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    Kcnh8 potassium voltage-gated channel, subfamily H (eag-related), member 8 [ Mus musculus (house mouse) ]

    Gene ID: 211468, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Kcnh8provided by MGI
    Official Full Name
    potassium voltage-gated channel, subfamily H (eag-related), member 8provided by MGI
    Primary source
    MGI:MGI:2445160
    See related
    Ensembl:ENSMUSG00000035580 AllianceGenome:MGI:2445160
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ELK; ELK1; ELK3; Kv12.1; C130090D05Rik
    Summary
    Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and voltage-gated potassium channel activity. Predicted to be involved in negative regulation of apoptotic process; potassium ion transmembrane transport; and regulation of membrane potential. Predicted to act upstream of or within ion transport and regulation of ion transmembrane transport. Predicted to be located in plasma membrane. Predicted to be integral component of plasma membrane. Orthologous to human KCNH8 (potassium voltage-gated channel subfamily H member 8). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in whole brain E14.5 (RPKM 1.5), CNS E14 (RPKM 1.3) and 9 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    17 C; 17 27.37 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (52909535..53286892)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (52602709..52979194)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_42815 Neighboring gene predicted gene, 41600 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:52607808-52608039 Neighboring gene predicted gene 5094 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:52740540-52740828 Neighboring gene predicted gene 27217 Neighboring gene STARR-seq mESC enhancer starr_42820 Neighboring gene STARR-seq mESC enhancer starr_42821 Neighboring gene STARR-seq mESC enhancer starr_42822 Neighboring gene STARR-seq mESC enhancer starr_42824 Neighboring gene STARR-seq mESC enhancer starr_42825 Neighboring gene STARR-seq mESC enhancer starr_42826 Neighboring gene STARR-seq mESC enhancer starr_42827 Neighboring gene 3-phosphoglycerate dehydrogenase pseudogene Neighboring gene thioredoxin-like protein 4A pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Divalent cations slow activation of EAG family K+ channels through direct binding to S4. Zhang X, et al. Biophys J, 2009 Jul 8. PMID 19580749, Free PMC Article
    2. Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development. Harrell MD, et al. Physiol Genomics, 2007 Feb 12. PMID 16985003
    3. Brn3a and Nurr1 mediate a gene regulatory pathway for habenula development. Quina LA, et al. J Neurosci, 2009 Nov 11. PMID 19906978, Free PMC Article
    4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables voltage-gated potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables voltage-gated potassium channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within potassium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of membrane potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of monoatomic ion channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    potassium voltage-gated channel subfamily H member 8
    Names
    ELK channel 3
    ether-a-go-go-like potassium channel 3
    potassium voltage-gated channel, subfamily H, member 8
    voltage-gated potassium channel subunit Kv12.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001031811.2 → NP_001026981.2  potassium voltage-gated channel subfamily H member 8

      Status: VALIDATED

      Source sequence(s)
      AC125051, AC131674, AK048629, BC029690, CJ165858
      Consensus CDS
      CCDS57101.1
      UniProtKB/Swiss-Prot
      P59111, Q8BX82
      UniProtKB/TrEMBL
      F6TUN6
      Related
      ENSMUSP00000049206.10, ENSMUST00000039366.11
      Conserved Domains (6) summary
      COG0664
      Location:548 → 707
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      cd00038
      Location:551 → 662
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd00130
      Location:42 → 133
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam00520
      Location:239 → 481
      Ion_trans; Ion transport protein
      pfam07885
      Location:421 → 475
      Ion_trans_2; Ion channel
      pfam13426
      Location:29 → 135
      PAS_9; PAS domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      52909535..53286892
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160442.1 → XP_036016335.1  potassium voltage-gated channel subfamily H member 8 isoform X1

      UniProtKB/Swiss-Prot
      P59111, Q8BX82
      Conserved Domains (3) summary
      PLN03192
      Location:175 → 616
      PLN03192; Voltage-dependent potassium channel; Provisional
      COG0664
      Location:549 → 708
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      pfam13426
      Location:40 → 135
      PAS_9; PAS domain

    2. XM_036160443.1 → XP_036016336.1  potassium voltage-gated channel subfamily H member 8 isoform X2

      UniProtKB/Swiss-Prot
      P59111, Q8BX82
      Conserved Domains (3) summary
      PLN03192
      Location:97 → 538
      PLN03192; Voltage-dependent potassium channel; Provisional
      COG0664
      Location:471 → 630
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      pfam13426
      Location:15 → 57
      PAS_9; PAS domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P59111.2 GenPept UniProtKB/Swiss-Prot:P59111

    Gene LinkOut

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