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    Il7 interleukin 7 [ Mus musculus (house mouse) ]

    Gene ID: 16196, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Il7provided by MGI
    Official Full Name
    interleukin 7provided by MGI
    Primary source
    MGI:MGI:96561
    See related
    Ensembl:ENSMUSG00000040329 AllianceGenome:MGI:96561
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Il-7; hlb368; A630026I06Rik
    Summary
    The protein encoded by this gene is a hematopoietic growth factor important for B and T cell development. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]
    Expression
    Broad expression in thymus adult (RPKM 2.5), spleen adult (RPKM 1.2) and 17 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Il7 in Genome Data Viewer
    Location:
    3 A1; 3 2.02 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (7637088..7678820, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (7572028..7613760, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 23592 Neighboring gene zinc finger, C2HC-type containing 1A Neighboring gene STARR-seq mESC enhancer starr_06837 Neighboring gene STARR-seq mESC enhancer starr_06838 Neighboring gene STARR-seq mESC enhancer starr_06840 Neighboring gene predicted gene, 16685 Neighboring gene STARR-seq mESC enhancer starr_06841 Neighboring gene STARR-seq mESC enhancer starr_06842 Neighboring gene STARR-seq mESC enhancer starr_06843 Neighboring gene STARR-seq mESC enhancer starr_06844 Neighboring gene STARR-seq mESC enhancer starr_06846 Neighboring gene STARR-seq mESC enhancer starr_06847 Neighboring gene RIKEN cDNA 1700010I02 gene Neighboring gene predicted gene, 29747

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. IL-7 Deficiency Exacerbates Atopic Dermatitis in NC/Nga Mice. Park HJ, et al. Int J Mol Sci, 2023 Jun 9. PMID 37373104, Free PMC Article
    2. Selective dependence on IL-7 for antigen-specific CD8 T cell responses during airway influenza infection. Sheikh A, et al. Sci Rep, 2022 Jan 7. PMID 34997007, Free PMC Article
    3. Prosurvival IL-7-Stimulated Weak Strength of mTORC1-S6K Controls T Cell Memory via Transcriptional FOXO1-TCF1-Id3 and Metabolic AMPKα1-ULK1-ATG7 Pathways. Xu A, et al. J Immunol, 2022 Jan 1. PMID 34872976
    4. Interleukin-7 aggravates myocardial ischaemia/reperfusion injury by regulating macrophage infiltration and polarization. Yan M, et al. J Cell Mol Med, 2021 Nov. PMID 34581005, Free PMC Article
    5. Interleukin-7 protects CD8(+) T cells from adenosine-mediated immunosuppression. Koyas A, et al. Sci Signal, 2021 Mar 16. PMID 33727336

    See all (396) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. IL-7 Deficiency Exacerbates Atopic Dermatitis in NC/Nga Mice.
      Title: IL-7 Deficiency Exacerbates Atopic Dermatitis in NC/Nga Mice.
    2. Interleukin-7 aggravates myocardial ischaemia/reperfusion injury by regulating macrophage infiltration and polarization.
      Title: Interleukin-7 aggravates myocardial ischaemia/reperfusion injury by regulating macrophage infiltration and polarization.
    3. The Broad Immunomodulatory Effects of IL-7 and Its Application In Vaccines.
      Title: The Broad Immunomodulatory Effects of IL-7 and Its Application In Vaccines.
    4. Selective dependence on IL-7 for antigen-specific CD8 T cell responses during airway influenza infection.
      Title: Selective dependence on IL-7 for antigen-specific CD8 T cell responses during airway influenza infection.
    5. In vivo availability of the cytokine IL-7 constrains the survival and homeostasis of peripheral iNKT cells.
      Title: In vivo availability of the cytokine IL-7 constrains the survival and homeostasis of peripheral iNKT cells.
    6. Interleukin-7 protects CD8(+) T cells from adenosine-mediated immunosuppression.
      Title: Interleukin-7 protects CD8(+) T cells from adenosine-mediated immunosuppression.
    7. Prosurvival IL-7-Stimulated Weak Strength of mTORC1-S6K Controls T Cell Memory via Transcriptional FOXO1-TCF1-Id3 and Metabolic AMPKalpha1-ULK1-ATG7 Pathways.
      Title: Prosurvival IL-7-Stimulated Weak Strength of mTORC1-S6K Controls T Cell Memory via Transcriptional FOXO1-TCF1-Id3 and Metabolic AMPKα1-ULK1-ATG7 Pathways.
    8. IL-2/IL-7-inducible factors pioneer the path to T cell differentiation in advance of lineage-defining factors.
      Title: IL-2/IL-7-inducible factors pioneer the path to T cell differentiation in advance of lineage-defining factors.
    9. Interleukin-7 protects against bacterial respiratory infection by promoting IL-17A-producing innate T-cell response.
      Title: Interleukin-7 protects against bacterial respiratory infection by promoting IL-17A-producing innate T-cell response.
    10. IL-7 derived from lymph node fibroblastic reticular cells is dispensable for naive T cell homeostasis but crucial for central memory T cell survival.
      Title: IL-7 derived from lymph node fibroblastic reticular cells is dispensable for naive T cell homeostasis but crucial for central memory T cell survival.
    Submit: New GeneRIF Correction See all GeneRIFs (183)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC129342

