U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Lax1 lymphocyte transmembrane adaptor 1 [ Mus musculus (house mouse) ]

    Gene ID: 240754, updated on 21-Apr-2024

    Summary

    Official Symbol
    Lax1provided by MGI
    Official Full Name
    lymphocyte transmembrane adaptor 1provided by MGI
    Primary source
    MGI:MGI:2443362
    See related
    Ensembl:ENSMUSG00000051998 AllianceGenome:MGI:2443362
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A530029E09; E430019B13Rik
    Summary
    Predicted to enable SH2 domain binding activity and protein kinase binding activity. Acts upstream of or within antigen receptor-mediated signaling pathway and lymphocyte activation. Predicted to be located in Golgi apparatus and cytosol. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Orthologous to human LAX1 (lymphocyte transmembrane adaptor 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in spleen adult (RPKM 14.6), thymus adult (RPKM 5.7) and 7 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Location:
    1 E4; 1 57.95 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (133606767..133620760, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (133679017..133693022, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_02294 Neighboring gene small nuclear ribonucleoprotein E Neighboring gene predicted gene, 53475 Neighboring gene zinc finger CCCH type containing 11A Neighboring gene zinc finger, BED type containing 6 Neighboring gene STARR-seq mESC enhancer starr_02296 Neighboring gene STARR-seq mESC enhancer starr_02297 Neighboring gene STARR-seq mESC enhancer starr_02298 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:135586656-135586812 Neighboring gene STARR-seq mESC enhancer starr_02299 Neighboring gene ATPase, Ca++ transporting, plasma membrane 4 Neighboring gene STARR-seq mESC enhancer starr_02301 Neighboring gene microRNA 6903 Neighboring gene STARR-seq mESC enhancer starr_02302 Neighboring gene predicted gene, 53476

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (3) 

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SH2 domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in B cell activation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in antigen receptor-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within antigen receptor-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in immune response ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within immunoglobulin production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lymphocyte activation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within lymphocyte activation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of MAP kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of T cell activation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of T cell activation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of lymphocyte activation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    lymphocyte transmembrane adapter 1
    Names
    linker for activation of X cells
    membrane-associated adapter protein LAX

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159649.1NP_001153121.1  lymphocyte transmembrane adapter 1

      See identical proteins and their annotated locations for NP_001153121.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC124338, AY090785
      Consensus CDS
      CCDS35711.1
      UniProtKB/Swiss-Prot
      Q8BHB3, Q8BS18, Q8CGV1
      Related
      ENSMUSP00000131126.2, ENSMUST00000169295.8
      Conserved Domains (1) summary
      pfam15681
      Location:28356
      LAX; Lymphocyte activation family X
    2. NM_172842.3NP_766430.3  lymphocyte transmembrane adapter 1

      See identical proteins and their annotated locations for NP_766430.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC124338, AY090785
      Consensus CDS
      CCDS35711.1
      UniProtKB/Swiss-Prot
      Q8BHB3, Q8BS18, Q8CGV1
      Conserved Domains (1) summary
      pfam15681
      Location:28356
      LAX; Lymphocyte activation family X

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      133606767..133620760 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006529557.5XP_006529620.1  lymphocyte transmembrane adapter 1 isoform X1

      See identical proteins and their annotated locations for XP_006529620.1

      UniProtKB/Swiss-Prot
      Q8BHB3, Q8BS18, Q8CGV1
      Conserved Domains (1) summary
      pfam15681
      Location:28356
      LAX; Lymphocyte activation family X