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    Lonrf3 LON peptidase N-terminal domain and ring finger 3 [ Mus musculus (house mouse) ]

    Gene ID: 74365, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Lonrf3provided by MGI
    Official Full Name
    LON peptidase N-terminal domain and ring finger 3provided by MGI
    Primary source
    MGI:MGI:1921615
    See related
    Ensembl:ENSMUSG00000016239 AllianceGenome:MGI:1921615
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rnf127; 4932412G04Rik; 5730439E01Rik; A830039N02Rik
    Summary
    Predicted to enable metal ion binding activity. Is expressed in telencephalon mantle layer and telencephalon ventricular layer. Orthologous to human LONRF3 (LON peptidase N-terminal domain and ring finger 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 2.7), placenta adult (RPKM 2.6) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    X A3.3; X 20.72 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (35592011..35630510)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (36328358..36366857)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 42406 Neighboring gene STARR-seq mESC enhancer starr_46996 Neighboring gene zinc finger, CCHC domain containing 12 Neighboring gene predicted gene 6023 Neighboring gene predicted gene, 25047 Neighboring gene predicted gene, 22364 Neighboring gene cancer/testis antigen 47

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. In vivo and in vitro investigations of heterozygous nebulin knock-out mice disclose a mild skeletal muscle phenotype. Gineste C, et al. Neuromuscul Disord, 2013 Apr. PMID 23375831
    2. High-throughput mapping of a dynamic signaling network in mammalian cells. Barrios-Rodiles M, et al. Science, 2005 Mar 11. PMID 15761153
    3. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
    4. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
    5. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    LON peptidase N-terminal domain and RING finger protein 3
    Names
    ring finger protein 127

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028894.1 → NP_083170.1  LON peptidase N-terminal domain and RING finger protein 3

      See identical proteins and their annotated locations for NP_083170.1

      Status: VALIDATED

      Source sequence(s)
      AK016522, AL450395, BC058671, BY740851
      Consensus CDS
      CCDS30059.1
      UniProtKB/Swiss-Prot
      Q9D4H7
      Related
      ENSMUSP00000016383.4, ENSMUST00000016383.10
      Conserved Domains (7) summary
      COG5152
      Location:340 → 498
      COG5152; Uncharacterized conserved protein, contains RING and CCCH-type Zn-fingers [General function prediction only]
      cd00162
      Location:460 → 499
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cl19481
      Location:560 → 746
      LON; Found in ATP-dependent protease La (LON)
      sd00006
      Location:244 → 272
      TPR; TPR repeat [structural motif]
      pfam02190
      Location:549 → 750
      LON_substr_bdg; ATP-dependent protease La (LON) substrate-binding domain
      pfam13414
      Location:243 → 309
      TPR_11; TPR repeat
      pfam14634
      Location:158 → 197
      zf-RING_5; zinc-RING finger domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      35592011..35630510
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006541404.1 → XP_006541467.1  LON peptidase N-terminal domain and RING finger protein 3 isoform X1

      Conserved Domains (6) summary
      COG5574
      Location:456 → 551
      PEX10; RING-finger-containing E3 ubiquitin ligase [Posttranslational modification, protein turnover, chaperones]
      TIGR00990
      Location:244 → 359
      3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
      sd00006
      Location:244 → 272
      TPR; TPR repeat [structural motif]
      cd16513
      Location:159 → 197
      RING1-HC_LONFs; RING finger 1, HC subclass, found in the LON peptidase N-terminal domain and RING finger proteins family
      cd16514
      Location:510 → 551
      RING2-HC_LONFs; RING finger 2, HC subclass, found in the LON peptidase N-terminal domain and RING finger proteins family
      pfam02190
      Location:601 → 802
      LON_substr_bdg; ATP-dependent protease La (LON) substrate-binding domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D4H7.1 GenPept UniProtKB/Swiss-Prot:Q9D4H7

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