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cytokine activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cytokine activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cytokine receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables growth factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables interleukin-7 receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of B cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within T cell lineage commitment IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within bone resorption IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cytokine-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of extrinsic apoptotic signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within homeostasis of number of cells within a tissue IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of catalytic activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of organ growth IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of organ growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of B cell differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of B cell proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of B cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of T cell differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of chemokine production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cytokine-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of organ growth IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of organ growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    interleukin-7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001313888.1 → NP_001300817.1  interleukin-7 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an alternate exon near the 5' end compared to variant 1. This difference causes translation initiation at a downstream AUG and results in an isoform (b) with a shorter N-terminus, compared to isoform a.
      Source sequence(s)
      AK040399, AK052452
      Consensus CDS
      CCDS84608.1
      UniProtKB/TrEMBL
      Q3UT18, Q8C9S3
      Related
      ENSMUSP00000141508.2, ENSMUST00000192202.6
      Conserved Domains (1) summary
      cl11602
      Location:1 → 111
      IL7; Interleukin 7/9 family

    2. NM_001313889.1 → NP_001300818.1  interleukin-7 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains an alternate exon near the 5' end and an alternate internal exon compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (c) with a shorter N-terminus, compared to isoform a.
      Source sequence(s)
      AK040399, AK042009, AK052452
      Conserved Domains (1) summary
      cl11602
      Location:1 → 102
      IL7; Interleukin 7/9 family

    3. NM_001313890.1 → NP_001300819.1  interleukin-7 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) contains two alternate exons in place of the first exon compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (b) with a shorter N-terminus, compared to isoform a. Variants 2 and 4 both encode the same isoform (b).
      Source sequence(s)
      AK040399, AK139858
      Consensus CDS
      CCDS84608.1
      UniProtKB/TrEMBL
      Q3UT18, Q8C9S3
      Related
      ENSMUSP00000141827.2, ENSMUST00000194184.6
      Conserved Domains (1) summary
      cl11602
      Location:1 → 111
      IL7; Interleukin 7/9 family

    4. NM_008371.5 → NP_032397.1  interleukin-7 isoform a precursor

      See identical proteins and their annotated locations for NP_032397.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AK040399, AK041307, AK052452
      Consensus CDS
      CCDS50859.1
      UniProtKB/Swiss-Prot
      P10168
      UniProtKB/TrEMBL
      Q544C8, Q8C9S3
      Related
      ENSMUSP00000141845.2, ENSMUST00000194279.6
      Conserved Domains (1) summary
      smart00127
      Location:27 → 152
      IL7; Interleukin-7 and interleukin-9 family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      7637088..7678820 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P10168.1 GenPept UniProtKB/Swiss-Prot:P10168

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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