Dyrk2 dual-specificity tyrosine phosphorylation regulated kinase 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dyrk2provided by MGI
Official Full Name: dual-specificity tyrosine phosphorylation regulated kinase 2provided by MGI
Primary source: MGI:MGI:1330301
See related: Ensembl:ENSMUSG00000028630 AllianceGenome:MGI:1330301
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1810038L18Rik
Summary: Predicted to enable ATP binding activity; metal ion binding activity; and protein kinase activity. Predicted to be involved in several processes, including intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; negative regulation of calcineurin-NFAT signaling cascade; and protein phosphorylation. Predicted to act upstream of or within peptidyl-tyrosine phosphorylation. Part of ribonucleoprotein complex. Is expressed in several structures, including brain; eye; gut gland; hemolymphoid system gland; and reproductive system. Orthologous to human DYRK2 (dual specificity tyrosine phosphorylation regulated kinase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E18 (RPKM 10.4), large intestine adult (RPKM 9.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 D2; 10 66.75 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (118691507..118725144, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (118855602..118889245, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The novel ciliogenesis regulator DYRK2 governs Hedgehog signaling during mouse embryogenesis.
Title: The novel ciliogenesis regulator DYRK2 governs Hedgehog signaling during mouse embryogenesis.
results suggest that DYRK2 is a molecular checkpoint controlling p53- and c-Myc-mediated regulation of survival and self-renewal in CML cells with leukemic-initiating capacity that can be targeted with small molecules.
Title: A KLF4-DYRK2-mediated pathway regulating self-renewal in CML stem cells.
Dyrk2 regulates osteoclast fusion in a cell heterotypic manner.
Title: Dual-specificity tyrosine phosphorylation-regulated kinase 2 regulates osteoclast fusion in a cell heterotypic manner.
DYRK2 regulates tumor progression through modulation of c-Jun and c-Myc
Title: DYRK2 priming phosphorylation of c-Jun and c-Myc modulates cell cycle progression in human cancer cells.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dyrk2 (e-PCR), detects polymorphism
- UniSTS:530946

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	ISO Inferred from Sequence Orthology more info
enables manganese ion binding	ISO Inferred from Sequence Orthology more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine/tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of calcineurin-NFAT signaling cascade	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-serine phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in peptidyl-threonine phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of glycogen biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in smoothened signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info	PubMed
is_active_in cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of ribonucleoprotein complex	IDA Inferred from Direct Assay more info	PubMed
part_of ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: dual specificity tyrosine-phosphorylation-regulated kinase 2

Names: dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2

NP_001014412.1

EC 2.7.12.1

XP_006514109.3

EC 2.7.12.1

XP_011241854.1

EC 2.7.12.1

XP_036011873.1

EC 2.7.12.1

XP_036011874.1

EC 2.7.12.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001014390.2 → NP_001014412.1 dual specificity tyrosine-phosphorylation-regulated kinase 2

See identical proteins and their annotated locations for NP_001014412.1

Status: PROVISIONAL

Source sequence(s)

AC154039

Consensus CDS

CCDS24201.1

UniProtKB/Swiss-Prot

Q5U4C9

Related

ENSMUSP00000004281.9, ENSMUST00000004281.10

Conserved Domains (2) summary

smart00220
Location:220 → 533

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14224
Location:154 → 533

PKc_DYRK2_3; Catalytic domain of the protein kinases, Dual-specificity tYrosine-phosphorylated and -Regulated Kinases 2 and 3

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

118691507..118725144 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011243552.3 → XP_011241854.1 dual specificity tyrosine-phosphorylation-regulated kinase 2 isoform X2

See identical proteins and their annotated locations for XP_011241854.1

Conserved Domains (1) summary

cd14224
Location:81 → 460

PKc_DYRK2_3; Catalytic domain of the protein kinases, Dual-specificity tYrosine-phosphorylated and -Regulated Kinases 2 and 3
XM_036155980.1 → XP_036011873.1 dual specificity tyrosine-phosphorylation-regulated kinase 2 isoform X2

Conserved Domains (1) summary

cd14224
Location:81 → 460

PKc_DYRK2_3; Catalytic domain of the protein kinases, Dual-specificity tYrosine-phosphorylated and -Regulated Kinases 2 and 3
XM_006514046.5 → XP_006514109.3 dual specificity tyrosine-phosphorylation-regulated kinase 2 isoform X1

Conserved Domains (1) summary

cd14224
Location:220 → 599

PKc_DYRK2_3; Catalytic domain of the protein kinases, Dual-specificity tYrosine-phosphorylated and -Regulated Kinases 2 and 3
XM_036155981.1 → XP_036011874.1 dual specificity tyrosine-phosphorylation-regulated kinase 2 isoform X2

Conserved Domains (1) summary

cd14224
Location:81 → 460

PKc_DYRK2_3; Catalytic domain of the protein kinases, Dual-specificity tYrosine-phosphorylated and -Regulated Kinases 2 and 3