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    Bicd1 BICD cargo adaptor 1 [ Mus musculus (house mouse) ]

    Gene ID: 12121, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Bicd1provided by MGI
    Official Full Name
    BICD cargo adaptor 1provided by MGI
    Primary source
    MGI:MGI:1101760
    See related
    Ensembl:ENSMUSG00000003452 AllianceGenome:MGI:1101760
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    bic-D 1; B830009D06Rik
    Summary
    Enables proteinase activated receptor binding activity. Involved in several processes, including negative regulation of phospholipase C activity; regulation of signal transduction; and stress granule assembly. Predicted to be located in several cellular components, including centrosome; perinuclear region of cytoplasm; and trans-Golgi network. Predicted to be active in Golgi apparatus and cytosol. Predicted to colocalize with cytoplasmic microtubule. Is expressed in several structures, including gut; heart; nervous system; reproductive system; and sensory organ. Orthologous to human BICD1 (BICD cargo adaptor 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in cerebellum adult (RPKM 3.4), CNS E18 (RPKM 3.2) and 17 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Bicd1 in Genome Data Viewer
    Location:
    6 G3; 6 78.94 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (149310322..149464827)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (149408824..149563329)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene adaptor-related protein complex AP-1, sigma 3 pseudogene Neighboring gene MRT4, mRNA turnover 4, homolog pseudogene Neighboring gene predicted gene 15785 Neighboring gene STARR-seq mESC enhancer starr_17873 Neighboring gene STARR-seq mESC enhancer starr_17874 Neighboring gene STARR-seq mESC enhancer starr_17875 Neighboring gene predicted gene, 38931 Neighboring gene predicted gene, 21814

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Structural basis for cargo binding and autoinhibition of Bicaudal-D1 by a parallel coiled-coil with homotypic registry. Terawaki S, et al. Biochem Biophys Res Commun, 2015 May 1. PMID 25796327
    2. Bicaudal-D1 regulates the intracellular sorting and signalling of neurotrophin receptors. Terenzio M, et al. EMBO J, 2014 Jul 17. PMID 24920579, Free PMC Article
    3. A human homologue (BICD1) of the Drosophila bicaudal-D gene. Baens M, et al. Genomics, 1997 Nov 1. PMID 9367685
    4. A novel protease-activated receptor-1 interactor, Bicaudal D1, regulates G protein signaling and internalization. Swift S, et al. J Biol Chem, 2010 Apr 9. PMID 20164183, Free PMC Article
    5. Isolation and regional assignment of human chromosome 12p cDNAs. Baens M, et al. Genomics, 1995 Sep 1. PMID 8530100

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PTPN23 binds the dynein adaptor BICD1 and is required for endocytic sorting of neurotrophin receptors.
      Title: PTPN23 binds the dynein adaptor BICD1 and is required for endocytic sorting of neurotrophin receptors.
    2. findings suggest a molecular basis for cargo recognition and autoinhibition of BICD proteins during dynein-dependent intracellular retrograde transport
      Title: Structural basis for cargo binding and autoinhibition of Bicaudal-D1 by a parallel coiled-coil with homotypic registry.
    3. BICD1 regulates neurotrophin signalling by modulating the endosomal sorting of internalised ligand-activated receptors.
      Title: Bicaudal-D1 regulates the intracellular sorting and signalling of neurotrophin receptors.
    4. Impairment of retrograde transport by knockdown of DHC1 or BicD1 inhibits stress-granule formation and P-body growth upon stress.
      Title: Dynein and kinesin regulate stress-granule and P-body dynamics.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (2) 
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA4125

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cytoskeletal anchor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cytoskeletal anchor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables dynactin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dynactin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables dynein complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dynein complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables dynein intermediate chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dynein intermediate chain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables proteinase activated receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables proteinase activated receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in microtubule anchoring at microtubule organizing center IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule anchoring at microtubule organizing center IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in minus-end-directed organelle transport along microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of phospholipase C activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein localization to centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of receptor-mediated endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of receptor-mediated endocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of microtubule cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of proteinase activated receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in stress granule assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in viral process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    colocalizes_with Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    colocalizes_with cytoplasmic microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in secretory vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein bicaudal D homolog 1
    Names
    bicaudal D homolog 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001112796.2 → NP_001106267.1  protein bicaudal D homolog 1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) lacks an alternate exon in the 3' coding region and differs in the 3' UTR, compared to variant 2. It encodes isoform 1, which is shorter and has a distinct C-terminus, compared to isoform 2.
      Source sequence(s)
      AC164090, AK043650, AK051379, AK082523
      Consensus CDS
      CCDS51962.1
      UniProtKB/TrEMBL
      Q5DTM3
      Related
      ENSMUSP00000107138.3, ENSMUST00000111513.9
      Conserved Domains (1) summary
      pfam09730
      Location:74 → 799
      BicD; Microtubule-associated protein Bicaudal-D

