Odam odontogenic, ameloblast asssociated [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Odamprovided by MGI
Official Full Name: odontogenic, ameloblast asssociatedprovided by MGI
Primary source: MGI:MGI:1916842
See related: Ensembl:ENSMUSG00000009580 AllianceGenome:MGI:1916842
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: APIN; 2310011G06Rik
Summary: Involved in response to wounding. Located in cytoplasm; extracellular region; and nucleus. Orthologous to human ODAM (odontogenic, ameloblast associated). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward genital fat pad adult (RPKM 10.5) See more
Orthologs: human all
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Genomic context

Location:: 5 E1; 5 43.56 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (88032869..88042668)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (87885010..87894809)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ODAM promotes junctional epithelium-related gene expression via activation of WNT1 signaling pathway in an ameloblast-like cell line ALC.
Title: ODAM promotes junctional epithelium-related gene expression via activation of WNT1 signaling pathway in an ameloblast-like cell line ALC.
Data suggest that amelotin (AMTN), odontogenic ameloblast-associated protein (ODAM) and secretory calcium-binding phosphoprotein proline-glutamine rich 1 (SCPPPQ1) participate in structuring an extracellular matrix with the distinctive capacity of attaching epithelial cells to mineralized surfaces.
Title: Interactions of AMTN, ODAM and SCPPPQ1 proteins of a specialized basal lamina that attaches epithelial cells to tooth mineral.
We propose that ODAM has diverse functions that vary with protein location in various cell lines. Nuclear ODAM appears to be associated with MMP-20 regulation and tumorigenesis. Additional functions may take place in cytoplasm and extracellular matrix.
Title: Expression pattern, subcellular localization, and functional implications of ODAM in ameloblasts, odontoblasts, osteoblasts, and various cancer cells.
the BMP-2-BMPR-IB-ODAM-MAPK signaling cascade has important roles in ameloblast differentiation and enamel mineralization
Title: Odontogenic ameloblasts-associated protein (ODAM), via phosphorylation by bone morphogenetic protein receptor type IB (BMPR-IB), is implicated in ameloblast differentiation.
ODAM and AMTN are bona fide components of the basal lamina associated with maturation stage ameloblasts and they organize into different subdomains during the early maturation stage.
Title: Odontogenic ameloblast-associated and amelotin are novel basal lamina components.
Runx2 regulates the expression of ODAM and nuclear ODAM serves an important regulatory function in the mineralization of enamel through the regulation of MMP-20 apart from a different, currently unidentified, function of extracellular ODAM.
Title: The odontogenic ameloblast-associated protein (ODAM) cooperates with RUNX2 and modulates enamel mineralization via regulation of MMP-20.
The protein sequences deduced from the cloned cDNA for rat, mouse, pig, and human were aligned together with those obtained from four other mammal genomes. Apin is highly conserved in mammals.
Title: Characterization of Apin, a secreted protein highly expressed in tooth-associated epithelia.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within biomineral tissue development	IEA Inferred from Electronic Annotation more info
involved_in inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in odontogenesis of dentin-containing tooth	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of GTPase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in response to wounding	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cell periphery	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in mitotic spindle	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in supramolecular fiber	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: odontogenic ameloblast-associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_027128.3 → NP_081404.2 odontogenic ameloblast-associated protein precursor

See identical proteins and their annotated locations for NP_081404.2

Status: VALIDATED

Source sequence(s)

AC022298

Consensus CDS

CCDS19394.2

UniProtKB/Swiss-Prot

A1E960, Q9D7E6

Related

ENSMUSP00000117898.3, ENSMUST00000129757.9

Conserved Domains (1) summary

pfam15424
Location:16 → 273

ODAM; Odontogenic ameloblast-associated family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

88032869..88042668

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006535209.3 → XP_006535272.1 odontogenic ameloblast-associated protein isoform X1

Conserved Domains (1) summary

pfam15424
Location:16 → 286

ODAM; Odontogenic ameloblast-associated family