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    Pex16 peroxisomal biogenesis factor 16 [ Mus musculus (house mouse) ]

    Gene ID: 18633, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Pex16provided by MGI
    Official Full Name
    peroxisomal biogenesis factor 16provided by MGI
    Primary source
    MGI:MGI:1338829
    See related
    Ensembl:ENSMUSG00000027222 AllianceGenome:MGI:1338829
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable protein C-terminus binding activity. Predicted to be involved in peroxisome organization and protein to membrane docking. Predicted to act upstream of or within protein import into peroxisome matrix. Located in peroxisomal membrane. Human ortholog(s) of this gene implicated in peroxisomal biogenesis disorder and peroxisome biogenesis disorder 8A. Orthologous to human PEX16 (peroxisomal biogenesis factor 16). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 68.1), subcutaneous fat pad adult (RPKM 52.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    2 E1; 2 50.98 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (92205043..92211563)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (92374676..92381220)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene PHD finger protein 21A Neighboring gene 60S ribosomal protein L34 pseudogene Neighboring gene STARR-seq mESC enhancer starr_05138 Neighboring gene STARR-positive B cell enhancer ABC_E1247 Neighboring gene STARR-positive B cell enhancer ABC_E4480 Neighboring gene LARGE xylosyl- and glucuronyltransferase 2 Neighboring gene mitogen-activated protein kinase 8 interacting protein 1 Neighboring gene microRNA 7000 Neighboring gene Frey regulator of sperm-oocyte fusion 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Peroxisome-derived lipids regulate adipose thermogenesis by mediating cold-induced mitochondrial fission. Park H, et al. J Clin Invest, 2019 Feb 1. PMID 30511960, Free PMC Article
    2. Mice with endogenous TDP-43 mutations exhibit gain of splicing function and characteristics of amyotrophic lateral sclerosis. Fratta P, et al. EMBO J, 2018 Jun 1. PMID 29764981, Free PMC Article
    3. Peroxisome synthesis in the absence of preexisting peroxisomes. South ST, et al. J Cell Biol, 1999 Jan 25. PMID 9922452, Free PMC Article
    4. Proteomic analysis of rat liver peroxisome: presence of peroxisome-specific isozyme of Lon protease. Kikuchi M, et al. J Biol Chem, 2004 Jan 2. PMID 14561759
    5. Functional genomic landscape of cancer-intrinsic evasion of killing by T cells. Lawson KA, et al. Nature, 2020 Oct. PMID 32968282, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3) 
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in ER-dependent peroxisome localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ER-dependent peroxisome organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peroxisome membrane biogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peroxisome organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in peroxisome organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein import into peroxisome matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein import into peroxisome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein targeting to peroxisome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein to membrane docking ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in peroxisomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in peroxisomal membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in peroxisomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    peroxisomal biogenesis factor 16
    Names
    peroxin-16
    peroxisomal membrane protein PEX16

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001420534.1 → NP_001407463.1  peroxisomal biogenesis factor 16 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) encodes the longest isoform (3).
      Source sequence(s)
      AL731709

    2. NM_001420535.1 → NP_001407464.1  peroxisomal biogenesis factor 16 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL731709

    3. NM_001420536.1 → NP_001407465.1  peroxisomal biogenesis factor 16 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL731709

    4. NM_145122.3 → NP_660104.2  peroxisomal biogenesis factor 16 isoform 1

      See identical proteins and their annotated locations for NP_660104.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AL731709
      Consensus CDS
      CCDS16444.1
      UniProtKB/Swiss-Prot
      Q3UPY2, Q91XC9
      UniProtKB/TrEMBL
      Q3TRJ6
      Related
      ENSMUSP00000028650.9, ENSMUST00000028650.9
      Conserved Domains (1) summary
      pfam08610
      Location:11 → 329
      Pex16; Peroxisomal membrane protein (Pex16)

    RNA

    1. NR_185193.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL731709

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      92205043..92211563
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036159535.1 → XP_036015428.1  peroxisomal biogenesis factor 16 isoform X1

      Conserved Domains (1) summary
      pfam08610
      Location:10 → 181
      Pex16; Peroxisomal membrane protein (Pex16)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91XC9.2 GenPept UniProtKB/Swiss-Prot:Q91XC9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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