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    Lsamp limbic system-associated membrane protein [ Mus musculus (house mouse) ]

    Gene ID: 268890, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Lsampprovided by MGI
    Official Full Name
    limbic system-associated membrane proteinprovided by MGI
    Primary source
    MGI:MGI:1261760
    See related
    Ensembl:ENSMUSG00000061080 AllianceGenome:MGI:1261760
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Lam; Lamp; Gm29907; 5430428I19; B130007O04Rik; D930023J12Rik
    Summary
    Acts upstream of or within locomotory exploration behavior. Predicted to be located in cytosol. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human LSAMP (limbic system associated membrane protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in cerebellum adult (RPKM 15.7), cortex adult (RPKM 9.4) and 8 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    16; 16 B4
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (39804674..42002042)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (39984254..42181679)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53954 Neighboring gene predicted gene, 36903 Neighboring gene STARR-seq mESC enhancer starr_40842 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene predicted gene, 53260 Neighboring gene predicted gene, 22543 Neighboring gene STARR-seq mESC enhancer starr_40843 Neighboring gene zinc finger protein 777 pseudogene Neighboring gene STARR-seq mESC enhancer starr_40844 Neighboring gene STARR-seq mESC enhancer starr_40845 Neighboring gene STARR-seq mESC enhancer starr_40846 Neighboring gene STARR-seq mESC enhancer starr_40847 Neighboring gene predicted gene, 52230 Neighboring gene STARR-seq mESC enhancer starr_40848 Neighboring gene STARR-seq mESC enhancer starr_40849 Neighboring gene STARR-seq mESC enhancer starr_40850 Neighboring gene STARR-seq mESC enhancer starr_40851 Neighboring gene STARR-seq mESC enhancer starr_40852 Neighboring gene STARR-seq mESC enhancer starr_40853 Neighboring gene STARR-seq mESC enhancer starr_40854 Neighboring gene STARR-seq mESC enhancer starr_40855 Neighboring gene predicted gene, 53955 Neighboring gene STARR-seq mESC enhancer starr_40856 Neighboring gene predicted gene, 53259 Neighboring gene STARR-seq mESC enhancer starr_40857 Neighboring gene STARR-seq mESC enhancer starr_40858 Neighboring gene predicted gene, 46551 Neighboring gene STARR-seq mESC enhancer starr_40859 Neighboring gene predicted gene, 52229 Neighboring gene STARR-seq mESC enhancer starr_40861 Neighboring gene 60S ribosomal protein L34 pseudogene Neighboring gene microRNA 6540 Neighboring gene growth associated protein 43

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Lsamp⁻/⁻ mice display lower sensitivity to amphetamine and have elevated 5-HT turnover. Innos J, et al. Biochem Biophys Res Commun, 2013 Jan 4. PMID 23206697
    2. Deletion of the Lsamp gene lowers sensitivity to stressful environmental manipulations in mice. Innos J, et al. Behav Brain Res, 2012 Mar 1. PMID 22155487
    3. Lower anxiety and a decrease in agonistic behaviour in Lsamp-deficient mice. Innos J, et al. Behav Brain Res, 2011 Feb 2. PMID 20888367
    4. Loss of limbic system-associated membrane protein leads to reduced hippocampal mineralocorticoid receptor expression, impaired synaptic plasticity, and spatial memory deficit. Qiu S, et al. Biol Psychiatry, 2010 Jul 15. PMID 20385375, Free PMC Article
    5. The combined impact of IgLON family proteins Lsamp and Neurotrimin on developing neurons and behavioral profiles in mouse. Singh K, et al. Brain Res Bull, 2018 Jun. PMID 29605488

