Dock10 dedicator of cytokinesis 10 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dock10provided by MGI
Official Full Name: dedicator of cytokinesis 10provided by MGI
Primary source: MGI:MGI:2146320
See related: Ensembl:ENSMUSG00000038608 AllianceGenome:MGI:2146320
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Jr4; Jr5; ZIZ3; Zizimin3; mKIAA0694; 9330153B10Rik; A630054M16Rik
Summary: Enables guanyl-nucleotide exchange factor activity and small GTPase binding activity. Involved in several processes, including dendritic spine morphogenesis; marginal zone B cell differentiation; and positive regulation of GTPase activity. Located in dendritic spine. Is expressed in several structures, including central nervous system; endocrine gland; retina; thymus primordium; and trigeminal nerve. Orthologous to human DOCK10 (dedicator of cytokinesis 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in spleen adult (RPKM 3.8), frontal lobe adult (RPKM 3.8) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 C5; 1 41.41 cM

Exon count:: 61

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (80478785..80736482, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (80501068..80758765, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Structural basis for the dual GTPase specificity of the DOCK10 guanine nucleotide exchange factor.
Title: Structural basis for the dual GTPase specificity of the DOCK10 guanine nucleotide exchange factor.
Dock10 Regulates Cardiac Function under Neurohormonal Stress.
Title: Dock10 Regulates Cardiac Function under Neurohormonal Stress.
Dock10 negatively regulates membrane CD23 expression; negative regulation of CD23 expression by Dock10 could play a role in B cell maturation and function
Title: Dock10 regulates CD23 expression and sustains B-cell lymphopoiesis in secondary lymphoid tissue.
DOCK10 function in dendritic spine morphogenesis is mediated mainly by Cdc42 and its downstream effectors N-WASP and PAK3, although DOCK10 is also able to activate Rac1.
Title: The RhoGEF DOCK10 is essential for dendritic spine morphogenesis.
T cells and B cells exhibited inverse expression patterns of the DOCK10 isoforms
Title: Human and mouse DOCK10 splicing isoforms with alternative first coding exon usage are differentially expressed in T and B lymphocytes.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BB240235 (e-PCR)
- UniSTS:185442

R75174 (e-PCR), detects polymorphism
- UniSTS:256630

RH125180 (e-PCR)
- UniSTS:162002

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables guanyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanyl-nucleotide exchange factor activity	IDA Inferred from Direct Assay more info	PubMed
enables small GTPase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in B cell homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dendritic spine morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in dendritic spine morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in marginal zone B cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of GTPase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in regulation of postsynapse assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynapse assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in small GTPase-mediated signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in dendritic spine	IDA Inferred from Direct Assay more info	PubMed
located_in glutamatergic synapse	IC Inferred by Curator more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IEP Inferred from Expression Pattern more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynapse	IEP Inferred from Expression Pattern more info	PubMed
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: dedicator of cytokinesis protein 10

Names: zizimin-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001285927.2 → NP_001272856.1 dedicator of cytokinesis protein 10 isoform 2

See identical proteins and their annotated locations for NP_001272856.1

Status: VALIDATED

Description

Transcript Variant: This variant (2, alternatively referred to as DOCK10.2) contains an alternate first exon and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.

Source sequence(s)

AC124672, AC132387

Consensus CDS

CCDS78626.1

UniProtKB/TrEMBL

B2RWY0

Related

ENSMUSP00000140085.2, ENSMUST00000187774.7

Conserved Domains (5) summary

cd08697
Location:659 → 848

C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins

cd11699
Location:1684 → 2129

DHR2_DOCK10; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 10

cd13267
Location:170 → 290

PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain

pfam00169
Location:170 → 277

PH; PH domain

pfam11878
Location:54 → 141

DUF3398; Domain of unknown function (DUF3398)
NM_001406554.1 → NP_001393483.1 dedicator of cytokinesis protein 10 isoform 3

Status: VALIDATED

Source sequence(s)

AC124672, AC132387
NM_001406555.1 → NP_001393484.1 dedicator of cytokinesis protein 10 isoform 4

Status: VALIDATED

Source sequence(s)

AC124672, AC132387

UniProtKB/TrEMBL

A0A087WRP5

Related

ENSMUSP00000140719.2, ENSMUST00000190983.7
NM_175291.5 → NP_780500.2 dedicator of cytokinesis protein 10 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1, alternatively referred to as DOCK10.1) encodes the longer isoform (1).