    2. NM_009753.4 → NP_033883.2  protein bicaudal D homolog 1 isoform 2

      See identical proteins and their annotated locations for NP_033883.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents the longer transcript and encodes the longer isoform (2).
      Source sequence(s)
      AC164090, AK043650, AK051379, AK082523
      Consensus CDS
      CCDS39723.1
      UniProtKB/Swiss-Prot
      O55206, Q8BQ18, Q8BR07, Q8BRR8, Q8C4D3, Q8CAK6, Q8R2J4, Q8R2J5, Q8R2J6, Q91YP7
      UniProtKB/TrEMBL
      Q5DTM3
      Related
      ENSMUSP00000084039.5, ENSMUST00000086829.11
      Conserved Domains (1) summary
      pfam09730
      Location:74 → 799
      BicD; Microtubule-associated protein Bicaudal-D

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      149310322..149464827
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006507014.4 → XP_006507077.1  protein bicaudal D homolog 1 isoform X1

      See identical proteins and their annotated locations for XP_006507077.1

      UniProtKB/TrEMBL
      Q5DTM3
      Conserved Domains (1) summary
      pfam09730
      Location:74 → 799
      BicD; Microtubule-associated protein Bicaudal-D

    2. XM_006507017.4 → XP_006507080.1  protein bicaudal D homolog 1 isoform X5

      See identical proteins and their annotated locations for XP_006507080.1

      UniProtKB/TrEMBL
      Q5DTM3
      Conserved Domains (1) summary
      pfam09730
      Location:74 → 799
      BicD; Microtubule-associated protein Bicaudal-D

    3. XM_006507015.4 → XP_006507078.1  protein bicaudal D homolog 1 isoform X2

      See identical proteins and their annotated locations for XP_006507078.1

      UniProtKB/TrEMBL
      B2KG46, Q5DTM3
      Related
      ENSMUSP00000003544.8, ENSMUST00000003544.14
      Conserved Domains (1) summary
      pfam09730
      Location:74 → 799
      BicD; Microtubule-associated protein Bicaudal-D

    4. XM_006507016.4 → XP_006507079.1  protein bicaudal D homolog 1 isoform X3

      See identical proteins and their annotated locations for XP_006507079.1

      UniProtKB/TrEMBL
      Q5DTM3
      Conserved Domains (1) summary
      pfam09730
      Location:74 → 799
      BicD; Microtubule-associated protein Bicaudal-D

    5. XM_006507018.4 → XP_006507081.1  protein bicaudal D homolog 1 isoform X6

      See identical proteins and their annotated locations for XP_006507081.1

      UniProtKB/TrEMBL
      Q5DTM3
      Conserved Domains (1) summary
      pfam09730
      Location:74 → 799
      BicD; Microtubule-associated protein Bicaudal-D

    6. XM_036165765.1 → XP_036021658.1  protein bicaudal D homolog 1 isoform X8

      UniProtKB/TrEMBL
      Q5DTM3
      Conserved Domains (1) summary
      pfam09730
      Location:74 → 799
      BicD; Microtubule-associated protein Bicaudal-D

    7. XM_030255123.1 → XP_030110983.1  protein bicaudal D homolog 1 isoform X7

      UniProtKB/TrEMBL
      Q5DTM3
      Conserved Domains (1) summary
      pfam09730
      Location:74 → 799
      BicD; Microtubule-associated protein Bicaudal-D

    8. XM_006507023.4 → XP_006507086.1  protein bicaudal D homolog 1 isoform X11

      See identical proteins and their annotated locations for XP_006507086.1

      UniProtKB/TrEMBL
      Q5DTM3
      Conserved Domains (1) summary
      pfam09730
      Location:74 → 799
      BicD; Microtubule-associated protein Bicaudal-D

    9. XM_006507020.4 → XP_006507083.1  protein bicaudal D homolog 1 isoform X10

      See identical proteins and their annotated locations for XP_006507083.1

      UniProtKB/TrEMBL
      Q5DTM3
      Conserved Domains (1) summary
      pfam09730
      Location:74 → 799
      BicD; Microtubule-associated protein Bicaudal-D

    10. XM_006507019.5 → XP_006507082.1  protein bicaudal D homolog 1 isoform X9

      See identical proteins and their annotated locations for XP_006507082.1

      UniProtKB/TrEMBL
      Q5DTM3
      Conserved Domains (1) summary
      pfam09730
      Location:74 → 799
      BicD; Microtubule-associated protein Bicaudal-D

    11. XM_036165764.1 → XP_036021657.1  protein bicaudal D homolog 1 isoform X4

      UniProtKB/TrEMBL
      Q5DTM3
      Conserved Domains (1) summary
      pfam09730
      Location:74 → 799
      BicD; Microtubule-associated protein Bicaudal-D

    12. XM_036165766.1 → XP_036021659.1  protein bicaudal D homolog 1 isoform X12

      UniProtKB/TrEMBL
      Q5DTM3
      Conserved Domains (1) summary
      pfam09730
      Location:74 → 799
      BicD; Microtubule-associated protein Bicaudal-D

    13. XM_006507024.4 → XP_006507087.1  protein bicaudal D homolog 1 isoform X13

      See identical proteins and their annotated locations for XP_006507087.1

      UniProtKB/TrEMBL
      G3UXK5, Q5DTM3
      Related
      ENSMUSP00000133727.2, ENSMUST00000173408.8
      Conserved Domains (1) summary
      pfam09730
      Location:74 → 799
      BicD; Microtubule-associated protein Bicaudal-D

    RNA

    1. XR_003956156.1 RNA Sequence

    2. XR_004942913.1 RNA Sequence

    3. XR_869604.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BR07.2 GenPept UniProtKB/Swiss-Prot:Q8BR07

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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