCT7, Q6PDF0, Q8BUW5, Q8BWP6, Q8BY55, Q91XU0, Q921W3, Q9EQL3
      Related
      ENSMUSP00000021832.7, ENSMUST00000021832.7
      Conserved Domains (5) summary
      cd00009
      Location:235 → 371
      AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
      smart00734
      Location:17 → 40
      ZnF_Rad18; Rad18-like CCHC zinc finger
      PRK13342
      Location:221 → 656
      PRK13342; recombination factor protein RarA; Reviewed
      pfam12002
      Location:507 → 656
      MgsA_C; MgsA AAA+ ATPase C terminal
      pfam16193
      Location:417 → 506
      AAA_assoc_2; AAA C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      32986013..33006593
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91XU0.2 GenPept UniProtKB/Swiss-Prot:Q91XU0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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