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    Tiprl TIP41, TOR signalling pathway regulator-like (S. cerevisiae) [ Mus musculus (house mouse) ]

    Gene ID: 226591, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Tiprlprovided by MGI
    Official Full Name
    TIP41, TOR signalling pathway regulator-like (S. cerevisiae)provided by MGI
    Primary source
    MGI:MGI:1915087
    See related
    Ensembl:ENSMUSG00000040843 AllianceGenome:MGI:1915087
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1810011K17Rik
    Summary
    Predicted to be involved in DNA damage checkpoint signaling; TOR signaling; and negative regulation of phosphoprotein phosphatase activity. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Is expressed in several structures, including brain; cardiovascular system; genitourinary system; gut; and immune system. Orthologous to human TIPRL (TOR signaling pathway regulator). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 10.8), CNS E14 (RPKM 8.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    1 H2.2; 1 72.55 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (165039855..165110228, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (165212286..165282659, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene T-box 19 Neighboring gene STARR-seq mESC enhancer starr_02894 Neighboring gene SFT2 domain containing 2 Neighboring gene STARR-seq mESC enhancer starr_02896 Neighboring gene STARR-seq mESC enhancer starr_02898 Neighboring gene G protein-coupled receptor 161 Neighboring gene DDB1 and CUL4 associated factor 6 Neighboring gene STARR-seq mESC enhancer starr_02900 Neighboring gene STARR-positive B cell enhancer ABC_E2016 Neighboring gene STARR-positive B cell enhancer ABC_E119 Neighboring gene predicted gene, 24637 Neighboring gene mitochondrial pyruvate carrier 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Methylation-regulated decommissioning of multimeric PP2A complexes. Wu CG, et al. Nat Commun, 2017 Dec 22. PMID 29273778, Free PMC Article
    2. TIPRL Inhibits Protein Phosphatase 4 Activity and Promotes H2AX Phosphorylation in the DNA Damage Response. Rosales KR, et al. PLoS One, 2015. PMID 26717153, Free PMC Article
    3. New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules. Das R, et al. J Cell Sci, 2019 Jun 17. PMID 31138677, Free PMC Article
    4. Complementary proteomics strategies capture an ataxin-1 interactome in Neuro-2a cells. Zhang S, et al. Sci Data, 2018 Nov 20. PMID 30457570, Free PMC Article
    5. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in TOR signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of phosphoprotein phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of phosphoprotein phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    TIP41-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357410.1 → NP_001344339.1  TIP41-like protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC154142
      Conserved Domains (1) summary
      pfam04176
      Location:38 → 206
      TIP41; TIP41-like family

    2. NM_001357411.1 → NP_001344340.1  TIP41-like protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC154142
      Conserved Domains (1) summary
      pfam04176
      Location:9 → 177
      TIP41; TIP41-like family

    3. NM_145513.4 → NP_663488.1  TIP41-like protein isoform 1

      See identical proteins and their annotated locations for NP_663488.1

      Status: VALIDATED

      Source sequence(s)
      AK049784, CF531065
      Consensus CDS
      CCDS15441.1
      UniProtKB/Swiss-Prot
      Q8BH58
      Related
      ENSMUSP00000037514.6, ENSMUST00000043235.8
      Conserved Domains (1) summary
      pfam04176
      Location:50 → 218
      TIP41; TIP41-like family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      165039855..165110228 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011238792.3 → XP_011237094.1  TIP41-like protein isoform X1

      See identical proteins and their annotated locations for XP_011237094.1

      Conserved Domains (1) summary
      pfam04176
      Location:9 → 177
      TIP41; TIP41-like family

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_180963.1: Suppressed sequence

      Description
      NM_180963.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BH58.1 GenPept UniProtKB/Swiss-Prot:Q8BH58

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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