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    Sccpdh saccharopine dehydrogenase (putative) [ Mus musculus (house mouse) ]

    Gene ID: 109232, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Sccpdhprovided by MGI
    Official Full Name
    saccharopine dehydrogenase (putative)provided by MGI
    Primary source
    MGI:MGI:1924486
    See related
    Ensembl:ENSMUSG00000038936 AllianceGenome:MGI:1924486
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C330023F11Rik
    Summary
    Predicted to enable oxidoreductase activity. Predicted to be involved in glycolipid biosynthetic process. Located in mitochondrion. Is expressed in brain. Orthologous to human SCCPDH (saccharopine dehydrogenase (putative)). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in testis adult (RPKM 84.7), cerebellum adult (RPKM 29.1) and 18 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Sccpdh in Genome Data Viewer
    Location:
    1 H4; 1 83.62 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (179495796..179514754)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (179667749..179687189)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2590 Neighboring gene STARR-positive B cell enhancer ABC_E4399 Neighboring gene transcription factor B2, mitochondrial Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:181508880-181509063 Neighboring gene consortin, connexin sorting protein Neighboring gene STARR-seq mESC enhancer starr_03181 Neighboring gene STARR-seq mESC enhancer starr_03183 Neighboring gene kinesin family member 28 Neighboring gene AT hook containing transcription factor 1 Neighboring gene STARR-positive B cell enhancer ABC_E3340 Neighboring gene STARR-positive B cell enhancer ABC_E5865 Neighboring gene STARR-seq mESC enhancer starr_03185 Neighboring gene predicted gene, 31668 Neighboring gene STARR-seq mESC enhancer starr_03186

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The ATG5 interactome links clathrin-mediated vesicular trafficking with the autophagosome assembly machinery. Baines K, et al. Autophagy Rep, 2022. PMID 35449600, Free PMC Article
    2. An Interaction Landscape of Ubiquitin Signaling. Zhang X, et al. Mol Cell, 2017 Mar 2. PMID 28190767
    3. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
    4. A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Thompson CL, et al. Neuron, 2014 Jul 16. PMID 24952961, Free PMC Article
    5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in glycolipid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in lipid droplet IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lipid droplet ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    saccharopine dehydrogenase-like oxidoreductase
    Names
    probable saccharopine dehydrogenase
    NP_001404405.1
    NP_001404406.1
    NP_848768.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001417476.1 → NP_001404405.1  saccharopine dehydrogenase-like oxidoreductase isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC113977

    2. NM_001417477.1 → NP_001404406.1  saccharopine dehydrogenase-like oxidoreductase isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC113977

    3. NM_178653.4 → NP_848768.1  saccharopine dehydrogenase-like oxidoreductase isforom 1

      See identical proteins and their annotated locations for NP_848768.1

      Status: VALIDATED

      Source sequence(s)
      AC113977
      Consensus CDS
      CCDS15563.1
      UniProtKB/Swiss-Prot
      Q3TMB9, Q8R127
      Related
      ENSMUSP00000040956.4, ENSMUST00000040538.10
      Conserved Domains (2) summary
      COG3268
      Location:1 → 421
      COG3268; Uncharacterized conserved protein, related to short-chain dehydrogenases [Function unknown]
      pfam03435
      Location:10 → 149
      Sacchrp_dh_NADP; Saccharopine dehydrogenase NADP binding domain

    RNA

    1. NR_184455.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC113977
      Related
      ENSMUST00000134287.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      179495796..179514754
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R127.1 GenPept UniProtKB/Swiss-Prot:Q8R127

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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