Grk5 G protein-coupled receptor kinase 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Grk5provided by MGI
Official Full Name: G protein-coupled receptor kinase 5provided by MGI
Primary source: MGI:MGI:109161
See related: Ensembl:ENSMUSG00000003228 AllianceGenome:MGI:109161
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gprk5
Summary: Predicted to enable beta-adrenergic receptor kinase activity and protein serine/threonine kinase activity. Involved in fat cell differentiation. Predicted to be located in cytosol; nucleus; and plasma membrane. Predicted to be active in cytoplasm. Is expressed in several structures, including central nervous system; eye; genitourinary system; gut; and immune system. Orthologous to human GRK5 (G protein-coupled receptor kinase 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in lung adult (RPKM 3.7), subcutaneous fat pad adult (RPKM 2.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 D3; 19 56.52 cM

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (60877995..61084406)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (60889560..61095968)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Genetic Arg-304-His substitution in GRK5 protects against sepsis progression by alleviating NF-kappaB-mediated inflammation.
Title: Genetic Arg-304-His substitution in GRK5 protects against sepsis progression by alleviating NF-κB-mediated inflammation.
GRK5-mediated inflammation and fibrosis exert cardioprotective effects during the acute phase of myocardial infarction.
Title: GRK5-mediated inflammation and fibrosis exert cardioprotective effects during the acute phase of myocardial infarction.
G protein-coupled receptor kinase 5 (GRK5) contributes to impaired cardiac function and immune cell recruitment in post-ischemic heart failure.
Title: G protein-coupled receptor kinase 5 (GRK5) contributes to impaired cardiac function and immune cell recruitment in post-ischemic heart failure.
A peptide of the N terminus of GRK5 attenuates pressure-overload hypertrophy and heart failure.
Title: A peptide of the N terminus of GRK5 attenuates pressure-overload hypertrophy and heart failure.
GRK5 is a regulator of fibroblast activation and cardiac fibrosis.
Title: GRK5 is a regulator of fibroblast activation and cardiac fibrosis.
GRK5 Controls SAP97-Dependent Cardiotoxic beta1 Adrenergic Receptor-CaMKII Signaling in Heart Failure.
Title: GRK5 Controls SAP97-Dependent Cardiotoxic β(1) Adrenergic Receptor-CaMKII Signaling in Heart Failure.
GRK5 deficiency contributes to the pathogenesis of Alzheimer's disease by influencing the hyperphosphorylation of tau through the activation of GSK3beta.
Title: GRK5 influences the phosphorylation of tau via GSK3β and contributes to Alzheimer's disease.
These data indicate that GRK2, GRK5 and GRK6 redundantly modulate Smo-GATA crosstalk in fetal mouse hearts, orchestrating transcriptional pathways previously linked to clinical and experimental atrioventricular canal defects
Title: G-protein receptor kinases 2, 5 and 6 redundantly modulate Smoothened-GATA transcriptional crosstalk in fetal mouse hearts.
GRK5 is critical for maintaining normal mTORC1 signaling and connectivity in medial prefrontal cortex and normal social behavior.
Title: GRK5 Regulates Social Behavior Via Suppression of mTORC1 Signaling in Medial Prefrontal Cortex.
Along with other supporting evidence, the authors propose that GRK5 deficiency selectively renders basal forebrain cholinergic neurons more vulnerable to degeneration.
Title: GRK5 Deficiency Leads to Selective Basal Forebrain Cholinergic Neuronal Vulnerability.

Submit: New GeneRIF Correction See all GeneRIFs (35)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (6) 1 citation
Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Gprk5 (e-PCR), detects polymorphism
- UniSTS:186226

D19Jpk2 (e-PCR), detects polymorphism
- UniSTS:142213

UniSTS:496009 (e-PCR)
- UniSTS:496009

Grk5 (e-PCR), detects polymorphism
- UniSTS:496009

RH136594 (e-PCR)
- UniSTS:210574

D19Dcr72 (e-PCR), detects polymorphism
- UniSTS:532392

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables G protein-coupled receptor kinase activity	IEA Inferred from Electronic Annotation more info
enables beta-adrenergic receptor kinase activity	ISO Inferred from Sequence Orthology more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in desensitization of G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in fat cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in protein autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in regulation of signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in tachykinin receptor signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: G protein-coupled receptor kinase 5

Names: g protein-coupled receptor kinase GRK5

NP_061357.3

EC 2.7.11.16

XP_006526760.1

EC 2.7.11.16

XP_011245451.1

EC 2.7.11.16

XP_017173555.2

EC 2.7.11.16

XP_036017332.1

EC 2.7.11.16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_018869.3 → NP_061357.3 G protein-coupled receptor kinase 5

See identical proteins and their annotated locations for NP_061357.3

Status: VALIDATED

Source sequence(s)

AK135076, AK161821, AW456000, BY289760

Consensus CDS

CCDS29945.1

UniProtKB/Swiss-Prot

O70292, O70297, Q8VEB1

UniProtKB/TrEMBL

Q3TST4

Related

ENSMUSP00000003313.9, ENSMUST00000003313.10

Conserved Domains (3) summary

smart00220
Location:186 → 448

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd05632
Location:183 → 495

STKc_GRK5; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 5

cl02565
Location:53 → 175

RGS; Regulator of G protein signaling (RGS) domain superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000085.7 Reference GRCm39 C57BL/6J

Range

60877995..61084406

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006526697.5 → XP_006526760.1 G protein-coupled receptor kinase 5 isoform X1

Conserved Domains (2) summary

cd05632
Location:151 → 463

STKc_GRK5; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 5

cl02565
Location:21 → 143

RGS; Regulator of G protein signaling (RGS) domain superfamily
XM_036161439.1 → XP_036017332.1 G protein-coupled receptor kinase 5 isoform X3

Conserved Domains (1) summary

cl21453
Location:26 → 303

PKc_like; Protein Kinases, catalytic domain
XM_011247149.4 → XP_011245451.1 G protein-coupled receptor kinase 5 isoform X2

Conserved Domains (2) summary

cd05632
Location:136 → 448

STKc_GRK5; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 5

cl02565
Location:6 → 128

RGS; Regulator of G protein signaling (RGS) domain superfamily
XM_017318066.3 → XP_017173555.2 G protein-coupled receptor kinase 5 isoform X4

Conserved Domains (2) summary

cd05632
Location:19 → 331

STKc_GRK5; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 5

cl02565
Location:1 → 19

RGS; Regulator of G protein signaling (RGS) domain superfamily