Lim2 lens intrinsic membrane protein 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lim2provided by MGI
Official Full Name: lens intrinsic membrane protein 2provided by MGI
Primary source: MGI:MGI:104698
See related: Ensembl:ENSMUSG00000118560 AllianceGenome:MGI:104698
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: To3; MP17; MP18; MP19; MP20; 4833403J20
Summary: Predicted to be a structural constituent of eye lens. Acts upstream of or within lens development in camera-type eye. Predicted to be located in vesicle. Predicted to be active in plasma membrane. Is expressed in embryo; head; inter-parietal bone primordium; and lens. Used to study cataract and cataract 19 multiple types. Human ortholog(s) of this gene implicated in cataract and cataract 19 multiple types. Orthologous to several human genes including LIM2 (lens intrinsic membrane protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 7 B3; 7 28.25 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (43079523..43085420)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (43430099..43435996)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A novel missense mutation in the Lim2 gene affects lens development in a semidominant manner. Since homozygous mutants develop congenital lens opacities, this mouse line can be used as a model for inherited cataract formation in humans.
Title: Microphakia and congenital cataract formation in a novel Lim2(C51R) mutant mouse.
Data show that the calcium- and integrin-binding protein CIB as an LMO3-binding protein, which binds via the second LIM domain (LIM2) of LMO3.
Title: The oncoprotein LMO3 interacts with calcium- and integrin-binding protein CIB.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1) 1 citation
Chemically induced (ENU) (2) 1 citation
Endonuclease-mediated (1)

General gene information

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Markers

GDB:373986 (e-PCR)
- UniSTS:156932

NoName (e-PCR)
- UniSTS:482181

NoName (e-PCR)
- UniSTS:492968

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables structural constituent of eye lens	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within camera-type eye development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lens development in camera-type eye	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in bicellular tight junction	TAS Traceable Author Statement more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: lens fiber membrane intrinsic protein

Names: total opacity 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.