Acap1 ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Acap1provided by MGI
Official Full Name: ArfGAP with coiled-coil, ankyrin repeat and PH domains 1provided by MGI
Primary source: MGI:MGI:2388270
See related: Ensembl:ENSMUSG00000001588 AllianceGenome:MGI:2388270
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Centb1
Summary: Predicted to enable GTPase activator activity and metal ion binding activity. Predicted to act upstream of or within lipid catabolic process and signal transduction. Predicted to be located in endosome and membrane. Is expressed in several structures, including adipose tissue; alimentary system; brain; genitourinary system; and immune system. Orthologous to human ACAP1 (ArfGAP with coiled-coil, ankyrin repeat and PH domains 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in thymus adult (RPKM 113.3), spleen adult (RPKM 55.7) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B3; 11 42.91 cM

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (69772393..69786390, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (69881566..69895568, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
acts_upstream_of_or_within lipid catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1

Names: centaurin, beta 1; cnt-b1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_153788.3 → NP_722483.2 arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1

See identical proteins and their annotated locations for NP_722483.2

Status: PROVISIONAL

Source sequence(s)

AL596185, AL845465

Consensus CDS

CCDS24919.1

UniProtKB/Swiss-Prot

Q3U441, Q571H6, Q8K2H4

Related

ENSMUSP00000001631.7, ENSMUST00000001631.7

Conserved Domains (5) summary

cd07639
Location:18 → 217

BAR_ACAP1; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with Coiled-coil, ANK repeat and PH domain containing protein 1

COG0666
Location:551 → 693

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

cd13250
Location:268 → 364

PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain

sd00045
Location:575 → 602

ANK; ANK repeat [structural motif]

cd08852
Location:405 → 524

ArfGap_ACAP1; ArfGAP domain of ACAP1 (ArfGAP with Coiled-coil, ANK repeat and PH domains 1)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

69772393..69786390 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017314457.3 → XP_017169946.1 arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 isoform X1

Conserved Domains (3) summary

cd07639
Location:18 → 217

BAR_ACAP1; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with Coiled-coil, ANK repeat and PH domain containing protein 1

cd13250
Location:268 → 364

PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain

cl28907
Location:405 → 524

ArfGap; GTPase-activating protein (GAP) for the ADP ribosylation factors (ARFs)