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    Cdipt CDP-diacylglycerol--inositol 3-phosphatidyltransferase [ Mus musculus (house mouse) ]

    Gene ID: 52858, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Cdiptprovided by MGI
    Official Full Name
    CDP-diacylglycerol--inositol 3-phosphatidyltransferaseprovided by MGI
    Primary source
    MGI:MGI:105491
    See related
    Ensembl:ENSMUSG00000030682 AllianceGenome:MGI:105491
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pis; Pis1; D7Bwg0575e; 9530042F15Rik
    Summary
    Predicted to enable several functions, including CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity; diacylglycerol binding activity; and manganese ion binding activity. Predicted to be involved in CDP-diacylglycerol metabolic process and phosphatidylinositol biosynthetic process. Predicted to act upstream of or within phospholipid biosynthetic process. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus. Is expressed in musculature; nervous system; and urinary system. Orthologous to human CDIPT (CDP-diacylglycerol--inositol 3-phosphatidyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in large intestine adult (RPKM 67.2), duodenum adult (RPKM 64.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cdipt in Genome Data Viewer
    Location:
    7 F3; 7 69.26 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (126575630..126579671)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (126976458..126980499)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene seizure related 6 homolog like 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:134119536-134119823 Neighboring gene CDIP transferase, opposite strand Neighboring gene major vault protein Neighboring gene STARR-seq mESC enhancer starr_20161 Neighboring gene STARR-positive B cell enhancer ABC_E2850 Neighboring gene PAXIP1 associated glutamate rich protein 1A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Characterization of the null murine sodium/myo-inositol cotransporter 1 (Smit1 or Slc5a3) phenotype: myo-inositol rescue is independent of expression of its cognate mitochondrial ribosomal protein subunit 6 (Mrps6) gene and of phosphatidylinositol levels in neonatal brain. Buccafusca R, et al. Mol Genet Metab, 2008 Sep-Oct. PMID 18675571
    2. Interactome Analysis Reveals Regulator of G Protein Signaling 14 (RGS14) is a Novel Calcium/Calmodulin (Ca(2+)/CaM) and CaM Kinase II (CaMKII) Binding Partner. Evans PR, et al. J Proteome Res, 2018 Apr 6. PMID 29518331, Free PMC Article
    3. RNA binding proteins co-localize with small tau inclusions in tauopathy. Maziuk BF, et al. Acta Neuropathol Commun, 2018 Aug 1. PMID 30068389, Free PMC Article
    4. Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Brady KP, et al. Genome Res, 1997 Nov. PMID 9371744, Free PMC Article
    5. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (2) 
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables alcohol binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables carbohydrate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables diacylglycerol binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables manganese ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphotransferase activity, for other substituted phosphate groups IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in CDP-diacylglycerol metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphatidylinositol biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidylinositol biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within phospholipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phospholipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    CDP-diacylglycerol--inositol 3-phosphatidyltransferase
    Names
    PI synthase
    phosphatidylinositol synthase
    ptdIns synthase
    NP_001334585.1
    NP_001366189.1
    NP_080914.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347656.2 → NP_001334585.1  CDP-diacylglycerol--inositol 3-phosphatidyltransferase isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice junction compared to variant 1, that causes a frameshift. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC122863
      Consensus CDS
      CCDS85418.1
      UniProtKB/TrEMBL
      A0A0U1RNI6, A0A0U1RPV3
      Related
      ENSMUSP00000146137.2, ENSMUST00000206346.2

    2. NM_001379260.1 → NP_001366189.1  CDP-diacylglycerol--inositol 3-phosphatidyltransferase isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3).
      Source sequence(s)
      AC122863
      UniProtKB/TrEMBL
      A0A0U1RP13
      Conserved Domains (1) summary
      pfam01066
      Location:10 → 72
      CDP-OH_P_transf; CDP-alcohol phosphatidyltransferase

    3. NM_026638.4 → NP_080914.1  CDP-diacylglycerol--inositol 3-phosphatidyltransferase isoform 1

      See identical proteins and their annotated locations for NP_080914.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AC122863
      Consensus CDS
      CCDS21853.1
      UniProtKB/Swiss-Prot
      Q8VDP6
      UniProtKB/TrEMBL
      A0A0U1RP13
      Related
      ENSMUSP00000032920.4, ENSMUST00000032920.5
      Conserved Domains (1) summary
      pfam01066
      Location:10 → 72
      CDP-OH_P_transf; CDP-alcohol phosphatidyltransferase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      126575630..126579671
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VDP6.1 GenPept UniProtKB/Swiss-Prot:Q8VDP6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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