Mboat4 membrane bound O-acyltransferase domain containing 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mboat4provided by MGI
Official Full Name: membrane bound O-acyltransferase domain containing 4provided by MGI
Primary source: MGI:MGI:2685017
See related: Ensembl:ENSMUSG00000071113 AllianceGenome:MGI:2685017
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: GOAT; Gm171
Summary: Enables serine O-acyltransferase activity. Involved in peptidyl-serine octanoylation. Located in endoplasmic reticulum. Is integral component of endoplasmic reticulum membrane. Is expressed in prostate gland and testis. Orthologous to human MBOAT4 (membrane bound O-acyltransferase domain containing 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 8 A4; 8 20.9 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (34575032..34592336)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (34106712..34125185)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ghrelin-O-acyltransferase (GOAT) acylates ghrelin in the hippocampus.
Title: Ghrelin-O-acyltransferase (GOAT) acylates ghrelin in the hippocampus.
Unacylated-Ghrelin Impairs Hippocampal Neurogenesis and Memory in Mice and Is Altered in Parkinson's Dementia in Humans.
Title: Unacylated-Ghrelin Impairs Hippocampal Neurogenesis and Memory in Mice and Is Altered in Parkinson's Dementia in Humans.
In Search of Small Molecules That Selectively Inhibit MBOAT4.
Title: In Search of Small Molecules That Selectively Inhibit MBOAT4.
Knockdown of ghrelin-O-acyltransferase attenuates colitis through the modulation of inflammatory factors and tight junction proteins in the intestinal epithelium.
Title: Knockdown of ghrelin-O-acyltransferase attenuates colitis through the modulation of inflammatory factors and tight junction proteins in the intestinal epithelium.
Study demonstrated that ETV5 could transactivate GOAT promoter region and increase its expression, leading to subsequent increase in the production of acyl ghrelin.
Title: ETV5 regulates GOAT/ghrelin system in an mTORC1-dependent manner.
Thus, the adipogenic action of exogenous unacylated ghrelin in tibial marrow is dependent upon acylation by GOAT and activation of GHS-R1a.
Title: Unacylated ghrelin promotes adipogenesis in rodent bone marrow via ghrelin O-acyl transferase and GHS-R(1a) activity: evidence for target cell-induced acylation.
the effect of GOAT on gastric acid secretion and expression of ghrelin in vitro, were investigated.
Title: The effect of ghrelin O-acyltransferase inhibitor on gastric H(+)-K(+)-ATPase activity and GOAT/ghrelin system in gastric mucosal cells in vitro.
Gene browse revealed QTL for body weight/size, genes involved in immune system, and two main protein-coding genes involved in the Glucose homeostasis, Mboat4 and Leprotl1. Heritability and coefficient of genetic variance (CVg) were 0.49 and 0.31 for females, while for males, these values 0.34 and 0.22, respectively.
Title: Glucose tolerance female-specific QTL mapped in collaborative cross mice.
GOAT immunoreactivity is aggregated at the base of the dentate granule cell layer in wild-type mice. This was not affected by the pharmacological inhibition of GHSR1a or the metabolic state-dependent fluctuation of systemic ghrelin levels. But it was absent in the GHSR1a knockout mouse hippocampus, implying that the expression of GHSR1a may be a prerequisite for the production of GOAT.
Title: Endogenous ghrelin-O-acyltransferase (GOAT) acylates local ghrelin in the hippocampus.
Both ghrelin and GOAT are localized primarily in the red pulp of the spleen. Importantly, in the thymus, ghrelin was predominantly localized to the medulla, whereas GOAT was found in the cortex, implying differing roles in T cell development. Both regulates obesity-induced inflammation.
Title: The Ghrelin/GOAT System Regulates Obesity-Induced Inflammation in Male Mice.

Submit: New GeneRIF Correction See all GeneRIFs (31)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation
Targeted (6) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables acyltransferase activity, transferring groups other than amino-acyl groups	IDA Inferred from Direct Assay more info	PubMed
enables acyltransferase activity, transferring groups other than amino-acyl groups	ISO Inferred from Sequence Orthology more info
enables serine O-acyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine O-acyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables serine O-acyltransferase activity	ISO Inferred from Sequence Orthology more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in lipid modification	IBA Inferred from Biological aspect of Ancestor more info
involved_in peptidyl-serine octanoylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in peptidyl-serine octanoylation	IDA Inferred from Direct Assay more info	PubMed
involved_in peptidyl-serine octanoylation	ISO Inferred from Sequence Orthology more info
involved_in protein acylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein decanoylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein octanoylation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ghrelin O-acyltransferase

Names: O-acyltransferase domain-containing protein 4; membrane-bound O-acyltransferase domain-containing protein 4

NP_001119786.1

EC 2.3.1.-

NP_001398667.1

EC 2.3.1.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.