Source sequence(s)

AC124672, AC132387

Consensus CDS

CCDS48297.1

UniProtKB/Swiss-Prot

A0A087WQ86, E9QM99, F1AHI9, Q8BZN6

UniProtKB/TrEMBL

B2RWY0

Related

ENSMUSP00000077099.6, ENSMUST00000077946.12

Conserved Domains (5) summary

cd08697
Location:671 → 860

C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins

cd11699
Location:1696 → 2141

DHR2_DOCK10; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 10

cd13267
Location:182 → 302

PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain

pfam00169
Location:182 → 289

PH; PH domain

pfam11878
Location:66 → 153

DUF3398; Domain of unknown function (DUF3398)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

80478785..80736482 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030252604.2 → XP_030108464.1 dedicator of cytokinesis protein 10 isoform X20

UniProtKB/TrEMBL

B2RWY0

Conserved Domains (4) summary

cd08697
Location:761 → 950

C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins

cd13267
Location:272 → 392

PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain

pfam11878
Location:135 → 245

DUF3398; Domain of unknown function (DUF3398)

cl06123
Location:1786 → 2198

DHR2_DOCK; Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins
XM_036163169.1 → XP_036019062.1 dedicator of cytokinesis protein 10 isoform X19

UniProtKB/TrEMBL

B2RWY0

Conserved Domains (4) summary

cd08697
Location:761 → 950

C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins

cd13267
Location:272 → 392

PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain

pfam11878
Location:135 → 245

DUF3398; Domain of unknown function (DUF3398)

cl06123
Location:1786 → 2198

DHR2_DOCK; Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins
XM_006496475.5 → XP_006496538.3 dedicator of cytokinesis protein 10 isoform X18

UniProtKB/TrEMBL

B2RWY0

Conserved Domains (4) summary

cd08697
Location:761 → 950

C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins

cd13267
Location:272 → 392

PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain

pfam11878
Location:135 → 245

DUF3398; Domain of unknown function (DUF3398)

cl06123
Location:1786 → 2200

DHR2_DOCK; Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins
XM_006496470.5 → XP_006496533.3 dedicator of cytokinesis protein 10 isoform X12

UniProtKB/TrEMBL

B2RWY0

Conserved Domains (4) summary

cd08697
Location:761 → 950

C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins

cd11699
Location:1786 → 2233

DHR2_DOCK10; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 10

cd13267
Location:272 → 392

PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain

pfam11878
Location:135 → 245

DUF3398; Domain of unknown function (DUF3398)
XM_006496469.5 → XP_006496532.3 dedicator of cytokinesis protein 10 isoform X10

UniProtKB/TrEMBL

B2RWY0

Conserved Domains (4) summary

cd08697
Location:761 → 950

C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins

cd11699
Location:1786 → 2233

DHR2_DOCK10; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 10

cd13267
Location:272 → 392

PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain

pfam11878
Location:135 → 245

DUF3398; Domain of unknown function (DUF3398)
XM_030252603.2 → XP_030108463.1 dedicator of cytokinesis protein 10 isoform X13

UniProtKB/TrEMBL

B2RWY0

Conserved Domains (4) summary

cd08697
Location:761 → 950

C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins

cd11699
Location:1777 → 2222

DHR2_DOCK10; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 10

cd13267
Location:272 → 392

PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain

pfam11878
Location:135 → 245

DUF3398; Domain of unknown function (DUF3398)
XM_017319527.3 → XP_017175016.2 dedicator of cytokinesis protein 10 isoform X11

UniProtKB/TrEMBL

B2RWY0

Conserved Domains (4) summary

cd08697
Location:761 → 950

C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins

cd11699
Location:1786 → 2231

DHR2_DOCK10; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 10

cd13267
Location:272 → 392

PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain

pfam11878
Location:135 → 245

DUF3398; Domain of unknown function (DUF3398)
XM_017319532.3 → XP_017175021.2 dedicator of cytokinesis protein 10 isoform X16

UniProtKB/TrEMBL

B2RWY0

Conserved Domains (4) summary

cd08697
Location:761 → 950

C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins

cd11699
Location:1786 → 2233

DHR2_DOCK10; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 10

cd13267
Location:272 → 392

PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain

pfam11878
Location:135 → 245

DUF3398; Domain of unknown function (DUF3398)
XM_030252594.2 → XP_030108454.1 dedicator of cytokinesis protein 10 isoform X5

UniProtKB/TrEMBL

B2RWY0

Conserved Domains (4) summary

cd08697
Location:761 → 950

C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins

cd11699
Location:1777 → 2222

DHR2_DOCK10; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 10

cd13267
Location:272 → 392

PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain

pfam11878
Location:135 → 245

DUF3398; Domain of unknown function (DUF3398)
XM_006496466.5 → XP_006496529.3 dedicator of cytokinesis protein 10 isoform X4

UniProtKB/TrEMBL

B2RWY0

Conserved Domains (4) summary

cd08697
Location:761 → 950

C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins

cd11699
Location:1777 → 2224

DHR2_DOCK10; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 10

cd13267
Location:272 → 392

PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain

pfam11878
Location:135 → 245

DUF3398; Domain of unknown function (DUF3398)
XM_006496468.5 → XP_006496531.3 dedicator of cytokinesis protein 10 isoform X7

