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    Morf4l2 mortality factor 4 like 2 [ Mus musculus (house mouse) ]

    Gene ID: 56397, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Morf4l2provided by MGI
    Official Full Name
    mortality factor 4 like 2provided by MGI
    Primary source
    MGI:MGI:1927167
    See related
    Ensembl:ENSMUSG00000031422 AllianceGenome:MGI:1927167
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mrgx; Sid393p; mKIAA0026; 2410017O14Rik
    Summary
    Predicted to be involved in heterochromatin assembly and histone modification. Predicted to act upstream of or within DNA repair and regulation of growth. Predicted to be located in nucleolus; nucleoplasm; and plasma membrane. Predicted to be part of NuA4 histone acetyltransferase complex. Is expressed in genitourinary system and retina. Orthologous to human MORF4L2 (mortality factor 4 like 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in placenta adult (RPKM 441.2), CNS E11.5 (RPKM 149.5) and 12 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Morf4l2 in Genome Data Viewer
    Location:
    X F1; X 59.1 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (135633691..135644435, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (136732942..136743686, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene acyl-protein thioesterase 1 pseudogene Neighboring gene predicted gene, 39536 Neighboring gene transcription elongation factor A (SII)-like 1 Neighboring gene STARR-seq mESC enhancer starr_47978 Neighboring gene STARR-positive B cell enhancer ABC_E3262 Neighboring gene STARR-positive B cell enhancer ABC_E11056 Neighboring gene cDNA sequence BC065397 Neighboring gene glycine receptor, alpha 4 subunit Neighboring gene predicted gene, 54085 Neighboring gene STARR-seq mESC enhancer starr_47979 Neighboring gene proteolipid protein (myelin) 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. MrgX is not essential for cell growth and development in the mouse. Tominaga K, et al. Mol Cell Biol, 2005 Jun. PMID 15923606, Free PMC Article
    2. Conservation of the MORF4 related gene family: identification of a new chromo domain subfamily and novel protein motif. Bertram MJ, et al. Gene, 2001 Mar 21. PMID 11290425
    3. HSF2BP Interacts with a Conserved Domain of BRCA2 and Is Required for Mouse Spermatogenesis. Brandsma I, et al. Cell Rep, 2019 Jun 25. PMID 31242413
    4. Hdac6 regulates Tip60-p400 function in stem cells. Chen PB, et al. Elife, 2013 Dec 3. PMID 24302573, Free PMC Article
    5. The TIP60 Complex Regulates Bivalent Chromatin Recognition by 53BP1 through Direct H4K20me Binding and H2AK15 Acetylation. Jacquet K, et al. Mol Cell, 2016 May 5. PMID 27153538, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2)  1 citation
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of DNA-templated transcription NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of apoptotic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of double-strand break repair NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of NuA4 histone acetyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of NuA4 histone acetyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of nucleosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    mortality factor 4-like protein 2
    Names
    MORF-related gene X protein
    sid 393
    transcription factor-like protein Mrgx

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001168225.1 → NP_001161697.1  mortality factor 4-like protein 2

      See identical proteins and their annotated locations for NP_001161697.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 through 7 encode the same protein.
      Source sequence(s)
      AK160012, AL671887, BC075653
      Consensus CDS
      CCDS30422.1
      UniProtKB/Swiss-Prot
      A2AEB2, Q3UL62, Q6DIB1, Q6ZQK7, Q8C201, Q8C6C2, Q9R0Q4
      UniProtKB/TrEMBL
      Q3TME1, Q3U6G8
      Related
      ENSMUSP00000126363.2, ENSMUST00000166930.8
      Conserved Domains (2) summary
      PLN02967
      Location:1 → 150
      PLN02967; kinase
      pfam05712
      Location:110 → 276
      MRG

    2. NM_001168226.1 → NP_001161698.1  mortality factor 4-like protein 2

      See identical proteins and their annotated locations for NP_001161698.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 through 7 encode the same protein.
      Source sequence(s)
      AK160012, AL671887, BC075653, BY141735
      Consensus CDS
      CCDS30422.1
      UniProtKB/Swiss-Prot
      A2AEB2, Q3UL62, Q6DIB1, Q6ZQK7, Q8C201, Q8C6C2, Q9R0Q4
      UniProtKB/TrEMBL
      Q3TME1, Q3U6G8
      Related
      ENSMUSP00000108722.4, ENSMUST00000080411.13
      Conserved Domains (2) summary
      PLN02967
      Location:1 → 150
      PLN02967; kinase
      pfam05712
      Location:110 → 276
      MRG

