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    Tut1 terminal uridylyl transferase 1, U6 snRNA-specific [ Mus musculus (house mouse) ]

    Gene ID: 70044, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Tut1provided by MGI
    Official Full Name
    terminal uridylyl transferase 1, U6 snRNA-specificprovided by MGI
    Primary source
    MGI:MGI:1917294
    See related
    Ensembl:ENSMUSG00000071645 AllianceGenome:MGI:1917294
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PAPD2; Rbm21; Tent1; TUTase6; star-PAP; U6-TUTase; 2700038E08Rik
    Summary
    Predicted to enable RNA binding activity; enzyme binding activity; and nucleotidyltransferase activity. Predicted to be involved in U6 snRNA 3'-end processing; mRNA polyadenylation; and pre-mRNA cleavage required for polyadenylation. Predicted to act upstream of or within mRNA processing. Predicted to be located in cytosol; nucleolus; and nucleoplasm. Predicted to be part of mRNA cleavage and polyadenylation specificity factor complex. Predicted to be active in nuclear speck. Is expressed in central nervous system; genitourinary system; and sensory organ. Orthologous to human TUT1 (terminal uridylyl transferase 1, U6 snRNA-specific). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 15.7), thymus adult (RPKM 11.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    19 A; 19 6.04 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (8931199..8943572)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (8953832..8966210)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5684 Neighboring gene echinoderm microtubule associated protein like 3 Neighboring gene rod outer segment membrane protein 1 Neighboring gene predicted gene 10353 Neighboring gene STARR-positive B cell enhancer ABC_E11018 Neighboring gene metastasis-associated gene family, member 2 Neighboring gene STARR-positive B cell enhancer ABC_E3241 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:9041491-9041707 Neighboring gene eukaryotic translation elongation factor 1 gamma Neighboring gene STARR-positive B cell enhancer ABC_E3242 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:9072131-9072314 Neighboring gene AHNAK nucleoprotein Neighboring gene STARR-positive B cell enhancer ABC_E5685

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Primordial dwarfism gene maintains Lin28 expression to safeguard embryonic stem cells from premature differentiation. Dai Q, et al. Cell Rep, 2014 May 8. PMID 24768001
    2. LARP7-Mediated U6 snRNA Modification Ensures Splicing Fidelity and Spermatogenesis in Mice. Wang X, et al. Mol Cell, 2020 Mar 5. PMID 32017896
    3. USP15 Deubiquitinates TUT1 Associated with RNA Metabolism and Maintains Cerebellar Homeostasis. Kim J, et al. Mol Cell Biol, 2020 Oct 13. PMID 32839293, Free PMC Article
    4. A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain. McKee AE, et al. BMC Dev Biol, 2005 Jul 20. PMID 16033648, Free PMC Article
    5. A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract. Wiese CB, et al. Front Neurosci, 2012. PMID 22988430, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. USP15 Deubiquitinates TUT1 Associated with RNA Metabolism and Maintains Cerebellar Homeostasis.
      Title: USP15 Deubiquitinates TUT1 Associated with RNA Metabolism and Maintains Cerebellar Homeostasis.
    2. TUT1 nucleotidyl transferase interacts with LARP7 protein to regulate Lin28 expression.
      Title: Primordial dwarfism gene maintains Lin28 expression to safeguard embryonic stem cells from premature differentiation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA uridylyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables U6 snRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables enzyme-substrate adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA 3'-UTR binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables poly(A) RNA polymerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables poly(A) RNA polymerase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in U6 snRNA 3'-end processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA 3'-end processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in snRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of mRNA cleavage and polyadenylation specificity factor complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nuclear speck IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    speckle targeted PIP5K1A-regulated poly(A) polymerase
    Names
    RNA binding motif protein 21
    NP_932110.1
    XP_030106934.1
    XP_036017576.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_197993.4 → NP_932110.1  speckle targeted PIP5K1A-regulated poly(A) polymerase

      See identical proteins and their annotated locations for NP_932110.1

      Status: VALIDATED

      Source sequence(s)
      AC130819
      Consensus CDS
      CCDS29562.1
      UniProtKB/Swiss-Prot
      Q3UUH3, Q8R3F9
      Related
      ENSMUSP00000093958.6, ENSMUST00000096239.7
      Conserved Domains (4) summary
      cd05402
      Location:179 → 403
      NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
      smart00451
      Location:14 → 47
      ZnF_U1; U1-like zinc finger
      COG0724
      Location:56 → 140
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12279
      Location:54 → 127
      RRM_TUT1; RNA recognition motif in speckle targeted PIP5K1A-regulated poly(A) polymerase (Star-PAP) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      8931199..8943572
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030251074.2 → XP_030106934.1  speckle targeted PIP5K1A-regulated poly(A) polymerase isoform X1

      Conserved Domains (3) summary
      cd05402
      Location:81 → 305
      NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
      COG5260
      Location:262 → 355
      TRF4; DNA polymerase sigma [Replication, recombination and repair]
      cl17169
      Location:1 → 29
      RRM_SF; RNA recognition motif (RRM) superfamily

    2. XM_036161683.1 → XP_036017576.1  speckle targeted PIP5K1A-regulated poly(A) polymerase isoform X2

      Conserved Domains (2) summary
      pfam03828
      Location:89 → 148
      PAP_assoc; Cid1 family poly A polymerase
      pfam19088
      Location:4 → 50
      TUTase; TUTase nucleotidyltransferase domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R3F9.1 GenPept UniProtKB/Swiss-Prot:Q8R3F9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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