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Phenotyping neurons derived from the hippocampi of Lsamp(-/-), Ntm(-/-) and Lsamp(-/-)Ntm(-/-) mice was performed in parallel with behavioral testing. Lsamp appears to be an enhancer of neurite outgrowth as premature neuritogenesis in Ntm(-/-) neurons is apparent only in the presence of Lsamp. Lsamp appeared to be a positive regulator of apoptosis in the presence of Ntm.
      Title: The combined impact of IgLON family proteins Lsamp and Neurotrimin on developing neurons and behavioral profiles in mouse.
    2. Limbic system-associated membrane protein is involved in emotional and social operating systems by complex regulation of two alternative promoters.
      Title: Lsamp is implicated in the regulation of emotional and social behavior by use of alternative promoters in the brain.
    3. Lsamp(-/-) mice are a promising model to study the neurobiological mechanisms of deviant social behaviour and adaptation impairment observed in many psychiatric disorders.
      Title: Lsamp⁻/⁻ mice display lower sensitivity to amphetamine and have elevated 5-HT turnover.
    4. Lsamp-deficient mice were less sensitive to isolation stress than their wild-type littermates.
      Title: Deletion of the Lsamp gene lowers sensitivity to stressful environmental manipulations in mice.
    5. results suggest that LAMP protein is not crucial for the general development of anatomical brain structures, but is needed for specific neural circuits that regulate anxiety-related and social behaviour.
      Title: Lower anxiety and a decrease in agonistic behaviour in Lsamp-deficient mice.
    6. lsamp knockout mice have a deficit in spatial memory acquisition and poorly sustained CA1 long-term potentiation.
      Title: Loss of limbic system-associated membrane protein leads to reduced hippocampal mineralocorticoid receptor expression, impaired synaptic plasticity, and spatial memory deficit.
    7. Genetic deletion of Lsamp causes exaggerated behavioral activation in novel environments.
      Title: Genetic deletion of Lsamp causes exaggerated behavioral activation in novel environments.
    8. genomic features of the Lsamp gene indicate an intricate mechanism of gene expression regulation that may be relevant in the context of human neuropsychiatric and neurological disorders, where LAMP expression may be altered
      Title: Characterization of the genomic structure of the mouse limbic system-associated membrane protein (Lsamp) gene.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2)  1 citation
    • Endonuclease-mediated (5) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    acts_upstream_of_or_within cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within locomotory exploration behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    limbic system-associated membrane protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347236.2 → NP_001334165.1  limbic system-associated membrane protein isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC102503, AC122207, AC124565, AC154341, AC163665
      Consensus CDS
      CCDS84234.1
      UniProtKB/Swiss-Prot
      Q8BLK3
      UniProtKB/TrEMBL
      Q3TYE5
      Related
      ENSMUSP00000097349.4, ENSMUST00000099761.10
      Conserved Domains (2) summary
      pfam13927
      Location:219 → 294
      Ig_3; Immunoglobulin domain
      cl11960
      Location:38 → 128
      Ig; Immunoglobulin domain

    2. NM_001361281.2 → NP_001348210.1  limbic system-associated membrane protein isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AC102503, AC116106, AC122207, AC124565, AC131108, AC154341, AC163665
      Consensus CDS
      CCDS88928.1
      UniProtKB/TrEMBL
      A0A087WP80
      Related
      ENSMUSP00000139667.2, ENSMUST00000187695.7
      Conserved Domains (2) summary
      pfam13927
      Location:236 → 311
      Ig_3; Immunoglobulin domain
      cl11960
      Location:55 → 145
      Ig; Immunoglobulin domain

    3. NM_001361282.2 → NP_001348211.1  limbic system-associated membrane protein isoform 4 precursor

      Status: VALIDATED

      Source sequence(s)
      AC102503, AC116106, AC122207, AC124565, AC131108, AC154341, AC163665
      Conserved Domains (2) summary
      pfam13927
      Location:236 → 311
      Ig_3; Immunoglobulin domain
      cl11960
      Location:55 → 145
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      39804674..42002042
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036159957.1 → XP_036015850.1  limbic system-associated membrane protein isoform X4

      UniProtKB/Swiss-Prot
      Q8BLK3
      Conserved Domains (3) summary
      pfam13927
      Location:249 → 325
      Ig_3; Immunoglobulin domain
      cd00096
      Location:266 → 270
      Ig; Ig strand B [structural motif]
      cl11960
      Location:69 → 159
      Ig; Immunoglobulin domain

    2. XM_030249137.2 → XP_030104997.1  limbic system-associated membrane protein isoform X1

      Conserved Domains (2) summary
      pfam13927
      Location:250 → 325
      Ig_3; Immunoglobulin domain
      cl11960
      Location:69 → 159
      Ig; Immunoglobulin domain

    3. XM_036159956.1 → XP_036015849.1  limbic system-associated membrane protein isoform X2

      Conserved Domains (3) summary
      pfam13927
      Location:249 → 325
      Ig_3; Immunoglobulin domain
      cd00096
      Location:266 → 270
      Ig; Ig strand B [structural motif]
      cl11960
      Location:69 → 159
      Ig; Immunoglobulin domain

    4. XM_030249138.2 → XP_030104998.1  limbic system-associated membrane protein isoform X3

      Conserved Domains (2) summary
      pfam13927
      Location:250 → 325
      Ig_3; Immunoglobulin domain
      cl11960
      Location:69 → 159
      Ig; Immunoglobulin domain

    5. XM_006522201.4 → XP_006522264.2  limbic system-associated membrane protein isoform X5

      UniProtKB/Swiss-Prot
      Q8BLK3
      Conserved Domains (2) summary
      pfam13927
      Location:211 → 286
      Ig_3; Immunoglobulin domain
      cl11960
      Location:30 → 120
      Ig; Immunoglobulin domain

    6. XM_036159958.1 → XP_036015851.1  limbic system-associated membrane protein isoform X6

      UniProtKB/Swiss-Prot
      Q8BLK3
      Conserved Domains (3) summary
      pfam13927
      Location:210 → 286
      Ig_3; Immunoglobulin domain
      cd00096
      Location:227 → 231
      Ig; Ig strand B [structural motif]
      cl11960
      Location:30 → 120
      Ig; Immunoglobulin domain

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_175548.3: Suppressed sequence

      Description
      NM_175548.3: This RefSeq has been removed because currently there is insufficient support for the transcript and protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BLK3.1 GenPept UniProtKB/Swiss-Prot:Q8BLK3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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