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    Metap2 methionine aminopeptidase 2 [ Mus musculus (house mouse) ]

    Gene ID: 56307, updated on 23-Jun-2021

    Summary

    Official Symbol
    Metap2provided by MGI
    Official Full Name
    methionine aminopeptidase 2provided by MGI
    Primary source
    MGI:MGI:1929701
    See related
    Ensembl:ENSMUSG00000036112
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    p6; p67; Amp2; Mnpep; p67eIF2; AI047573; AL024412; AU014659; 4930584B20Rik; A930035J23Rik
    Expression
    Broad expression in liver E14 (RPKM 47.5), liver E14.5 (RPKM 37.1) and 20 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Metap2 in Genome Data Viewer
    Location:
    10; 10 C2
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (93694351..93732952, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (93858489..93897090, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (93321234..93353947, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene farnesyl diphosphate synthetase pseudogene Neighboring gene predicted gene, 26239 Neighboring gene ubiquitin specific peptidase 44 Neighboring gene microRNA 331 Neighboring gene vezatin, adherens junctions transmembrane protein Neighboring gene mitochondrial inner membrane protease subunit 1 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC102452

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables aminopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metalloaminopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metalloexopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in N-terminal protein amino acid modification ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptidyl-methionine modification ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein processing ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    methionine aminopeptidase 2
    Names
    MAP 2
    eIF-2-associated p67
    initiation factor 2-associated 67 kDa glycoprotein
    initiation factor 2-associated protein (p67)
    metAP 2
    peptidase M 2
    NP_062622.1
    XP_006513959.1
    XP_006513960.1
    XP_017169521.1
    XP_036011787.1
    XP_036011788.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019648.3NP_062622.1  methionine aminopeptidase 2

      See identical proteins and their annotated locations for NP_062622.1

      Status: VALIDATED

      Source sequence(s)
      AC124686, AF434712, AK165301
      Consensus CDS
      CCDS48673.1
      UniProtKB/Swiss-Prot
      O08663
      UniProtKB/TrEMBL
      Q58E65
      Related
      ENSMUSP00000138006.2, ENSMUST00000180840.8
      Conserved Domains (1) summary
      PTZ00053
      Location:107478
      PTZ00053; methionine aminopeptidase 2; Provisional

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      93694351..93732952 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006513896.4XP_006513959.1  methionine aminopeptidase 2 isoform X1

      See identical proteins and their annotated locations for XP_006513959.1

      UniProtKB/Swiss-Prot
      O08663
      UniProtKB/TrEMBL
      Q58E65
      Conserved Domains (1) summary
      PTZ00053
      Location:107478
      PTZ00053; methionine aminopeptidase 2; Provisional
    2. XM_017314032.2XP_017169521.1  methionine aminopeptidase 2 isoform X2

      Conserved Domains (1) summary
      PTZ00053
      Location:106477
      PTZ00053; methionine aminopeptidase 2; Provisional
    3. XM_006513897.5XP_006513960.1  methionine aminopeptidase 2 isoform X1

      See identical proteins and their annotated locations for XP_006513960.1

      UniProtKB/Swiss-Prot
      O08663
      UniProtKB/TrEMBL
      Q58E65
      Related
      ENSMUSP00000138083.2, ENSMUST00000181217.8
      Conserved Domains (1) summary
      PTZ00053
      Location:107478
      PTZ00053; methionine aminopeptidase 2; Provisional
    4. XM_036155894.1XP_036011787.1  methionine aminopeptidase 2 isoform X1

      Conserved Domains (1) summary
      PTZ00053
      Location:107478
      PTZ00053; methionine aminopeptidase 2; Provisional
    5. XM_036155895.1XP_036011788.1  methionine aminopeptidase 2 isoform X2

      Conserved Domains (1) summary
      PTZ00053
      Location:106477
      PTZ00053; methionine aminopeptidase 2; Provisional
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