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    Ntaq1 N-terminal glutamine amidase 1 [ Mus musculus (house mouse) ]

    Gene ID: 76773, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Ntaq1provided by MGI
    Official Full Name
    N-terminal glutamine amidase 1provided by MGI
    Primary source
    MGI:MGI:1924023
    See related
    Ensembl:ENSMUSG00000022359 AllianceGenome:MGI:1924023
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Wdyhv1; 2410187C16Rik
    Summary
    Enables protein-N-terminal glutamine amidohydrolase activity. Involved in cellular protein modification process. Located in cytosol and nucleus. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and immune system. Orthologous to human NTAQ1 (N-terminal glutamine amidase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in thymus adult (RPKM 6.7), limb E14.5 (RPKM 6.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ntaq1 in Genome Data Viewer
    Location:
    15 D1; 15 24.38 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (58004730..58022050)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (58141335..58158654)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene zinc fingers and homeoboxes 1 Neighboring gene STARR-positive B cell enhancer ABC_E941 Neighboring gene ATPase family, AAA domain containing 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:57966689-57966916 Neighboring gene small nuclear ribonucleoprotein Sm D2-like Neighboring gene STARR-positive B cell enhancer ABC_E3140 Neighboring gene predicted gene, 23475 Neighboring gene predicted gene, 22488 Neighboring gene STARR-seq mESC enhancer starr_38749 Neighboring gene predicted gene, 36112 Neighboring gene F-box protein 32 Neighboring gene predicted gene, 36193

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The auto-generated fragment of the Usp1 deubiquitylase is a physiological substrate of the N-end rule pathway. Piatkov KI, et al. Mol Cell, 2012 Dec 28. PMID 23159736, Free PMC Article
    2. Glutamine-specific N-terminal amidase, a component of the N-end rule pathway. Wang H, et al. Mol Cell, 2009 Jun 26. PMID 19560421, Free PMC Article
    3. Identification of an Alternative Splicing Product of the Otx2 Gene Expressed in the Neural Retina and Retinal Pigmented Epithelial Cells. Kole C, et al. PLoS One, 2016. PMID 26985665, Free PMC Article
    4. Spatiotemporal regulation of GLI target genes in the mammalian limb bud. Lewandowski JP, et al. Dev Biol, 2015 Oct 1. PMID 26238476, Free PMC Article
    5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-N-terminal asparagine amidohydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-N-terminal glutamine amidohydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-N-terminal glutamine amidohydrolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein catabolic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in protein modification process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein N-terminal glutamine amidohydrolase
    Names
    N-terminal Gln amidase
    WDYHV motif containing 1
    WDYHV motif-containing protein 1
    nt(Q)-amidase
    protein NH2-terminal glutamine deamidase
    NP_001313528.1
    NP_001313531.1
    NP_084010.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001326599.1 → NP_001313528.1  protein N-terminal glutamine amidohydrolase isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate 3' terminal exon, resulting in a novel 3' coding region and stop codon, compared to variant 1. It encodes isoform 2, which contains a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC113292, AK010831, FO710768
      Consensus CDS
      CCDS88766.1
      UniProtKB/TrEMBL
      Q9CWD7
      Related
      ENSMUSP00000154671.2, ENSMUST00000227142.2
      Conserved Domains (1) summary
      pfam09764
      Location:25 → 171
      Nt_Gln_amidase; N-terminal glutamine amidase

    2. NM_001326602.1 → NP_001313531.1  protein N-terminal glutamine amidohydrolase isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate splice site and lacks two alternate exons in the 3' region, resulting in a frameshift compared to variant 1. It encodes isoform 3, which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AI843652, AK167510, FO710768
      Consensus CDS
      CCDS88767.1
      UniProtKB/TrEMBL
      A0A2I3BQY8
      Related
      ENSMUSP00000154254.2, ENSMUST00000226955.2

    3. NM_029734.2 → NP_084010.1  protein N-terminal glutamine amidohydrolase isoform 1

      See identical proteins and their annotated locations for NP_084010.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
      Source sequence(s)
      AI843652, AK150578, FO710768
      Consensus CDS
      CCDS27490.1
      UniProtKB/Swiss-Prot
      Q80WB5
      Related
      ENSMUSP00000064622.8, ENSMUST00000067563.9
      Conserved Domains (1) summary
      pfam09764
      Location:25 → 194
      Nt_Gln_amidase; N-terminal glutamine amidase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      58004730..58022050
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_001781578.2 RNA Sequence

    2. XR_003951445.2 RNA Sequence

    3. XR_001781577.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80WB5.1 GenPept UniProtKB/Swiss-Prot:Q80WB5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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