Pla2g4e phospholipase A2, group IVE [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pla2g4eprovided by MGI
Official Full Name: phospholipase A2, group IVEprovided by MGI
Primary source: MGI:MGI:1919144
See related: Ensembl:ENSMUSG00000050211 AllianceGenome:MGI:1919144
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: C230096D22; Pla2epsilon; 2310026J01Rik
Summary: Enables several functions, including phosphatidylinositol phosphate binding activity; phosphatidylinositol-3,4-bisphosphate binding activity; and phospholipase A2 activity. Involved in N-acylphosphatidylethanolamine metabolic process and positive regulation of endocytic recycling. Located in early endosome membrane; lysosomal membrane; and plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human PLA2G4E (phospholipase A2 group IVE). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in CNS E18 (RPKM 3.5), cortex adult (RPKM 3.4) and 13 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 E5; 2 60.24 cM

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (119996893..120075816, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (120166412..120245630, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

murine cytosolic phospholipases A2 delta, epsilon, and zeta form a gene cluster with cPLA(2)beta
Title: Identification of novel cytosolic phospholipase A(2)s, murine cPLA(2){delta}, {epsilon}, and {zeta}, which form a gene cluster with cPLA(2){beta}.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)
Endonuclease-mediated (2) 1 citation

General gene information

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Markers

Pla2g4e (e-PCR), detects polymorphism
- UniSTS:546949

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables N-acyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables N-acyltransferase activity	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-dependent phospholipase A2 activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-dependent phospholipid binding	IBA Inferred from Biological aspect of Ancestor more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-3,4,5-trisphosphate binding	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylinositol-3,4-bisphosphate binding	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylinositol-3,5-bisphosphate binding	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylinositol-3-phosphate binding	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylinositol-4,5-bisphosphate binding	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylinositol-4-phosphate binding	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylinositol-5-phosphate binding	IDA Inferred from Direct Assay more info	PubMed
enables phospholipase A2 activity	IDA Inferred from Direct Assay more info	PubMed
enables phospholipase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in N-acylphosphatidylethanolamine metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in N-acylphosphatidylethanolamine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in glycerophospholipid catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within lipid catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in phospholipid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of endocytic recycling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of endocytic recycling	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in early endosome membrane	IDA Inferred from Direct Assay more info	PubMed
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in lysosomal membrane	IDA Inferred from Direct Assay more info	PubMed
located_in lysosome	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: cytosolic phospholipase A2 epsilon

Names: cPLA2-epsilon; calcium-dependent N-acyltransferase; phospholipase A2, group 4E

NP_001350019.1

EC 3.1.1.4

NP_001350020.1

EC 3.1.1.4

NP_001382399.1

EC 3.1.1.4

NP_808513.2

EC 3.1.1.4

XP_006499833.2

EC 3.1.1.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001363090.1 → NP_001350019.1 cytosolic phospholipase A2 epsilon isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) contains an alternate exon compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.

Source sequence(s)

AL833774, AL844608, BX000525

UniProtKB/TrEMBL

B2RQF4

Conserved Domains (2) summary

cl11396
Location:239 → 781

Patatin_and_cPLA2; Patatins and Phospholipases

cl14603
Location:1 → 101

C2; C2 domain
NM_001363091.1 → NP_001350020.1 cytosolic phospholipase A2 epsilon isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an alternate splice junction compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus compared to isoform 1.

Source sequence(s)

AL833774, AL844608, BC066085

Conserved Domains (1) summary

cl11396
Location:6 → 497

Patatin_and_cPLA2; Patatins and Phospholipases
NM_001395470.1 → NP_001382399.1 cytosolic phospholipase A2 epsilon isoform 4

Status: VALIDATED

Source sequence(s)

AL833774, AL844608, BX000525

UniProtKB/TrEMBL

B2RQF4

Conserved Domains (3) summary

cd07201
Location:284 → 826

cPLA2_Grp-IVB-IVD-IVE-IVF; Group IVB, IVD, IVE, and IVF cytosolic phospholipase A2; catalytic domain; Ca-dependent

cd04036
Location:38 → 146

C2_cPLA2; C2 domain present in cytosolic PhosphoLipase A2 (cPLA2)

pfam18695
Location:178 → 285

cPLA2_C2; Cytosolic phospholipases A2 C2-domain
NM_177845.4 → NP_808513.2 cytosolic phospholipase A2 epsilon isoform 1

See identical proteins and their annotated locations for NP_808513.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AB195277, AL833774, AL844608

Consensus CDS

CCDS16616.1

UniProtKB/Swiss-Prot

Q50L42, Q8BX44

UniProtKB/TrEMBL

B2RQF4

Related

ENSMUSP00000087525.5, ENSMUST00000090071.5

Conserved Domains (3) summary

cd07201
Location:328 → 870

cPLA2_Grp-IVB-IVD-IVE-IVF; Group IVB, IVD, IVE, and IVF cytosolic phospholipase A2; catalytic domain; Ca-dependent

cd04036
Location:82 → 190

C2_cPLA2; C2 domain present in cytosolic PhosphoLipase A2 (cPLA2)

smart00022
Location:324 → 811

PLAc; Cytoplasmic phospholipase A2, catalytic subunit

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

119996893..120075816 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006499770.5 → XP_006499833.2 cytosolic phospholipase A2 epsilon isoform X1

UniProtKB/TrEMBL

B2RQF4

Conserved Domains (3) summary

cd07201
Location:261 → 803

cPLA2_Grp-IVB-IVD-IVE-IVF; Group IVB, IVD, IVE, and IVF cytosolic phospholipase A2; catalytic domain; Ca-dependent

cd04036
Location:15 → 123

C2_cPLA2; C2 domain present in cytosolic PhosphoLipase A2 (cPLA2)

pfam18695
Location:155 → 262

cPLA2_C2; Cytosolic phospholipases A2 C2-domain