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    C1qtnf4 C1q and tumor necrosis factor related protein 4 [ Mus musculus (house mouse) ]

    Gene ID: 67445, updated on 5-Mar-2024

    Summary

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    Official Symbol
    C1qtnf4provided by MGI
    Official Full Name
    C1q and tumor necrosis factor related protein 4provided by MGI
    Primary source
    MGI:MGI:1914695
    See related
    Ensembl:ENSMUSG00000040794 AllianceGenome:MGI:1914695
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Adin; CTRP4; 0710001E10Rik; 9430004J15Rik
    Summary
    Predicted to enable cytokine activity. Predicted to be involved in positive regulation of cytokine production and positive regulation of signal transduction. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in brain and retina. Orthologous to human C1QTNF4 (C1q and TNF related 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis adult (RPKM 119.2), frontal lobe adult (RPKM 74.2) and 7 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See C1qtnf4 in Genome Data Viewer
    Location:
    2 E1; 2 50.43 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (90713132..90720870)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (90882788..90890526)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene ATP/GTP binding protein-like 2 Neighboring gene STARR-seq mESC enhancer starr_05097 Neighboring gene predicted gene 13772 Neighboring gene STARR-seq mESC enhancer starr_05098 Neighboring gene STARR-positive B cell enhancer ABC_E11147 Neighboring gene mitochondrial carrier 2 Neighboring gene STARR-positive B cell enhancer ABC_E9517 Neighboring gene predicted gene, 32514 Neighboring gene NADH:ubiquinone oxidoreductase core subunit S3 Neighboring gene predicted gene, 54113

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. CTRP4 ablation impairs associative learning and memory. Sarver DC, et al. FASEB J, 2021 Nov. PMID 34610176, Free PMC Article
    2. CTRP4 acts as an anti-inflammatory factor in macrophages and protects against endotoxic shock. Cao L, et al. Eur J Immunol, 2021 Feb. PMID 33080044
    3. Loss of CTRP4 alters adiposity and food intake behaviors in obese mice. Sarver DC, et al. Am J Physiol Endocrinol Metab, 2020 Dec 1. PMID 33017221, Free PMC Article
    4. C1q/TNF-related Protein 4 Induces Signal Transducer and Activator of Transcription 3 Pathway and Modulates Food Intake. Li Y, et al. Neuroscience, 2020 Mar 1. PMID 31917347
    5. Ctrp4, a new adipokine, promotes the differentiation of osteoblasts. Li Q, et al. Biochem Biophys Res Commun, 2019 Apr 30. PMID 30885436

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. C1q/TNF-related protein 4 restores leptin sensitivity by downregulating NF-kappaB signaling and microglial activation.
      Title: C1q/TNF-related protein 4 restores leptin sensitivity by downregulating NF-κB signaling and microglial activation.
    2. C1q/TNF-related Protein 4 Induces Signal Transducer and Activator of Transcription 3 Pathway and Modulates Food Intake.
      Title: C1q/TNF-related Protein 4 Induces Signal Transducer and Activator of Transcription 3 Pathway and Modulates Food Intake.
    3. CTRP4 acts as an anti-inflammatory factor in macrophages and protects against endotoxic shock.
      Title: CTRP4 acts as an anti-inflammatory factor in macrophages and protects against endotoxic shock.
    4. These results suggest that Ctrp4 is involved in bone metabolism regulation and promotes osteoblast differentiation, which may become a potential target for future intervention in bone metabolic diseases.
      Title: Ctrp4, a new adipokine, promotes the differentiation of osteoblasts.
    5. CTRP4 plays an important role in inflammation and inflammation-associated colon tumorigenesis.
      Title: Expression of the novel adipokine C1qTNF-related protein 4 (CTRP4) suppresses colitis and colitis-associated colorectal cancer in mice.
    6. These results establish CTRP4 as a novel nutrient-responsive central regulator of food intake and energy balance.
      Title: C1q/TNF-related protein 4 (CTRP4) is a unique secreted protein with two tandem C1q domains that functions in the hypothalamus to modulate food intake and body weight.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 
    • Endonuclease-mediated (4)  1 citation

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cytokine activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of interleukin-6 production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of interleukin-6-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of non-canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of tumor necrosis factor production ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    complement C1q tumor necrosis factor-related protein 4
    Names
    C1q/TNF-related protein 4
    adiponectin n

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026161.3 → NP_080437.2  complement C1q tumor necrosis factor-related protein 4 precursor

      See identical proteins and their annotated locations for NP_080437.2

      Status: VALIDATED

      Source sequence(s)
      AK029777, BF458176, CX243534, DQ002397
      Consensus CDS
      CCDS16417.2
      UniProtKB/Swiss-Prot
      A2AFW1, Q4ZJN5, Q8R066, Q9D0W2, Q9DCB6
      UniProtKB/TrEMBL
      A0A3B0IP17
      Related
      ENSMUSP00000107091.3, ENSMUST00000111466.3
      Conserved Domains (1) summary
      pfam00386
      Location:30 → 155
      C1q; C1q domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      90713132..90720870
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030251995.1 → XP_030107855.1  complement C1q tumor necrosis factor-related protein 4 isoform X1

      UniProtKB/Swiss-Prot
      A2AFW1, Q4ZJN5, Q8R066, Q9D0W2, Q9DCB6
      UniProtKB/TrEMBL
      A0A3B0IP17
      Conserved Domains (1) summary
      pfam00386
      Location:30 → 155
      C1q; C1q domain

    2. XM_006500080.4 → XP_006500143.1  complement C1q tumor necrosis factor-related protein 4 isoform X1

      See identical proteins and their annotated locations for XP_006500143.1

      UniProtKB/Swiss-Prot
      A2AFW1, Q4ZJN5, Q8R066, Q9D0W2, Q9DCB6
      UniProtKB/TrEMBL
      A0A3B0IP17
      Conserved Domains (1) summary
      pfam00386
      Location:30 → 155
      C1q; C1q domain

    3. XM_006500079.2 → XP_006500142.1  complement C1q tumor necrosis factor-related protein 4 isoform X1

      See identical proteins and their annotated locations for XP_006500142.1

      UniProtKB/Swiss-Prot
      A2AFW1, Q4ZJN5, Q8R066, Q9D0W2, Q9DCB6
      UniProtKB/TrEMBL
      A0A3B0IP17
      Conserved Domains (1) summary
      pfam00386
      Location:30 → 155
      C1q; C1q domain

    4. XM_030251994.2 → XP_030107854.1  complement C1q tumor necrosis factor-related protein 4 isoform X1

      UniProtKB/Swiss-Prot
      A2AFW1, Q4ZJN5, Q8R066, Q9D0W2, Q9DCB6
      UniProtKB/TrEMBL
      A0A3B0IP17
      Conserved Domains (1) summary
      pfam00386
      Location:30 → 155
      C1q; C1q domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R066.1 GenPept UniProtKB/Swiss-Prot:Q8R066

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