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    Gpr161 G protein-coupled receptor 161 [ Mus musculus (house mouse) ]

    Gene ID: 240888, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Gpr161provided by MGI
    Official Full Name
    G protein-coupled receptor 161provided by MGI
    Primary source
    MGI:MGI:2685054
    See related
    Ensembl:ENSMUSG00000040836 AllianceGenome:MGI:2685054
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    vl; Gm208; Gm208Gpr
    Summary
    Enables G protein-coupled receptor activity. Involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway and negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning. Located in cilium and recycling endosome. Is expressed in several structures, including central nervous system; eye; and limb. Orthologous to human GPR161 (G protein-coupled receptor 161). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in whole brain E14.5 (RPKM 9.4), CNS E18 (RPKM 9.0) and 14 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    1 H2.2; 1 72.64 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (165108760..165154314)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (165281184..165326747)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene T-box 19 Neighboring gene STARR-seq mESC enhancer starr_02894 Neighboring gene SFT2 domain containing 2 Neighboring gene STARR-seq mESC enhancer starr_02896 Neighboring gene TIP41, TOR signalling pathway regulator-like (S. cerevisiae) Neighboring gene STARR-seq mESC enhancer starr_02898 Neighboring gene DDB1 and CUL4 associated factor 6 Neighboring gene STARR-seq mESC enhancer starr_02900 Neighboring gene STARR-positive B cell enhancer ABC_E2016 Neighboring gene STARR-positive B cell enhancer ABC_E119 Neighboring gene predicted gene, 24637 Neighboring gene mitochondrial pyruvate carrier 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. In vitro expression of neural tube pathology in the vl mutant mouse. Wilson DB, et al. J Neuropathol Exp Neurol, 1993 May. PMID 8492142
    2. Closure of the posterior neuropore in the vl mutant mouse. Wilson DB, et al. Anat Embryol (Berl), 1988. PMID 3223614
    3. Ultrastructural defects in the apical neural folds in mutant embryos with spina bifida. Wilson DB, et al. Acta Neuropathol, 1989. PMID 2686337
    4. Ubiquitin chains earmark GPCRs for BBSome-mediated removal from cilia. Shinde SR, et al. J Cell Biol, 2020 Dec 7. PMID 33185668, Free PMC Article
    5. Congenital Cataract in Gpr161vl/vl Mice Is Modified by Proximal Chromosome 15. Li BI, et al. PLoS One, 2017. PMID 28135291, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ciliary and extraciliary Gpr161 pools repress hedgehog signaling in a tissue-specific manner.
      Title: Ciliary and extraciliary Gpr161 pools repress hedgehog signaling in a tissue-specific manner.
    2. Ubiquitin chains earmark GPCRs for BBSome-mediated removal from cilia.
      Title: Ubiquitin chains earmark GPCRs for BBSome-mediated removal from cilia.
    3. Derepression of sonic hedgehog signaling upon Gpr161 deletion unravels forebrain and ventricular abnormalities.
      Title: Derepression of sonic hedgehog signaling upon Gpr161 deletion unravels forebrain and ventricular abnormalities.
    4. Gpr161 restricts cerebellar granule cell progenitor production by preventing premature and sonic hedgehog-dependent pathway activity, highlighting the importance of basal pathway suppression in tumorigenesis
      Title: Basal Suppression of the Sonic Hedgehog Pathway by the G-Protein-Coupled Receptor Gpr161 Restricts Medulloblastoma Pathogenesis.
    5. Gpr161 promotes forelimb formation, regulates limb patterning, prevents periarticular chondrocyte proliferation and drives osteoblastogenesis in intramembranous bones in a cilium-dependent manner.
      Title: The G protein-coupled receptor Gpr161 regulates forelimb formation, limb patterning and skeletal morphogenesis in a primary cilium-dependent manner.
    6. These studies demonstrate that modification of the Gpr161vl/vl cataract phenotype is likely due to genetic variants in at least one of three closely linked candidate genes on proximal Chromosome 15.
      Title: Congenital Cataract in Gpr161vl/vl Mice Is Modified by Proximal Chromosome 15.
    7. Smoothened determines beta-arrestin-mediated removal of the G protein-coupled receptor Gpr161 from the primary cilium.
      Title: Smoothened determines β-arrestin-mediated removal of the G protein-coupled receptor Gpr161 from the primary cilium.
    8. Gpr161 is a G-protein coupled receptor that regulates the retinoic acid and canonical Wnt pathways during neurulation
      Title: The orphan GPCR, Gpr161, regulates the retinoic acid and canonical Wnt pathways during neurulation.
    9. Complete loss of Gpr161 in mouse causes midgestation lethality and increased Shh signaling in the neural tube, phenocopying Tulp3/IFT-A mutants.
      Title: The ciliary G-protein-coupled receptor Gpr161 negatively regulates the Sonic hedgehog pathway via cAMP signaling.
    10. Gpr161 is required for left-right patterning.
      Title: The orphan G protein-coupled receptor 161 is required for left-right patterning.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    Phenotypes