    3. NM_001168227.1 → NP_001161699.1  mortality factor 4-like protein 2

      See identical proteins and their annotated locations for NP_001161699.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1 through 7 encode the same protein.
      Source sequence(s)
      AK160012, AL671887, BC075653
      Consensus CDS
      CCDS30422.1
      UniProtKB/Swiss-Prot
      A2AEB2, Q3UL62, Q6DIB1, Q6ZQK7, Q8C201, Q8C6C2, Q9R0Q4
      UniProtKB/TrEMBL
      Q3TME1, Q3U6G8
      Related
      ENSMUSP00000129774.2, ENSMUST00000164609.8
      Conserved Domains (2) summary
      PLN02967
      Location:1 → 150
      PLN02967; kinase
      pfam05712
      Location:110 → 276
      MRG

    4. NM_001168228.1 → NP_001161700.1  mortality factor 4-like protein 2

      See identical proteins and their annotated locations for NP_001161700.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1 through 7 encode the same protein.
      Source sequence(s)
      AK161610, AL671887, BC075653
      Consensus CDS
      CCDS30422.1
      UniProtKB/Swiss-Prot
      A2AEB2, Q3UL62, Q6DIB1, Q6ZQK7, Q8C201, Q8C6C2, Q9R0Q4
      UniProtKB/TrEMBL
      Q3TME1, Q3U6G8
      Related
      ENSMUSP00000108720.2, ENSMUST00000113097.8
      Conserved Domains (2) summary
      PLN02967
      Location:1 → 150
      PLN02967; kinase
      pfam05712
      Location:110 → 276
      MRG

    5. NM_001168229.1 → NP_001161701.1  mortality factor 4-like protein 2

      See identical proteins and their annotated locations for NP_001161701.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Variants 1 through 7 encode the same protein.
      Source sequence(s)
      AK160012, AL671887, BC075653, BY141735
      Consensus CDS
      CCDS30422.1
      UniProtKB/Swiss-Prot
      A2AEB2, Q3UL62, Q6DIB1, Q6ZQK7, Q8C201, Q8C6C2, Q9R0Q4
      UniProtKB/TrEMBL
      Q3TME1, Q3U6G8
      Related
      ENSMUSP00000132643.2, ENSMUST00000169418.8
      Conserved Domains (2) summary
      PLN02967
      Location:1 → 150
      PLN02967; kinase
      pfam05712
      Location:110 → 276
      MRG

    6. NM_001168230.1 → NP_001161702.1  mortality factor 4-like protein 2

      See identical proteins and their annotated locations for NP_001161702.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 1. Variants 1 through 7 encode the same protein.
      Source sequence(s)
      AK161610, AL671887, BC075653
      Consensus CDS
      CCDS30422.1
      UniProtKB/Swiss-Prot
      A2AEB2, Q3UL62, Q6DIB1, Q6ZQK7, Q8C201, Q8C6C2, Q9R0Q4
      UniProtKB/TrEMBL
      Q3TME1, Q3U6G8
      Related
      ENSMUSP00000131909.2, ENSMUST00000166478.8
      Conserved Domains (2) summary
      PLN02967
      Location:1 → 150
      PLN02967; kinase
      pfam05712
      Location:110 → 276
      MRG

    7. NM_019768.4 → NP_062742.4  mortality factor 4-like protein 2

      See identical proteins and their annotated locations for NP_062742.4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1 through 7 encode the same protein.
      Source sequence(s)
      AK161610, BC075653
      Consensus CDS
      CCDS30422.1
      UniProtKB/Swiss-Prot
      A2AEB2, Q3UL62, Q6DIB1, Q6ZQK7, Q8C201, Q8C6C2, Q9R0Q4
      UniProtKB/TrEMBL
      Q3TME1, Q3U6G8
      Related
      ENSMUSP00000033797.7, ENSMUST00000033797.13
      Conserved Domains (2) summary
      PLN02967
      Location:1 → 150
      PLN02967; kinase
      pfam05712
      Location:110 → 276
      MRG

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      135633691..135644435 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006528584.3 → XP_006528647.1  mortality factor 4-like protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006528647.1

      UniProtKB/Swiss-Prot
      A2AEB2, Q3UL62, Q6DIB1, Q6ZQK7, Q8C201, Q8C6C2, Q9R0Q4
      UniProtKB/TrEMBL
      Q3TME1, Q3U6G8
      Conserved Domains (2) summary
      PLN02967
      Location:1 → 150
      PLN02967; kinase
      pfam05712
      Location:110 → 276
      MRG
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9R0Q4.1 GenPept UniProtKB/Swiss-Prot:Q9R0Q4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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