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    Fez2 fasciculation and elongation protein zeta 2 [ Mus musculus (house mouse) ]

    Gene ID: 225020, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Fez2provided by MGI
    Official Full Name
    fasciculation and elongation protein zeta 2provided by MGI
    Primary source
    MGI:MGI:2675856
    See related
    Ensembl:ENSMUSG00000056121 AllianceGenome:MGI:2675856
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    9030616F16; D17Ertd315e
    Summary
    Predicted to be involved in negative regulation of autophagosome assembly. Predicted to be active in axon and cytoplasm. Is expressed in embryo. Orthologous to human FEZ2 (fasciculation and elongation protein zeta 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in bladder adult (RPKM 18.4), cerebellum adult (RPKM 9.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    17 E2- E3; 17 48.57 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (78676641..78725581, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (78369212..78418152, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene cysteine rich transmembrane BMP regulator 1 Neighboring gene predicted gene, 41620 Neighboring gene predicted gene, 52306 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:78761825-78761978 Neighboring gene STARR-seq mESC enhancer starr_43268 Neighboring gene predicted gene, 32336 Neighboring gene predicted gene, 53960 Neighboring gene predicted gene, 32464 Neighboring gene 60S ribosomal protein L39 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of a tissue-non-specific homologue of axonal fasciculation and elongation protein zeta-1. Fujita T, et al. Biochem Biophys Res Commun, 2004 Jan 16. PMID 14697253
    2. Essential role for the Prader-Willi syndrome protein necdin in axonal outgrowth. Lee S, et al. Hum Mol Genet, 2005 Mar 1. PMID 15649943
    3. The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase. Groh BS, et al. EMBO Rep, 2016 May. PMID 27113764, Free PMC Article
    4. Matrix-screening reveals a vast potential for direct protein-protein interactions among RNA binding proteins. Lang B, et al. Nucleic Acids Res, 2021 Jul 9. PMID 34133714, Free PMC Article
    5. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FEZ2 plays an important role in the morphological changes of various cells by associating with PKCzeta in a tissue-non-specific manner
      Title: Identification of a tissue-non-specific homologue of axonal fasciculation and elongation protein zeta-1.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of autophagosome assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    fasciculation and elongation protein zeta-2
    Names
    zygin 2
    zygin II

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001285940.1 → NP_001272869.1  fasciculation and elongation protein zeta-2 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC103598, AC151270
      Consensus CDS
      CCDS70844.1
      UniProtKB/TrEMBL
      D3Z6D5, Q6P395
      Related
      ENSMUSP00000108106.2, ENSMUST00000112487.3
      Conserved Domains (1) summary
      pfam07763
      Location:42 → 265
      FEZ; FEZ-like protein

    2. NM_001285946.1 → NP_001272875.1  fasciculation and elongation protein zeta-2 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR and has multiple coding region differences, compared to variant 1, one of which results in a frameshift. The resulting protein (isoform 3) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC103598, AC151270
      Consensus CDS
      CCDS89154.1
      UniProtKB/TrEMBL
      A0A3Q4EGS7, Q6P395
      Related
      ENSMUSP00000157359.2, ENSMUST00000234029.2
      Conserved Domains (1) summary
      pfam07763
      Location:42 → 265
      FEZ; FEZ-like protein

    3. NM_001285949.1 → NP_001272878.1  fasciculation and elongation protein zeta-2 isoform 4

      See identical proteins and their annotated locations for NP_001272878.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 3' UTR and has multiple coding region differences including the use of an alternate 3' terminal exon. The resulting protein (isoform 4) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC103598, AC151270
      Consensus CDS
      CCDS89155.1
      UniProtKB/TrEMBL
      Q3TN06, Q6P395
      Related
      ENSMUSP00000157187.2, ENSMUST00000234052.2
      Conserved Domains (1) summary
      pfam07763
      Location:42 → 265
      FEZ; FEZ-like protein

    4. NM_001360407.1 → NP_001347336.1  fasciculation and elongation protein zeta-2 isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 3' UTR and has multiple coding region differences, compared to variant 1. The resulting protein (isoform 5) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC103598, AC151270
      Consensus CDS
      CCDS89156.1
      UniProtKB/TrEMBL
      A0A3Q4EH67, Q6P395
      Related
      ENSMUSP00000157338.2, ENSMUST00000234530.2
      Conserved Domains (1) summary
      pfam07763
      Location:42 → 265
      FEZ; FEZ-like protein

    5. NM_199448.3 → NP_955519.1  fasciculation and elongation protein zeta-2 isoform 2

      See identical proteins and their annotated locations for NP_955519.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the central coding region compared to vatiant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC103598, AC151270, AK150241
      Consensus CDS
      CCDS28977.1
      UniProtKB/Swiss-Prot
      Q6TYB5
      UniProtKB/TrEMBL
      Q3U049, Q6P395
      Related
      ENSMUSP00000068987.8, ENSMUST00000070039.14
      Conserved Domains (1) summary
      pfam07763
      Location:42 → 265
      FEZ; FEZ-like protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      78676641..78725581 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6TYB5.1 GenPept UniProtKB/Swiss-Prot:Q6TYB5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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