U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Arl15 ADP-ribosylation factor-like 15 [ Mus musculus (house mouse) ]

    Gene ID: 218639, updated on 5-Mar-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Arl15provided by MGI
    Official Full Name
    ADP-ribosylation factor-like 15provided by MGI
    Primary source
    MGI:MGI:2442308
    See related
    Ensembl:ENSMUSG00000042348 AllianceGenome:MGI:2442308
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Arfrp2; A430036I03; C230032K13Rik
    Summary
    Predicted to enable GTP binding activity. Is expressed in genitourinary system; gut gland; heart; nervous system; and stomach. Orthologous to human ARL15 (ADP ribosylation factor like GTPase 15). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E14 (RPKM 3.6), CNS E18 (RPKM 3.3) and 28 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Arl15 in Genome Data Viewer
    Location:
    13 D2.2; 13 64.02 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (113929963..114293998)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (113794506..114157462)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31276 Neighboring gene STARR-positive B cell enhancer ABC_E933 Neighboring gene GC-rich promoter binding protein 1-like 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_35739 Neighboring gene STARR-positive B cell enhancer ABC_E7291 Neighboring gene STARR-seq mESC enhancer starr_35743 Neighboring gene STARR-seq mESC enhancer starr_35745 Neighboring gene RIKEN cDNA A430090L17 gene Neighboring gene STARR-seq mESC enhancer starr_35752 Neighboring gene predicted gene, 41072 Neighboring gene STARR-seq mESC enhancer starr_35753 Neighboring gene STARR-seq mESC enhancer starr_35756 Neighboring gene STARR-seq mESC enhancer starr_35758 Neighboring gene NADH:ubiquinone oxidoreductase core subunit S4 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:115178183-115178393

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The metabolic syndrome- associated small G protein ARL15 plays a role in adipocyte differentiation and adiponectin secretion. Rocha N, et al. Sci Rep, 2017 Dec 14. PMID 29242557, Free PMC Article
    2. ADP-ribosylation factor-like GTPase 15 enhances insulin-induced AKT phosphorylation in the IR/IRS1/AKT pathway by interacting with ASAP2 and regulating PDPK1 activity. Zhao J, et al. Biochem Biophys Res Commun, 2017 May 13. PMID 28322786
    3. Gene-trap mutagenesis using Mol/MSM-1 embryonic stem cells from MSM/Ms mice. Nakahara M, et al. Mamm Genome, 2013 Jun. PMID 23604909
    4. Tagging genes with cassette-exchange sites. Cobellis G, et al. Nucleic Acids Res, 2005 Mar 1. PMID 15741177, Free PMC Article
    5. Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette. Taniwaki T, et al. Dev Growth Differ, 2005 Apr. PMID 15840001

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cleft palate and minor metabolic disturbances in a mouse global Arl15 gene knockout.
      Title: Cleft palate and minor metabolic disturbances in a mouse global Arl15 gene knockout.
    2. ARL15 plays a role in adipocyte differentiation and adiponectin secretion
      Title: The metabolic syndrome- associated small G protein ARL15 plays a role in adipocyte differentiation and adiponectin secretion.
    3. In conclusion, we have identified that ARL15 acts as an insulin-sensitizing effector molecule to upregulate the phosphorylation of members of the canonical IR/IRS1/PDPK1/AKT insulin pathway by interacting with its GAP ASAP2 and activating PDPK1. This research may provide new insights into GTPase-mediated insulin signalling regulation and facilitate the development of new pharmacotherapeutic targets for insulin sensitizati
      Title: ADP-ribosylation factor-like GTPase 15 enhances insulin-induced AKT phosphorylation in the IR/IRS1/AKT pathway by interacting with ASAP2 and regulating PDPK1 activity.
    Submit: New GeneRIF Correction

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3) 
    • Endonuclease-mediated (2) 

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    ADP-ribosylation factor-like protein 15
    Names
    ADP-ribosylation factor related protein 2
    ARF-related protein 2

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172595.5 → NP_766183.1  ADP-ribosylation factor-like protein 15

      See identical proteins and their annotated locations for NP_766183.1

      Status: VALIDATED

      Source sequence(s)
      AC126939, AC154862
      Consensus CDS
      CCDS36785.1
      UniProtKB/Swiss-Prot
      Q8BGR6
      Related
      ENSMUSP00000088740.7, ENSMUST00000091201.7
      Conserved Domains (2) summary
      COG1100
      Location:31 → 197
      Gem1; GTPase SAR1 family domain [General function prediction only]
      cl21455
      Location:34 → 193
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      113929963..114293998
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006517630.4 → XP_006517693.1  ADP-ribosylation factor-like protein 15 isoform X4

      See identical proteins and their annotated locations for XP_006517693.1

      UniProtKB/TrEMBL
      B7ZN40
      Related
      ENSMUSP00000153127.2, ENSMUST00000224068.2
      Conserved Domains (1) summary
      cl38936
      Location:34 → 173
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. XM_006517629.5 → XP_006517692.1  ADP-ribosylation factor-like protein 15 isoform X3

      Conserved Domains (1) summary
      cl38936
      Location:34 → 165
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    3. XM_030247239.2 → XP_030103099.1  ADP-ribosylation factor-like protein 15 isoform X1

      Conserved Domains (1) summary
      cl38936
      Location:34 → 193
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    4. XM_011244655.4 → XP_011242957.1  ADP-ribosylation factor-like protein 15 isoform X2

      Conserved Domains (1) summary
      cl38936
      Location:26 → 185
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BGR6.1 GenPept UniProtKB/Swiss-Prot:Q8BGR6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous