U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Spred2 sprouty-related EVH1 domain containing 2 [ Mus musculus (house mouse) ]

    Gene ID: 114716, updated on 19-Mar-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Spred2provided by MGI
    Official Full Name
    sprouty-related EVH1 domain containing 2provided by MGI
    Primary source
    MGI:MGI:2150019
    See related
    Ensembl:ENSMUSG00000045671 AllianceGenome:MGI:2150019
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables protein kinase binding activity; protein serine/threonine kinase inhibitor activity; and stem cell factor receptor binding activity. Involved in negative regulation of cell differentiation; regulation of protein modification process; and regulation of signal transduction. Acts upstream of or within negative regulation of MAPK cascade. Located in cytoplasmic vesicle and plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; heart; and sensory organ. Used to study achondroplasia. Orthologous to human SPRED2 (sprouty related EVH1 domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 1.8), adrenal adult (RPKM 1.8) and 28 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    11 A3.1; 11 12.79 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (19874442..19974026)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (19924442..20024026)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39602 Neighboring gene 40S ribosomal protein S2 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E3934 Neighboring gene STARR-seq mESC enhancer starr_28754 Neighboring gene STARR-seq mESC enhancer starr_28757 Neighboring gene STARR-seq mESC enhancer starr_28758 Neighboring gene STARR-seq mESC enhancer starr_28760 Neighboring gene STARR-positive B cell enhancer ABC_E10665 Neighboring gene STARR-seq mESC enhancer starr_28762 Neighboring gene STARR-seq mESC enhancer starr_28763 Neighboring gene STARR-seq mESC enhancer starr_28769 Neighboring gene predicted gene, 39603 Neighboring gene predicted gene, 32080 Neighboring gene actin related protein 2 Neighboring gene STARR-positive B cell enhancer ABC_E1412 Neighboring gene STARR-positive B cell enhancer ABC_E9359

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Spred2-deficiency enhances the proliferation of lung epithelial cells and alleviates pulmonary fibrosis induced by bleomycin. Kawara A, et al. Sci Rep, 2020 Oct 5. PMID 33020583, Free PMC Article
    2. Spred2 Regulates High Fat Diet-Induced Adipose Tissue Inflammation, and Metabolic Abnormalities in Mice. Ohkura T, et al. Front Immunol, 2019. PMID 30723473, Free PMC Article
    3. SPRED2 deficiency may lead to lung ischemia-reperfusion injury via ERK1/2 signaling pathway activation. Okada M, et al. Surg Today, 2018 Dec. PMID 30022248
    4. Spred2 Deficiency Exacerbates D-Galactosamine/Lipopolysaccharide -induced Acute Liver Injury in Mice via Increased Production of TNFα. Yang X, et al. Sci Rep, 2018 Jan 9. PMID 29317674, Free PMC Article
    5. Spred2-deficiecy Protects Mice from Polymicrobial Septic Peritonitis by Enhancing Inflammation and Bacterial Clearance. Itakura J, et al. Sci Rep, 2017 Oct 9. PMID 28993690, Free PMC Article

    See all (65) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. microRNA-141-3p mediates epithelial cell proliferation, apoptosis, and epithelial-mesenchymal transition and alleviates pulmonary fibrosis in mice via Spred2.
      Title: microRNA-141-3p mediates epithelial cell proliferation, apoptosis, and epithelial-mesenchymal transition and alleviates pulmonary fibrosis in mice via Spred2.
    2. LncRNA TUG1 reverses LPS-induced cell apoptosis and inflammation of macrophage via targeting MiR-221-3p/SPRED2 axis.
      Title: LncRNA TUG1 reverses LPS-induced cell apoptosis and inflammation of macrophage via targeting MiR-221-3p/SPRED2 axis.
    3. Spred2-deficiency enhances the proliferation of lung epithelial cells and alleviates pulmonary fibrosis induced by bleomycin.
      Title: Spred2-deficiency enhances the proliferation of lung epithelial cells and alleviates pulmonary fibrosis induced by bleomycin.
    4. Using established mice lines deficient for either or both Spred 1 and Spred 2, we demonstrate their role in regulating lens development by negatively regulating ERK1/2 activity.
      Title: The negative regulatory Spred1 and Spred2 proteins are required for lens and eye morphogenesis.
    5. SPRED2 deficiency impairs autophagy, leading to cardiac dysfunction and life-threatening arrhythmias.
      Title: SPRED2 deficiency elicits cardiac arrhythmias and premature death via impaired autophagy.
    6. we showed that Spred2-deficiency promotes obesity, adipose tissue inflammation, and insulin resistance, possibly via enhanced adipose tissue inflammation caused by enhanced macrophage activation.
      Title: Spred2 Regulates High Fat Diet-Induced Adipose Tissue Inflammation, and Metabolic Abnormalities in Mice.
    7. Spred2-deficiency protects mice from polymicrobial sepsis via increased activation of the ERK/MAPK pathway and subsequent increase in innate immune responses.
      Title: Spred2-deficiecy Protects Mice from Polymicrobial Septic Peritonitis by Enhancing Inflammation and Bacterial Clearance.
    8. Spred2-/- mice developed severer acute liver injury with increased levels of TNFalpha and IL-1beta in the livers.
      Title: Spred2 Deficiency Exacerbates D-Galactosamine/Lipopolysaccharide -induced Acute Liver Injury in Mice via Increased Production of TNFα.
    9. It is a known inhibitor of ERK1/2 signaling, which influences the severity of lung ischemia reperfusion injury.
      Title: SPRED2 deficiency may lead to lung ischemia-reperfusion injury via ERK1/2 signaling pathway activation.
    10. Spred2 plays an important role in the regulation of colonic epithelial cell proliferation and inflammation by potentially down-regulating the activation of ERK.
      Title: A Novel Role of Spred2 in the Colonic Epithelial Cell Homeostasis and Inflammation.
    Submit: New GeneRIF Correction See all GeneRIFs (23)

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine kinase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables stem cell factor receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of ERK1 and ERK2 cascade IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of epithelial to mesenchymal transition IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of lens fiber cell differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of peptidyl-threonine phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of peptidyl-threonine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transforming growth factor beta receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of DNA damage response, signal transduction by p53 class mediator IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of protein deacetylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    sprouty-related, EVH1 domain-containing protein 2
    Names
    sprouty protein with EVH-1 domain 2, related sequence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_033523.4 → NP_277058.1  sprouty-related, EVH1 domain-containing protein 2

      See identical proteins and their annotated locations for NP_277058.1

      Status: PROVISIONAL

      Source sequence(s)
      AL645609, AL672084
      Consensus CDS
      CCDS24454.1
      UniProtKB/Swiss-Prot
      Q924S7
      UniProtKB/TrEMBL
      Q5SRF8
      Related
      ENSMUSP00000090987.6, ENSMUST00000093298.12
      Conserved Domains (2) summary
      cd10574
      Location:12 → 124
      EVH1_SPRED-like; Sprouty-related EVH1 domain-containing-like proteins EVH1 domain
      pfam05210
      Location:299 → 397
      Sprouty; Sprouty protein (Spry)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      19874442..19974026
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006514456.5 → XP_006514519.1  sprouty-related, EVH1 domain-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      Q5SRF8
      Conserved Domains (2) summary
      cd10574
      Location:29 → 141
      EVH1_SPRED-like; Sprouty-related EVH1 domain-containing-like proteins EVH1 domain
      pfam05210
      Location:316 → 414
      Sprouty; Sprouty protein (Spry)

    2. XM_006514458.5 → XP_006514521.1  sprouty-related, EVH1 domain-containing protein 2 isoform X3

      UniProtKB/TrEMBL
      Q5SRF8
      Conserved Domains (2) summary
      cd10574
      Location:9 → 121
      EVH1_SPRED-like; Sprouty-related EVH1 domain-containing-like proteins EVH1 domain
      pfam05210
      Location:296 → 394
      Sprouty; Sprouty protein (Spry)

    3. XM_036156236.1 → XP_036012129.1  sprouty-related, EVH1 domain-containing protein 2 isoform X4

      UniProtKB/TrEMBL
      Q5SRF8
      Conserved Domains (2) summary
      cd10574
      Location:1 → 104
      EVH1_SPRED-like; Sprouty-related EVH1 domain-containing-like proteins EVH1 domain
      pfam05210
      Location:278 → 383
      Sprouty; Sprouty protein (Spry)

    4. XM_006514457.5 → XP_006514520.1  sprouty-related, EVH1 domain-containing protein 2 isoform X2

      UniProtKB/TrEMBL
      Q5SRF8
      Conserved Domains (2) summary
      cd10574
      Location:12 → 124
      EVH1_SPRED-like; Sprouty-related EVH1 domain-containing-like proteins EVH1 domain
      pfam05210
      Location:299 → 397
      Sprouty; Sprouty protein (Spry)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q924S7.1 GenPept UniProtKB/Swiss-Prot:Q924S7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous