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    Kctd18 potassium channel tetramerisation domain containing 18 [ Mus musculus (house mouse) ]

    Gene ID: 51960, updated on 23-Mar-2024

    Summary

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    Official Symbol
    Kctd18provided by MGI
    Official Full Name
    potassium channel tetramerisation domain containing 18provided by MGI
    Primary source
    MGI:MGI:3603813
    See related
    Ensembl:ENSMUSG00000054770 AllianceGenome:MGI:3603813
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4932411A20Rik; 6530404F10Rik
    Summary
    Is expressed in central nervous system and retina. Orthologous to human KCTD18 (potassium channel tetramerization domain containing 18). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 4.0), CNS E14 (RPKM 3.8) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Kctd18 in Genome Data Viewer
    Location:
    1 C1.3; 1 28.86 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (57994260..58009298, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (57955101..57970141, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_00995 Neighboring gene STARR-seq mESC enhancer starr_00996 Neighboring gene predicted gene, 57573 Neighboring gene spermatogenesis associated, serine-rich 2-like Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:57896765-57896993 Neighboring gene STARR-seq mESC enhancer starr_00998 Neighboring gene predicted gene, 57576 Neighboring gene STARR-positive B cell enhancer ABC_E7730 Neighboring gene STARR-seq mESC enhancer starr_01001 Neighboring gene shugoshin 2A Neighboring gene STARR-seq mESC enhancer starr_01003 Neighboring gene aldehyde oxidase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Gene expression in the developing mouse retina by EST sequencing and microarray analysis. Mu X, et al. Nucleic Acids Res, 2001 Dec 15. PMID 11812828, Free PMC Article
    2. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    3. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
    4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    BTB/POZ domain-containing protein KCTD18

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159864.2 → NP_001153336.2  BTB/POZ domain-containing protein KCTD18 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC110735
      Consensus CDS
      CCDS48269.1
      Related
      ENSMUSP00000110052.4, ENSMUST00000114410.10

    2. NM_001159865.2 → NP_001153337.2  BTB/POZ domain-containing protein KCTD18 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC110735
      Consensus CDS
      CCDS48268.1
      Related
      ENSMUSP00000130952.2, ENSMUST00000164963.8

    3. NM_001428727.1 → NP_001415656.1  BTB/POZ domain-containing protein KCTD18 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC110735

    4. NM_001428728.1 → NP_001415657.1  BTB/POZ domain-containing protein KCTD18 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC110735

    5. NM_001428729.1 → NP_001415658.1  BTB/POZ domain-containing protein KCTD18 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC110735

    6. NM_001428730.1 → NP_001415659.1  BTB/POZ domain-containing protein KCTD18 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC110735

    7. NM_001428731.1 → NP_001415660.1  BTB/POZ domain-containing protein KCTD18 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC110735

    8. NM_001428732.1 → NP_001415661.1  BTB/POZ domain-containing protein KCTD18 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC110735

    9. NM_001428733.1 → NP_001415662.1  BTB/POZ domain-containing protein KCTD18 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC110735

    10. NM_001428734.1 → NP_001415663.1  BTB/POZ domain-containing protein KCTD18 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC110735

    11. NM_001428735.1 → NP_001415664.1  BTB/POZ domain-containing protein KCTD18 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC110735

    RNA

    1. NR_027630.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC110735
      Related
      ENSMUST00000161608.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      57994260..58009298 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006496136.5 → XP_006496199.1  BTB/POZ domain-containing protein KCTD18 isoform X1

      Conserved Domains (2) summary
      cd18372
      Location:23 → 123
      BTB_POZ_KCTD18; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 18 (KCTD18)
      pfam17669
      Location:339 → 414
      DUF5529; Family of unknown function (DUF5529)

    2. XM_036152324.1 → XP_036008217.1  BTB/POZ domain-containing protein KCTD18 isoform X3

      Conserved Domains (1) summary
      cl38908
      Location:23 → 107
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

    3. XM_006496135.4 → XP_006496198.1  BTB/POZ domain-containing protein KCTD18 isoform X1

      Conserved Domains (2) summary
      cd18372
      Location:23 → 123
      BTB_POZ_KCTD18; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 18 (KCTD18)
      pfam17669
      Location:339 → 414
      DUF5529; Family of unknown function (DUF5529)

    4. XM_017321677.3 → XP_017177166.1  BTB/POZ domain-containing protein KCTD18 isoform X4

    5. XM_017321676.3 → XP_017177165.1  BTB/POZ domain-containing protein KCTD18 isoform X2

      Conserved Domains (1) summary
      pfam17669
      Location:218 → 293
      DUF5529; Family of unknown function (DUF5529)

    6. XM_036152329.1 → XP_036008222.1  BTB/POZ domain-containing protein KCTD18 isoform X4

      Conserved Domains (1) summary
      pfam15323
      Location:66 → 174
      Ashwin; Developmental protein

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_030211.3: Suppressed sequence

      Description
      NM_030211.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein, and the transcript appears to retain intronic sequence at its 3' end.
    Nucleotide Protein Strain
    Heading Accession and Version

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