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    Fer1l6 fer-1 like family member 6 [ Mus musculus (house mouse) ]

    Gene ID: 631797, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Fer1l6provided by MGI
    Official Full Name
    fer-1 like family member 6provided by MGI
    Primary source
    MGI:MGI:3645398
    See related
    Ensembl:ENSMUSG00000037106 AllianceGenome:MGI:3645398
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    EG631797
    Summary
    Acts upstream of or within response to bacterium. Orthologous to human FER1L6 (fer-1 like family member 6). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in colon adult (RPKM 6.1), large intestine adult (RPKM 2.6) and 4 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    15 D1; 15 24.88 cM
    Exon count:
    42
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (58381897..58536936)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (58510048..58665087)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53238 Neighboring gene annexin A13 Neighboring gene STARR-positive B cell enhancer ABC_E7369 Neighboring gene STARR-seq mESC enhancer starr_38755 Neighboring gene family with sequence similarity 91, member A1 Neighboring gene STARR-seq mESC enhancer starr_38756 Neighboring gene STARR-seq mESC enhancer starr_38757 Neighboring gene STARR-seq mESC enhancer starr_38758 Neighboring gene predicted gene, 36451 Neighboring gene STARR-seq mESC enhancer starr_38759 Neighboring gene predicted gene, 41329 Neighboring gene transmembrane protein 65 Neighboring gene predicted gene, 24041

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Testis-enriched ferlin, FER1L5, is required for Ca(2+)-activated acrosome reaction and male fertility. Morohoshi A, et al. Sci Adv, 2023 Jan 25. PMID 36696506, Free PMC Article
    2. Impact of lactobacilli on orally acquired listeriosis. Archambaud C, et al. Proc Natl Acad Sci U S A, 2012 Oct 9. PMID 23012479, Free PMC Article
    3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (3) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in plasma membrane organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within response to bacterium IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    fer-1-like protein 6
    Names
    fer-1-like 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001370912.1 → NP_001357841.1  fer-1-like protein 6

      Status: VALIDATED

      Source sequence(s)
      AC107742, AC107775, AC163393
      UniProtKB/TrEMBL
      E0CZ42
      Related
      ENSMUSP00000125718.2, ENSMUST00000161028.2
      Conserved Domains (8) summary
      cd04011
      Location:89 → 198
      C2B_Ferlin; C2 domain second repeat in Ferlin
      cd04017
      Location:838 → 971
      C2D_Ferlin; C2 domain fourth repeat in Ferlin
      cd04018
      Location:253 → 404
      C2C_Ferlin; C2 domain third repeat in Ferlin
      cd04037
      Location:1372 → 1495
      C2E_Ferlin; C2 domain fifth repeat in Ferlin
      cd08374
      Location:1612 → 1745
      C2F_Ferlin; C2 domain sixth repeat in Ferlin
      pfam08150
      Location:725 → 796
      FerB; FerB (NUC096) domain
      pfam08151
      Location:196 → 245
      FerI; FerI (NUC094) domain
      pfam16165
      Location:1756 → 1868
      Ferlin_C; Ferlin C-terminus

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      58381897..58536936
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006521609.3 → XP_006521672.2  fer-1-like protein 6 isoform X1

      See identical proteins and their annotated locations for XP_006521672.2

      UniProtKB/TrEMBL
      E0CZ42
      Conserved Domains (8) summary
      cd04011
      Location:79 → 188
      C2B_Ferlin; C2 domain second repeat in Ferlin
      cd04017
      Location:828 → 961
      C2D_Ferlin; C2 domain fourth repeat in Ferlin
      cd04018
      Location:243 → 394
      C2C_Ferlin; C2 domain third repeat in Ferlin
      cd04037
      Location:1362 → 1485
      C2E_Ferlin; C2 domain fifth repeat in Ferlin
      cd08374
      Location:1602 → 1735
      C2F_Ferlin; C2 domain sixth repeat in Ferlin
      pfam08150
      Location:715 → 786
      FerB; FerB (NUC096) domain
      pfam08151
      Location:186 → 235
      FerI; FerI (NUC094) domain
      pfam16165
      Location:1746 → 1858
      Ferlin_C; Ferlin C-terminus

    2. XM_006521610.5 → XP_006521673.1  fer-1-like protein 6 isoform X2

      See identical proteins and their annotated locations for XP_006521673.1

      Conserved Domains (4) summary
      cd04037
      Location:485 → 608
      C2E_Ferlin; C2 domain fifth repeat in Ferlin
      cd08374
      Location:725 → 858
      C2F_Ferlin; C2 domain sixth repeat in Ferlin
      pfam16165
      Location:869 → 981
      Ferlin_C; Ferlin C-terminus
      cl14603
      Location:1 → 84
      C2; C2 domain
    Nucleotide Protein
    Heading Accession and Version

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