Serpinb3a serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Serpinb3aprovided by MGI
Official Full Name: serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3Aprovided by MGI
Primary source: MGI:MGI:3573933
See related: Ensembl:ENSMUSG00000044594 AllianceGenome:MGI:3573933
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Sqn5; Scca2; Serpinb4; 1110001H02Rik; 1110013A16Rik
Summary: Predicted to enable endopeptidase inhibitor activity; protease binding activity; and virus receptor activity. Predicted to be involved in negative regulation of endopeptidase activity. Predicted to be located in cytoplasmic vesicle; extracellular exosome; and nucleus. Predicted to be active in extracellular space. Orthologous to human SERPINB3 (serpin family B member 3) and SERPINB4 (serpin family B member 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in lung adult (RPKM 6.2), stomach adult (RPKM 0.8) and 1 other tissue See more
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Genomic context

Location:: 1 E2.1; 1 50.34 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (106973317..106980033, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (107045587..107052303, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Lysoptosis is an evolutionarily conserved cell death pathway moderated by intracellular serpins.
Title: Lysoptosis is an evolutionarily conserved cell death pathway moderated by intracellular serpins.
Serpinb3a deficiency attenuates barrier dysfunction and the early inflammatory response following cutaneous allergen exposure, supporting a role for Serpinb3a (mice) and SERPINB3/B4 (humans) early in atopic dermatitis.
Title: SERPINB3/B4 contributes to early inflammation and barrier dysfunction in an experimental murine model of atopic dermatitis.
The serum level of SCCA is effective for detecting inverted papilloma (IP), including recurrent IP. In contrast, the SCCA2/SCCA1 ratio is useful for detecting squamous cell carcinoma among other sinonasal diseases.
Title: Squamous cell carcinoma antigen production in nasal inverted papilloma.
data reveal a novel nonredundant role for Serpinb3a in mediating mucus production through regulation of sterile alpha motif pointed domain containing v-ets avian erythroblastosis virus E26 oncogene homolog transcription factor expression
Title: A nonredundant role for mouse Serpinb3a in the induction of mucus production in asthma.
Characerization of the functional properties of Serpinb3c.
Title: Characterization of novel squamous cell carcinoma antigen-related molecules in mice.
SCCA2-like serpins mediate genetic predisposition to skin cancer in a mouse model and in humans.
Title: SCCA2-like serpins mediate genetic predisposition to skin tumors.
SQN-5 employed different reactive centers to neutralize the serine and cysteine proteinases.
Title: The serpin SQN-5 is a dual mechanistic-class inhibitor of serine and cysteine proteinases.
Uteroglobin suppresses SCCA gene expression associated with airway inflammation in asthma
Title: Uteroglobin suppresses SCCA gene expression associated with allergic asthma.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1) 1 citation

General gene information

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Markers

NoName (e-PCR)
- UniSTS:491955

Scca2 (e-PCR), detects polymorphism
- UniSTS:144848

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cysteine-type endopeptidase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables protease binding	ISO Inferred from Sequence Orthology more info
enables serine-type endopeptidase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables virus receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in negative regulation of endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in extracellular exosome	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: serine peptidase inhibitor, clade B, member 3A

Names: serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 3A; squamous cell carcinoma antigen 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009126.3 → NP_033152.3 serine peptidase inhibitor, clade B, member 3A

See identical proteins and their annotated locations for NP_033152.3

Status: VALIDATED

Source sequence(s)

AC125111, BB699605, BC063756

Consensus CDS

CCDS15214.1

UniProtKB/TrEMBL

G3X9V8, Q8BG86

Related

ENSMUSP00000108337.2, ENSMUST00000112717.3

Conserved Domains (1) summary

cl00137
Location:5 → 387

SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...