UniProtKB/TrEMBL

B2RWY0

Conserved Domains (4) summary

cd08697
Location:761 → 950

C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins

cd13267
Location:272 → 392

PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain

pfam11878
Location:135 → 245

DUF3398; Domain of unknown function (DUF3398)

cl06123
Location:1786 → 2198

DHR2_DOCK; Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins
XM_006496467.5 → XP_006496530.3 dedicator of cytokinesis protein 10 isoform X6

UniProtKB/TrEMBL

B2RWY0

Conserved Domains (4) summary

cd08697
Location:761 → 950

C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins

cd13267
Location:272 → 392

PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain

pfam11878
Location:135 → 245

DUF3398; Domain of unknown function (DUF3398)

cl06123
Location:1786 → 2200

DHR2_DOCK; Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins
XM_006496465.5 → XP_006496528.3 dedicator of cytokinesis protein 10 isoform X3

UniProtKB/TrEMBL

B2RWY0

Conserved Domains (4) summary

cd08697
Location:761 → 950

C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins

cd11699
Location:1786 → 2231

DHR2_DOCK10; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 10

cd13267
Location:272 → 392

PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain

pfam11878
Location:135 → 245

DUF3398; Domain of unknown function (DUF3398)
XM_036163168.1 → XP_036019061.1 dedicator of cytokinesis protein 10 isoform X17

UniProtKB/TrEMBL

B2RWY0

Conserved Domains (4) summary

cd08697
Location:761 → 950

C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins

cd11699
Location:1786 → 2231

DHR2_DOCK10; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 10

cd13267
Location:272 → 392

PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain

pfam11878
Location:135 → 245

DUF3398; Domain of unknown function (DUF3398)
XM_006496463.5 → XP_006496526.3 dedicator of cytokinesis protein 10 isoform X1

UniProtKB/TrEMBL

B2RWY0

Conserved Domains (4) summary

cd08697
Location:761 → 950

C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins

cd11699
Location:1786 → 2233

DHR2_DOCK10; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 10

cd13267
Location:272 → 392

PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain

pfam11878
Location:135 → 245

DUF3398; Domain of unknown function (DUF3398)
XM_006496464.5 → XP_006496527.2 dedicator of cytokinesis protein 10 isoform X2

UniProtKB/TrEMBL

B2RWY0

Conserved Domains (4) summary

cd08697
Location:670 → 859

C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins

cd11699
Location:1695 → 2142

DHR2_DOCK10; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 10

cd13267
Location:181 → 301

PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain

pfam11878
Location:44 → 154

DUF3398; Domain of unknown function (DUF3398)
XM_006496471.5 → XP_006496534.1 dedicator of cytokinesis protein 10 isoform X14

See identical proteins and their annotated locations for XP_006496534.1

UniProtKB/TrEMBL

B2RWY0

Conserved Domains (4) summary

cd08697
Location:659 → 848

C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins

cd11699
Location:1684 → 2131

DHR2_DOCK10; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 10

cd13267
Location:170 → 290

PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain

pfam11878
Location:33 → 143

DUF3398; Domain of unknown function (DUF3398)
XM_036163163.1 → XP_036019056.1 dedicator of cytokinesis protein 10 isoform X9

UniProtKB/TrEMBL

B2RWY0

Conserved Domains (4) summary

cd08697
Location:683 → 872

C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins

cd11699
Location:1708 → 2155

DHR2_DOCK10; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 10

cd13267
Location:194 → 314

PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain

pfam11878
Location:57 → 167

DUF3398; Domain of unknown function (DUF3398)
XM_017319519.3 → XP_017175008.1 dedicator of cytokinesis protein 10 isoform X8

UniProtKB/TrEMBL

B2RWY0

Conserved Domains (4) summary

cd08697
Location:684 → 873

C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins

cd11699
Location:1709 → 2156

DHR2_DOCK10; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 10

cd13267
Location:195 → 315

PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain

pfam11878
Location:58 → 168

DUF3398; Domain of unknown function (DUF3398)
XM_036163166.1 → XP_036019059.1 dedicator of cytokinesis protein 10 isoform X15

UniProtKB/TrEMBL

B2RWY0

Conserved Domains (4) summary

cd08697
Location:658 → 847

C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins

cd11699
Location:1683 → 2130

DHR2_DOCK10; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 10

cd13267
Location:169 → 289

PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain

pfam11878
Location:32 → 142

DUF3398; Domain of unknown function (DUF3398)
XM_011238683.4 → XP_011236985.1 dedicator of cytokinesis protein 10 isoform X23

UniProtKB/TrEMBL

A0A0R4J2B7

Related

ENSMUSP00000139567.2, ENSMUST00000190595.7

Conserved Domains (2) summary

cd08697
Location:156 → 345

C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins

cd11699
Location:1181 → 1628

DHR2_DOCK10; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 10