Trps1 transcriptional repressor GATA binding 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Trps1provided by MGI
Official Full Name: transcriptional repressor GATA binding 1provided by MGI
Primary source: MGI:MGI:1927616
See related: Ensembl:ENSMUSG00000038679 AllianceGenome:MGI:1927616
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: D15Ertd586e
Summary: Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and protein domain specific binding activity. Involved in hair follicle development and regulation of chondrocyte differentiation. Acts upstream of or within several processes, including chondrocyte differentiation; negative regulation of transcription, DNA-templated; and positive regulation of extrinsic apoptotic signaling pathway via death domain receptors. Located in nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; limb; and skin. Used to study trichorhinophalangeal syndrome type I. Human ortholog(s) of this gene implicated in osteochondrodysplasia; trichorhinophalangeal syndrome type I; and trichorhinophalangeal syndrome type III. Orthologous to human TRPS1 (transcriptional repressor GATA binding 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in limb E14.5 (RPKM 5.4), bladder adult (RPKM 4.0) and 17 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 C; 15 19.18 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (50518149..50754027, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (50654757..50890631, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cis-regulatory control of mammalian Trps1 gene expression.
Title: Cis-regulatory control of mammalian Trps1 gene expression.
Trps1 acts as a regulator of Sf-1 transcription and testosterone synthesis in mouse Leydig cells.
Title: Trps1 acts as a regulator of Sf-1 transcription and testosterone synthesis in mouse Leydig cells.
Trps1 transcription factor represses phosphate-induced expression of SerpinB2 in osteogenic cells.
Title: Trps1 transcription factor represses phosphate-induced expression of SerpinB2 in osteogenic cells.
Study characterized the murine Wnt5a promoter and showed that two alternative Wnt5a transcripts, Ts1 and Ts2, are differentially expressed in the developing skeletal elements. Ts2 expression decreases while Ts1 expression increases during chondrocyte differentiation. The transcription factor Trps1 and the activator form of Gli3 (Gli3A), which is a mediator of Hedgehog signaling, activate Wnt5a expression.
Title: Wnt5a is a transcriptional target of Gli3 and Trps1 at the onset of chondrocyte hypertrophy.
These results demonstrated that TRPS1 plays indispensable roles during mouse zygotic genome activation through controlling the expression of zygotic genome activation markers MuERV-L and Zscan4d, transcription factors SOX2 and OCT4, and key histone markers H3K4me3 and H3K27me3.
Title: Atypical GATA protein TRPS1 plays indispensable roles in mouse two-cell embryo.
TRPS1 can function as a context-dependent tumor suppressor in breast cancer, while being essential for growth and differentiation of normal mammary epithelial cells.
Title: TRPS1 acts as a context-dependent regulator of mammary epithelial cell growth/differentiation and breast cancer development.
This study has demonstrated that Trps1 is a positive regulator of cell proliferation in both dental mesenchyme and epithelium, suggesting that the microdontia in trichorhinophalangeal syndrome is likely due to decreased cell proliferation in developing tooth organs.
Title: Trps1 transcription factor regulates mineralization of dental tissues and proliferation of tooth organ cells.
our findings partially explain why patients with TRPS show a broad range of congenital cardiac defects, although Trps1 expression is observed in a more restricted fashion.
Title: Fate mapping of Trps1 daughter cells during cardiac development using novel Trps1-Cre mice.
Taken together, these results show that hair follicle development in Trps1 KO embryos is impaired directly or indirectly by decreased Noggin expression.
Title: Trps1 deficiency inhibits the morphogenesis of secondary hair follicles via decreased Noggin expression.
association between SNP within TRPS1 and BMD
Title: Trps1 differentially modulates the bone mineral density between male and female mice and its polymorphism associates with BMD differently between women and men.

Submit: New GeneRIF Correction See all GeneRIFs (32)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Chemically induced (ENU) (1)
Endonuclease-mediated (6)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D15Ertd586e (e-PCR), detects polymorphism
- UniSTS:167170

PMC139891P1 (e-PCR)
- UniSTS:270903

Trps1 (e-PCR), detects polymorphism
- UniSTS:546470

Trps1 (e-PCR), detects polymorphism
- UniSTS:546471

RH135865 (e-PCR)
- UniSTS:209863

AI447310 (e-PCR)
- UniSTS:164577

NoName (e-PCR)
- UniSTS:237295

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell surface receptor protein serine/threonine kinase signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within chondrocyte differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in hair follicle development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of DNA-templated transcription	IPI Inferred from Physical Interaction more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of extrinsic apoptotic signaling pathway via death domain receptors	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of chondrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in skeletal system development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of chromatin	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: zinc finger transcription factor Trps1

Names: trichorhinophalangeal syndrome I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001310481.1 → NP_001297410.1 zinc finger transcription factor Trps1 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AC155307, AK142355, CN667090, DV651380

Consensus CDS

CCDS79370.1

UniProtKB/TrEMBL

Q499D6, V9GX74

Related

ENSMUSP00000139017.2, ENSMUST00000183757.8

Conserved Domains (2) summary

smart00401
Location:895 → 938

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]

cd00202
Location:899 → 955

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
NM_001310485.1 → NP_001297414.1 zinc finger transcription factor Trps1 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) is alternatively spliced in the 5' region and contains an additional in-frame exon compared to variant 1. The resulting isoform (3) is shorter than isoform 1.

Source sequence(s)

AC155307, AK142355, CN667090, DV651380

Consensus CDS

CCDS79371.1

UniProtKB/TrEMBL

Q80V18, V9GXE9

Related

ENSMUSP00000139115.2, ENSMUST00000183997.8

Conserved Domains (2) summary

smart00401
Location:706 → 749

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]

cd00202
Location:710 → 766

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
NM_032000.2 → NP_114389.2 zinc finger transcription factor Trps1 isoform 2

See identical proteins and their annotated locations for NP_114389.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) is alternatively spliced at the 5' end and uses an in-frame, downstream start codon compared to variant 1. The resulting isoform (2) has a shorter N-terminus compared to isoform 1.

Source sequence(s)

AC142245, AC155307, DV651380

Consensus CDS

CCDS27460.1

UniProtKB/TrEMBL

G3UW90, Q499D6

Related

ENSMUSP00000129779.2, ENSMUST00000165201.9

Conserved Domains (1) summary

cd00202
Location:895 → 951

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

50518149..50754027 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036159653.1 → XP_036015546.1 zinc finger transcription factor Trps1 isoform X6

UniProtKB/TrEMBL

Q80V18

Related

ENSMUSP00000138905.2, ENSMUST00000184885.8

Conserved Domains (1) summary

cd00202
Location:695 → 751

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
XM_011245780.4 → XP_011244082.1 zinc finger transcription factor Trps1 isoform X2

See identical proteins and their annotated locations for XP_011244082.1

UniProtKB/TrEMBL

Q499D6

Conserved Domains (1) summary

cd00202
Location:906 → 962

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
XM_036159648.1 → XP_036015541.1 zinc finger transcription factor Trps1 isoform X2

UniProtKB/TrEMBL

Q499D6

Conserved Domains (1) summary

cd00202
Location:906 → 962

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
XM_036159651.1 → XP_036015544.1 zinc finger transcription factor Trps1 isoform X4

UniProtKB/TrEMBL

Q80V18, Q8K1J0

Conserved Domains (1) summary

cd00202
Location:706 → 762

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
XM_036159652.1 → XP_036015545.1 zinc finger transcription factor Trps1 isoform X6

UniProtKB/TrEMBL

Q80V18

Conserved Domains (1) summary

cd00202
Location:695 → 751

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
XM_030248828.2 → XP_030104688.1 zinc finger transcription factor Trps1 isoform X4

UniProtKB/TrEMBL

Q80V18, Q8K1J0

Conserved Domains (1) summary

cd00202
Location:706 → 762

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
XM_011245776.4 → XP_011244078.1 zinc finger transcription factor Trps1 isoform X2

See identical proteins and their annotated locations for XP_011244078.1

UniProtKB/TrEMBL

Q499D6

Conserved Domains (1) summary

cd00202
Location:906 → 962

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
XM_036159650.1 → XP_036015543.1 zinc finger transcription factor Trps1 isoform X4

UniProtKB/TrEMBL

Q80V18, Q8K1J0

Conserved Domains (1) summary

cd00202
Location:706 → 762

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
XM_036159649.1 → XP_036015542.1 zinc finger transcription factor Trps1 isoform X3

UniProtKB/TrEMBL

G3UW90, Q499D6

Conserved Domains (1) summary

cd00202
Location:895 → 951

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
XM_011245778.4 → XP_011244080.1 zinc finger transcription factor Trps1 isoform X2

See identical proteins and their annotated locations for XP_011244080.1

UniProtKB/TrEMBL

Q499D6

Conserved Domains (1) summary

cd00202
Location:906 → 962

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
XM_006521560.4 → XP_006521623.1 zinc finger transcription factor Trps1 isoform X1

UniProtKB/TrEMBL

Q499D6

Conserved Domains (1) summary

cd00202
Location:910 → 966

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
XM_030248826.2 → XP_030104686.1 zinc finger transcription factor Trps1 isoform X2

UniProtKB/TrEMBL

Q499D6

Conserved Domains (1) summary

cd00202
Location:906 → 962

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
XM_006521563.4 → XP_006521626.1 zinc finger transcription factor Trps1 isoform X5

UniProtKB/TrEMBL

Q80V18

Conserved Domains (1) summary

cd00202
Location:699 → 755

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
XM_036159645.1 → XP_036015538.1 zinc finger transcription factor Trps1 isoform X2

UniProtKB/TrEMBL

Q499D6

Conserved Domains (1) summary

cd00202
Location:906 → 962

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
XM_011245777.3 → XP_011244079.1 zinc finger transcription factor Trps1 isoform X2

See identical proteins and their annotated locations for XP_011244079.1

UniProtKB/TrEMBL

Q499D6

Conserved Domains (1) summary

cd00202
Location:906 → 962

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
XM_036159647.1 → XP_036015540.1 zinc finger transcription factor Trps1 isoform X2

UniProtKB/TrEMBL

Q499D6

Conserved Domains (1) summary

cd00202
Location:906 → 962

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
XM_036159646.1 → XP_036015539.1 zinc finger transcription factor Trps1 isoform X2

UniProtKB/TrEMBL

Q499D6

Conserved Domains (1) summary

cd00202
Location:906 → 962

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C