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    Hk3 hexokinase 3 [ Mus musculus (house mouse) ]

    Gene ID: 212032, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Hk3provided by MGI
    Official Full Name
    hexokinase 3provided by MGI
    Primary source
    MGI:MGI:2670962
    See related
    Ensembl:ENSMUSG00000025877 AllianceGenome:MGI:2670962
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    HK III; HK-III
    Summary
    Predicted to enable enzyme binding activity; hexokinase activity; and hormone binding activity. Predicted to be involved in several processes, including cellular glucose homeostasis; fructose 6-phosphate metabolic process; and negative regulation of hydrogen peroxide-mediated programmed cell death. Predicted to act upstream of or within phosphorylation. Located in mitochondrion. Is expressed in several structures, including adrenal gland; alimentary system; central nervous system; musculoskeletal system; and olfactory epithelium. Orthologous to human HK3 (hexokinase 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in mammary gland adult (RPKM 8.5), spleen adult (RPKM 6.6) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Hk3 in Genome Data Viewer
    Location:
    13 B1; 13 29.8 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (55153798..55169233, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (55005985..55021475, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930526F13 gene Neighboring gene predicted gene, 31313 Neighboring gene unc-5 netrin receptor A Neighboring gene ubiquitin interaction motif containing 1 Neighboring gene STARR-seq mESC enhancer starr_34599 Neighboring gene ribosomal protein L29 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E1877 Neighboring gene zinc finger protein 346 Neighboring gene STARR-positive B cell enhancer mm9_chr13:55226322-55226622 Neighboring gene predicted gene, 46415

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Chronic social stress disrupts the intracellular redistribution of brain hexokinase 3 induced by shifts in peripheral glucose levels. van der Kooij MA, et al. J Mol Med (Berl), 2022 Oct. PMID 35943566, Free PMC Article
    2. Direct neuronal glucose uptake heralds activity-dependent increases in cerebral metabolism. Lundgaard I, et al. Nat Commun, 2015 Apr 23. PMID 25904018, Free PMC Article
    3. Lactate downregulates the glycolytic enzymes hexokinase and phosphofructokinase in diverse tissues from mice. Leite TC, et al. FEBS Lett, 2011 Jan 3. PMID 21074528
    4. Chronic Activation of γ2 AMPK Induces Obesity and Reduces β Cell Function. Yavari A, et al. Cell Metab, 2016 May 10. PMID 27133129, Free PMC Article
    5. An analysis of expression patterns of genes encoding proteins with catalytic activities. Cankaya M, et al. BMC Genomics, 2007 Jul 12. PMID 17626619, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Identification of HK3 as a promising immunomodulatory and prognostic target in sepsis-induced acute lung injury.
      Title: Identification of HK3 as a promising immunomodulatory and prognostic target in sepsis-induced acute lung injury.
    2. Chronic social stress disrupts the intracellular redistribution of brain hexokinase 3 induced by shifts in peripheral glucose levels.
      Title: Chronic social stress disrupts the intracellular redistribution of brain hexokinase 3 induced by shifts in peripheral glucose levels.
    3. Hexokinase expression is highly enriched in neurons compared to astrocytes.
      Title: Direct neuronal glucose uptake heralds activity-dependent increases in cerebral metabolism.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC143940

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables fructokinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables fructokinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glucokinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glucokinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glucose binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hexokinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables hormone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphotransferase activity, alcohol group as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in carbohydrate phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fructose 6-phosphate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glucose 6-phosphate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glucose 6-phosphate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glucose metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycolytic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular glucose homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of hydrogen peroxide-mediated programmed cell death ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    hexokinase-3
    Names
    hexokinase type III
    hexokinase-C
    NP_001028417.1
    NP_001193319.1
    NP_001193320.1
    NP_001193321.1
    XP_036013853.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033245.4 → NP_001028417.1  hexokinase-3 isoform 1

      See identical proteins and their annotated locations for NP_001028417.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AC154610, AK171580, BI133441
      Consensus CDS
      CCDS26538.1
      UniProtKB/Swiss-Prot
      Q3TAX6, Q3TRM8, Q3UDP1, Q3UEA4
      UniProtKB/TrEMBL
      Q3TBG9, Q3TQE0, Q3TVQ4
      Related
      ENSMUSP00000051215.7, ENSMUST00000052949.13
      Conserved Domains (3) summary
      PLN02914
      Location:70 → 469
      PLN02914; hexokinase
      pfam00349
      Location:480 → 672
      Hexokinase_1
      pfam03727
      Location:678 → 912
      Hexokinase_2

    2. NM_001206390.1 → NP_001193319.1  hexokinase-3 isoform 1

      See identical proteins and their annotated locations for NP_001193319.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AC154610
      Consensus CDS
      CCDS26538.1
      UniProtKB/Swiss-Prot
      Q3TAX6, Q3TRM8, Q3UDP1, Q3UEA4
      UniProtKB/TrEMBL
      Q3TBG9, Q3TQE0, Q3TVQ4
      Related
      ENSMUSP00000123233.2, ENSMUST00000126234.8
      Conserved Domains (3) summary
      PLN02914
      Location:70 → 469
      PLN02914; hexokinase
      pfam00349
      Location:480 → 672
      Hexokinase_1
      pfam03727
      Location:678 → 912
      Hexokinase_2

    3. NM_001206391.1 → NP_001193320.1  hexokinase-3 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate in-frame splice site in the coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC154610
      Consensus CDS
      CCDS56884.1
      UniProtKB/TrEMBL
      E9Q8S8, Q08EC2
      Related
      ENSMUSP00000116717.2, ENSMUST00000123097.8
      Conserved Domains (3) summary
      PTZ00107
      Location:429 → 868
      PTZ00107; hexokinase; Provisional
      pfam00349
      Location:435 → 627
      Hexokinase_1; Hexokinase
      pfam03727
      Location:633 → 867
      Hexokinase_2; Hexokinase

    4. NM_001206392.1 → NP_001193321.1  hexokinase-3 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream, in-frame start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC154610
      Consensus CDS
      CCDS56883.1
      UniProtKB/TrEMBL
      E9Q3Z4, Q3TCB2
      Related
      ENSMUSP00000115227.2, ENSMUST00000153665.8
      Conserved Domains (3) summary
      PLN02914
      Location:15 → 414
      PLN02914; hexokinase
      pfam00349
      Location:425 → 617
      Hexokinase_1
      pfam03727
      Location:623 → 857
      Hexokinase_2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      55153798..55169233 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036157960.1 → XP_036013853.1  hexokinase-3 isoform X1

      UniProtKB/TrEMBL
      E9Q3Z4, Q3TCB2
      Conserved Domains (3) summary
      PLN02914
      Location:15 → 414
      PLN02914; hexokinase
      pfam00349
      Location:425 → 617
      Hexokinase_1
      pfam03727
      Location:623 → 857
      Hexokinase_2

    RNA

    1. XR_004938008.1 RNA Sequence

      Related
      ENSMUST00000132309.8
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3TRM8.2 GenPept UniProtKB/Swiss-Prot:Q3TRM8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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