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    Capn3 calpain 3 [ Mus musculus (house mouse) ]

    Gene ID: 12335, updated on 7-Sep-2021

    Summary

    Official Symbol
    Capn3provided by MGI
    Official Full Name
    calpain 3provided by MGI
    Primary source
    MGI:MGI:107437
    See related
    Ensembl:ENSMUSG00000079110
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ca; Lp; p9; Cap; p94; Lp82; Capa3; Capa-3; AI323605
    Expression
    Biased expression in thymus adult (RPKM 10.1), genital fat pad adult (RPKM 5.2) and 12 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Capn3 in Genome Data Viewer
    Location:
    2 E5; 2 60.31 cM
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (120294074..120335400)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (120463593..120504919)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (120289329..120330655)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene VPS39 HOPS complex subunit Neighboring gene transmembrane protein 87A Neighboring gene glucosidase, alpha; neutral C Neighboring gene RIKEN cDNA 4931402G19 gene Neighboring gene zinc finger protein 106 Neighboring gene synaptosomal-associated protein 23

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Potential readthrough

    Included gene: Ganc

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables calcium-dependent cysteine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables calcium-dependent cysteine-type endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables calcium-dependent cysteine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables catalytic activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ligase regulator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables molecular adaptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables peptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables sodium ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables structural constituent of muscle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables titin binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in G1 to G0 transition involved in cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in calcium-dependent self proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to calcium ion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to salt stress IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in muscle structure development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within myofibril assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein sumoylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of skeletal muscle cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of NF-kappaB transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of proteolysis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of release of sequestered calcium ion into cytosol IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of satellite cell activation involved in skeletal muscle regeneration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in programmed cell death IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein destabilization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein-containing complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within proteolysis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in proteolysis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of I-kappaB kinase/NF-kappaB signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of I-kappaB kinase/NF-kappaB signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of catalytic activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of myoblast differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to calcium ion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to muscle activity ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within sarcomere organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in self proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sodium-dependent self proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in T-tubule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in Z disc ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in myofibril ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    calpain-3
    Names
    CANP 3
    calcium-activated neutral proteinase 3
    calpain L3
    calpain p94
    muscle-specific calcium-activated neutral protease 3
    skeletal muscle specific calpain p94
    NP_001103231.1
    NP_001171270.1
    NP_031627.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109761.2NP_001103231.1  calpain-3 isoform b

      See identical proteins and their annotated locations for NP_001103231.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (b) has multiple differences, compared to variant a. The resulting protein (isoform b) is shorter and has a distinct N-terminus when it is compared to isoform a.
      Source sequence(s)
      BB202194, BC090661
      Consensus CDS
      CCDS50680.1
      UniProtKB/TrEMBL
      Q0VGP9
      Related
      ENSMUSP00000028748.7, ENSMUST00000028748.14
      Conserved Domains (5) summary
      cd00051
      Location:585639
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00648
      Location:51347
      Peptidase_C2; Calpain family cysteine protease
      pfam01067
      Location:361511
      Calpain_III; Calpain large subunit, domain III
      pfam13499
      Location:616672
      EF-hand_7; EF-hand domain pair
      cl08302
      Location:616705
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    2. NM_001177799.1NP_001171270.1  calpain-3 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (c) lacks several alternate, in-frame coding exons, compared to variant a. The resulting protein (isoform c) is shorter when it is compared to isoform a.
      Source sequence(s)
      AF127766, BB202194, BC090661, BC139790, BY142198, CN664345
      Consensus CDS
      CCDS50679.1
      UniProtKB/Swiss-Prot
      Q64691
      UniProtKB/TrEMBL
      A4QPE6, Q0VGP9
      Related
      ENSMUSP00000106349.2, ENSMUST00000110721.9
      Conserved Domains (5) summary
      cd00051
      Location:605659
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00648
      Location:77367
      Peptidase_C2; Calpain family cysteine protease
      pfam01067
      Location:381531
      Calpain_III; Calpain large subunit, domain III
      pfam13499
      Location:636692
      EF-hand_7; EF-hand domain pair
      cl08302
      Location:636725
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    3. NM_007601.3NP_031627.2  calpain-3 isoform a

      See identical proteins and their annotated locations for NP_031627.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (a) is the longest transcript and it encodes the longest protein (isoform a).
      Source sequence(s)
      AL935121, BB202194, BC090661, BC139790, BY142198, CN664345
      Consensus CDS
      CCDS16620.1
      UniProtKB/Swiss-Prot
      Q64691
      UniProtKB/TrEMBL
      A4QPE6, Q0VGP9
      Related
      ENSMUSP00000028749.8, ENSMUST00000028749.15
      Conserved Domains (6) summary
      cd00051
      Location:697751
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00648
      Location:77415
      Peptidase_C2; Calpain family cysteine protease
      pfam01067
      Location:429579
      Calpain_III; Calpain large subunit, domain III
      pfam13499
      Location:728784
      EF-hand_7; EF-hand domain pair
      pfam16648
      Location:583653
      Calpain_u2; Unstructured region on Calpain-3
      cl08302
      Location:728817
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      120294074..120335400
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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