Zfp354c zinc finger protein 354C [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zfp354cprovided by MGI
Official Full Name: zinc finger protein 354Cprovided by MGI
Primary source: MGI:MGI:1353621
See related: Ensembl:ENSMUSG00000044807 AllianceGenome:MGI:1353621
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: AJ18; Kid3; Tcf17l2; Znf354c; mKIAA4218; 5330421P20Rik
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including eye; genitourinary system; heart; lung; and spleen. Orthologous to human ZNF354C (zinc finger protein 354C). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in CNS E18 (RPKM 9.9), limb E14.5 (RPKM 9.5) and 11 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B1.3; 11 30.93 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (50701912..50718558, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (50811085..50827731, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

expression of AJ18 is consistent with its perceived role as a transcriptional factor that regulates developmental processes downstream of BMP-7 (AJ18 protein).
Title: Temporal and spatial expression of a novel zinc finger transcription factor, AJ18, in developing murine skeletal tissues.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in negative regulation of sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: zinc finger protein 354C

Names: kidney, ischemia, and developmentally-regulated protein 3; transcription factor 17-like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013922.4 → NP_038950.3 zinc finger protein 354C

See identical proteins and their annotated locations for NP_038950.3

Status: VALIDATED

Source sequence(s)

AL627215, BC079908

Consensus CDS

CCDS24637.1

UniProtKB/Swiss-Prot

Q3UKS9, Q571J5, Q8C365, Q9JLD3

Related

ENSMUSP00000104763.3, ENSMUST00000109135.9

Conserved Domains (5) summary

smart00349
Location:14 → 74

KRAB; krueppel associated box

COG5048
Location:204 → 543

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:248 → 268

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam01352
Location:14 → 53

KRAB; KRAB box

pfam13465
Location:456 → 481

zf-H2C2_2; Zinc-finger double domain