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    Associated conditions

    Description Tests
    vacuolated lens
    GeneReviews: Not available

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Spontaneous (1) 
    • Targeted (5)  1 citation
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cilium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in glial cell projection IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuron projection IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in recycling endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in recycling endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    G-protein coupled receptor 161

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081126.2 → NP_001074595.1  G-protein coupled receptor 161 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC116374, AK145635, BE991962, BY731738, CN721893
      UniProtKB/Swiss-Prot
      B2RPY5
      Conserved Domains (2) summary
      pfam00001
      Location:73 → 353
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:64 → 270
      7tm_4; Olfactory receptor

    2. NM_001310429.1 → NP_001297358.1  G-protein coupled receptor 161 isoform 2

      See identical proteins and their annotated locations for NP_001297358.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC116374, BC137659, BE991962, BY731738, CN721893
      Consensus CDS
      CCDS83621.1
      UniProtKB/Swiss-Prot
      B0L0L8, B2RPY5, J3QN69, Q80T48
      Related
      ENSMUSP00000136621.3, ENSMUST00000178700.8
      Conserved Domains (2) summary
      pfam00001
      Location:60 → 340
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:51 → 257
      7tm_4; Olfactory receptor

    3. NM_001310430.1 → NP_001297359.1  G-protein coupled receptor 161 isoform 3

      See identical proteins and their annotated locations for NP_001297359.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region, and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC116374, AK145635, BE991962
      Consensus CDS
      CCDS78732.1
      UniProtKB/TrEMBL
      A0A140T8Q9
      Related
      ENSMUSP00000107077.3, ENSMUST00000111450.3
      Conserved Domains (1) summary
      cd15214
      Location:28 → 334
      7tmA_GPR161; orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      165108760..165154314
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006496851.5 → XP_006496914.1  G-protein coupled receptor 161 isoform X1

      See identical proteins and their annotated locations for XP_006496914.1

      UniProtKB/TrEMBL
      A0A140T8Q9
      Conserved Domains (1) summary
      cd15214
      Location:28 → 334
      7tmA_GPR161; orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. XM_011238821.4 → XP_011237123.1  G-protein coupled receptor 161 isoform X1

      See identical proteins and their annotated locations for XP_011237123.1

      UniProtKB/TrEMBL
      A0A140T8Q9
      Conserved Domains (1) summary
      cd15214
      Location:28 → 334
      7tmA_GPR161; orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors

    3. XM_006496850.5 → XP_006496913.1  G-protein coupled receptor 161 isoform X1

      See identical proteins and their annotated locations for XP_006496913.1

      UniProtKB/TrEMBL
      A0A140T8Q9
      Conserved Domains (1) summary
      cd15214
      Location:28 → 334
      7tmA_GPR161; orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors

    4. XM_006496852.5 → XP_006496915.1  G-protein coupled receptor 161 isoform X1

      See identical proteins and their annotated locations for XP_006496915.1

      UniProtKB/TrEMBL
      A0A140T8Q9
      Conserved Domains (1) summary
      cd15214
      Location:28 → 334
      7tmA_GPR161; orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B2RPY5.1 GenPept UniProtKB/Swiss-Prot:B2RPY5

    Gene LinkOut

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