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    Ckmt1 creatine kinase, mitochondrial 1, ubiquitous [ Mus musculus (house mouse) ]

    Gene ID: 12716, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Ckmt1provided by MGI
    Official Full Name
    creatine kinase, mitochondrial 1, ubiquitousprovided by MGI
    Primary source
    MGI:MGI:99441
    See related
    Ensembl:ENSMUSG00000000308 AllianceGenome:MGI:99441
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mt-CK; mi-CK; U-MtCK; mia-CK; ScCKmit; UbCKmit
    Summary
    Predicted to enable creatine kinase activity and identical protein binding activity. Involved in negative regulation of apoptotic process and negative regulation of protein binding activity. Located in mitochondrion. Is expressed in several structures, including alimentary system; central nervous system; hemolymphoid system; sensory organ; and urinary system. Orthologous to several human genes including CKMT1A (creatine kinase, mitochondrial 1A). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in colon adult (RPKM 828.0), duodenum adult (RPKM 727.8) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    2 E5; 2 60.37 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (121188257..121194218)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (121357773..121363737)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene tubulin, gamma complex component 4 Neighboring gene transformation related protein 53 binding protein 1 Neighboring gene STARR-seq mESC enhancer starr_05522 Neighboring gene STARR-seq mESC enhancer starr_05523 Neighboring gene STARR-positive B cell enhancer ABC_E2640 Neighboring gene STARR-seq mESC enhancer starr_05524 Neighboring gene STARR-positive B cell enhancer ABC_E5972 Neighboring gene STARR-seq mESC enhancer starr_05525 Neighboring gene microtubule-associated protein 1 A Neighboring gene diphosphoinositol pentakisphosphate kinase 1 Neighboring gene STARR-positive B cell enhancer ABC_E640 Neighboring gene predicted gene, 33947 Neighboring gene stereocilin Neighboring gene cation channel, sperm associated 2 Neighboring gene STARR-positive B cell enhancer ABC_E9202 Neighboring gene STARR-positive B cell enhancer ABC_E3397 Neighboring gene protein disulfide isomerase associated 3 Neighboring gene elongation factor RNA polymerase II-like 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. In the absence of phosphate shuttling, exercise reveals the in vivo importance of creatine-independent mitochondrial ADP transport. Miotto PM, et al. Biochem J, 2016 Sep 15. PMID 27402793
    2. Mice lacking the UbCKmit isoform of creatine kinase reveal slower spatial learning acquisition, diminished exploration and habituation, and reduced acoustic startle reflex responses. Streijger F, et al. Mol Cell Biochem, 2004 Jan-Feb. PMID 14977190
    3. Mice deficient in ubiquitous mitochondrial creatine kinase are viable and fertile. Steeghs K, et al. Biochim Biophys Acta, 1995 Jun 30. PMID 7619831
    4. Mouse ubiquitous mitochondrial creatine kinase: gene organization and consequences from inactivation in mouse embryonic stem cells. Steeghs K, et al. DNA Cell Biol, 1995 Jun. PMID 7598809
    5. LncRNA n335586/miR-924/CKMT1A axis contributes to cell migration and invasion in hepatocellular carcinoma cells. Fan H, et al. Cancer Lett, 2018 Aug 10. PMID 29753758

