Ro60 Ro60, Y RNA binding protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ro60provided by MGI
Official Full Name: Ro60, Y RNA binding proteinprovided by MGI
Primary source: MGI:MGI:106652
See related: Ensembl:ENSMUSG00000018199 AllianceGenome:MGI:106652
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ssa; Ssa2; Trove2; SS-A/Ro; 1810007I17Rik; A530054J02Rik
Summary: Enables U2 snRNA binding activity. Acts upstream of or within several processes, including cilium assembly; response to UV; and smoothened signaling pathway. Located in cytoplasm and nucleus. Part of ribonucleoprotein complex. Is expressed in embryo. Used to study systemic lupus erythematosus. Orthologous to human RO60 (Ro60, Y RNA binding protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in CNS E11.5 (RPKM 5.5), CNS E18 (RPKM 5.4) and 20 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 F; 1 62.54 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (143626528..143652794, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (143750790..143777063, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

IL-33/ST2 Activation Is involved in Ro60-Regulated Photosensitivity in Cutaneous Lupus Erythematosus.
Title: IL-33/ST2 Activation Is involved in Ro60-Regulated Photosensitivity in Cutaneous Lupus Erythematosus.
Ro60 ameliorated the severity of dextran sodium sulfate -induced colitis in mice by repressing inflammation, fibrosis, angiogenesis, and the production of reactive oxygen species
Title: Ro60 Inhibits Colonic Inflammation and Fibrosis in a Mouse Model of Dextran Sulfate Sodium-Induced Colitis.
These data support the hypothesis that antibodies to Ro274 deposit in salivary glands can enter intact salivary gland cells and are involved in the dysregulation of salivary flow in SS.
Title: Passive transfer of antibodies to the linear epitope 60 kD Ro 273-289 induces features of Sjögren's syndrome in naive mice.
Restricted specificity of intermolecular spreading to endogenous La (SS-B) and 60 kDa Ro (SS-A) in experimental autoimmunity.
Title: Restricted specificity of intermolecular spreading to endogenous La (SS-B) and 60 kDa Ro (SS-A) in experimental autoimmunity.
differences in the epitope spreading after 60 kDa Ro peptide immunization in several strains of mice
Title: Immunization with peptides from 60 kDa Ro in diverse mouse strains.
Ro protein has a role in preventing an autoimmune syndrome characterized by anti-ribosome antibodies, anti-chromatin antibodies, and glomerulonephritis
Title: A lupus-like syndrome develops in mice lacking the Ro 60-kDa protein, a major lupus autoantigen.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

U66843 (e-PCR)
- UniSTS:178445

AI646302 (e-PCR)
- UniSTS:178446

NoName (e-PCR)
- UniSTS:234230

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA binding	ISO Inferred from Sequence Orthology more info
enables U2 snRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables misfolded RNA binding	ISO Inferred from Sequence Orthology more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell projection organization	IEA Inferred from Electronic Annotation more info
involved_in cellular response to interferon-alpha	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cilium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within immune system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to UV	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to UV	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within smoothened signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of ribonucleoprotein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of ribonucleoprotein complex	IDA Inferred from Direct Assay more info	PubMed
part_of ribonucleoprotein complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: RNA-binding protein Ro60

Names: 60 kDa Ro protein; 60 kDa SS-A/Ro ribonucleoprotein; 60 kDa ribonucleoprotein Ro; Sjogren syndrome antigen A2; TROVE domain family, member 2; roRNP

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013835.2 → NP_038863.1 RNA-binding protein Ro60

See identical proteins and their annotated locations for NP_038863.1

Status: VALIDATED

Source sequence(s)

AL592403, BQ032951, BY121097, U66843

Consensus CDS

CCDS15345.1

UniProtKB/Swiss-Prot

O08848, Q9QYD8

UniProtKB/TrEMBL

Q3TJ75, Q7TT40, Q80W12, Q8R562

Related

ENSMUSP00000125623.2, ENSMUST00000159879.2

Conserved Domains (2) summary

cd00198
Location:372 → 489

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

pfam05731
Location:16 → 369

TROVE; TROVE domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

143626528..143652794 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017319451.3 → XP_017174940.1 RNA-binding protein Ro60 isoform X1

UniProtKB/Swiss-Prot

O08848, Q9QYD8

UniProtKB/TrEMBL

Q3TJ75, Q7TT40, Q80W12, Q8R562

Conserved Domains (2) summary

cd00198
Location:372 → 489

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

pfam05731
Location:16 → 369

TROVE; TROVE domain