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ckmt1 is Dispensable for Mitochondrial Bioenergetics Within White/Beige Adipose Tissue.
      Title: Ckmt1 is Dispensable for Mitochondrial Bioenergetics Within White/Beige Adipose Tissue.
    2. Mechanistic studies showed lncRNA n335586 promoted hepatocellular carcinoma (HCC) cells migration and invasion through facilitating the expression of its host gene mitochondrial creatine kinase (CKMT1A) by competitively binding miR-924.
      Title: LncRNA n335586/miR-924/CKMT1A axis contributes to cell migration and invasion in hepatocellular carcinoma cells.
    3. Hypothalamic plasticity of neuropeptide Y is lacking in brain-type creatine kinase double knockout mice with defective thermoregulation
      Title: Hypothalamic plasticity of neuropeptide Y is lacking in brain-type creatine kinase double knockout mice with defective thermoregulation.
    4. mitochondrial creatine kinase expression in hepatocellular carcinoma may be caused by hepatocarcinogenesis per se but not by loss of mitochondrial integrity, of which ASB9 could be a negative regulator
      Title: High ubiquitous mitochondrial creatine kinase expression in hepatocellular carcinoma denotes a poor prognosis with highly malignant potential.
    5. the knock-down of the mitochondrial creatine kinase-1 (CKMT1) by RNA interference causes the dissipation of the mitochondrial membrane potential
      Title: Reconstitution of CKMT1 expression fails to rescue cells from mitochondrial membrane potential dissipation: implications for controlling RNAi experiments.
    6. Mt-CK(-/-) on a C57BL/6 background do not develop LV hypertrophy or dysfunction even up to 1 year, and this may be explained by a compensatory increase in MM-CK activity and mitochondrial volume
      Title: Cardiac phenotype of mitochondrial creatine kinase knockout mice is modified on a pure C57BL/6 genetic background.
    7. Data suggest that amyloid precursor protein may regulate cellular energy levels and mitochondrial function via a direct interaction and stabilization of ubiquitous mitochondrial creatine kinase.
      Title: Stabilization of ubiquitous mitochondrial creatine kinase preprotein by APP family proteins.
    8. UbCKmit was expressed selectively in neurons and localized in their mitochondria in dendrites, cell bodies
      Title: Distinct cellular expressions of creatine synthetic enzyme GAMT and creatine kinases uCK-Mi and CK-B suggest a novel neuron-glial relationship for brain energy homeostasis.
    9. Brain type and mitochondrial ubiquitous CK double knockout mice have a reduced body weight, and demonstrate a severely impaired spatial learning in both a dry and a wet maze, lower nestbuilding activity and diminished acoustic startle reflex responses.
      Title: Structural and behavioural consequences of double deficiency for creatine kinases BCK and UbCKmit.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables creatine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables creatine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity, transferring phosphorus-containing groups IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phosphocreatine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner-outer membrane contact site ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in myelin sheath HDA PubMed 
    located_in perikaryon ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    creatine kinase U-type, mitochondrial
    Names
    acidic-type mitochondrial creatine kinase
    ubiquitous mitochondrial creatine kinase
    NP_001341998.1
    NP_001403881.1
    NP_001403882.1
    NP_001403883.1
    NP_001403884.1
    NP_001403885.1
    NP_001403886.1
    NP_034027.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355069.1 → NP_001341998.1  creatine kinase U-type, mitochondrial isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AL845466
      Consensus CDS
      CCDS16640.1
      UniProtKB/Swiss-Prot
      P30275
      UniProtKB/TrEMBL
      Q545N7
      Related
      ENSMUSP00000077349.3, ENSMUST00000078222.9
      Conserved Domains (1) summary
      cd00716
      Location:50 → 407
      creatine_kinase_like; Phosphagen (guanidino) kinases such as creatine kinase and similar enzymes

    2. NM_001416952.1 → NP_001403881.1  creatine kinase U-type, mitochondrial isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AL845466
      UniProtKB/Swiss-Prot
      P30275
      UniProtKB/TrEMBL
      Q545N7

    3. NM_001416953.1 → NP_001403882.1  creatine kinase U-type, mitochondrial isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL845466

    4. NM_001416954.1 → NP_001403883.1  creatine kinase U-type, mitochondrial isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL845466

    5. NM_001416955.1 → NP_001403884.1  creatine kinase U-type, mitochondrial isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL845466

    6. NM_001416956.1 → NP_001403885.1  creatine kinase U-type, mitochondrial isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL845466

    7. NM_001416957.1 → NP_001403886.1  creatine kinase U-type, mitochondrial isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL845466

    8. NM_009897.4 → NP_034027.1  creatine kinase U-type, mitochondrial isoform 1 precursor

      See identical proteins and their annotated locations for NP_034027.1

      Status: VALIDATED

      Source sequence(s)
      AL845466
      Consensus CDS
      CCDS16640.1
      UniProtKB/Swiss-Prot
      P30275
      UniProtKB/TrEMBL
      Q545N7
      Related
      ENSMUSP00000000317.6, ENSMUST00000000317.13
      Conserved Domains (1) summary
      cd00716
      Location:50 → 407
      creatine_kinase_like; Phosphagen (guanidino) kinases such as creatine kinase and similar enzymes

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      121188257..121194218
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P30275.1 GenPept UniProtKB/Swiss-Prot:P30275

    Gene LinkOut

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