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    Rassf2 Ras association (RalGDS/AF-6) domain family member 2 [ Mus musculus (house mouse) ]

    Gene ID: 215653, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Rassf2provided by MGI
    Official Full Name
    Ras association (RalGDS/AF-6) domain family member 2provided by MGI
    Primary source
    MGI:MGI:2442060
    See related
    Ensembl:ENSMUSG00000027339 AllianceGenome:MGI:2442060
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    3830431H01Rik; 9030412M04Rik
    Summary
    Predicted to enable protein kinase activity. Acts upstream of or within several processes, including epidermal growth factor receptor signaling pathway via I-kappaB kinase/NF-kappaB cascade; negative regulation of NIK/NF-kappaB signaling; and regulation of osteoclast differentiation. Located in cytoplasm and nucleus. Is expressed in central nervous system; heart valve; and urinary system. Orthologous to human RASSF2 (Ras association domain family member 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in thymus adult (RPKM 18.3), spleen adult (RPKM 16.9) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    2 F2; 2 64.14 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (131834770..131872336, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (131992850..132030416, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_05721 Neighboring gene STARR-seq mESC enhancer starr_05722 Neighboring gene prion protein Neighboring gene prion protein readthrough transcript Neighboring gene STARR-seq mESC enhancer starr_05723 Neighboring gene prion like protein doppel Neighboring gene STARR-positive B cell enhancer mm9_chr2:131844916-131845217 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:131846634-131846817 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:131855025-131855212 Neighboring gene STARR-positive B cell enhancer ABC_E9533 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:131861333-131861539 Neighboring gene predicted gene, 31179 Neighboring gene STARR-positive B cell enhancer ABC_E5986 Neighboring gene solute carrier family 23 (nucleobase transporters), member 2 Neighboring gene STARR-positive B cell enhancer ABC_E10148 Neighboring gene STARR-positive B cell enhancer ABC_E8794 Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Ablation of Rassf2 induces bone defects and subsequent haematopoietic anomalies in mice. Song H, et al. EMBO J, 2012 Mar 7. PMID 22227519, Free PMC Article
    2. Role of the tumor suppressor RASSF2 in regulation of MST1 kinase activity. Song H, et al. Biochem Biophys Res Commun, 2010 Jan 1. PMID 19962960
    3. Expression profiling identifies novel candidate genes for ethanol sensitivity QTLs. MacLaren EJ, et al. Mamm Genome, 2006 Feb. PMID 16465594, Free PMC Article
    4. Atlas of gene expression in the developing kidney at microanatomic resolution. Brunskill EW, et al. Dev Cell, 2008 Nov. PMID 19000842, Free PMC Article
    5. Viral Infection-Induced Differential Expression of LncRNAs Associated with Collagen in Mouse Placentas and Amniotic Sacs. Pan J, et al. Am J Reprod Immunol, 2015 Sep. PMID 26073538

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (4) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within bone remodeling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within canonical NF-kappaB signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within homeostasis of number of cells IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of non-canonical NF-kappaB signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within ossification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of JNK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of JNK cascade ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in positive regulation of protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in protein stabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of non-canonical NF-kappaB signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of non-canonical NF-kappaB signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of osteoblast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of osteoclast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within skeletal system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ras association domain-containing protein 2
    Names
    Ras association (RalGDS/AF-6) domain family 2

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001362866.1 → NP_001349795.1  ras association domain-containing protein 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AL833794, AL929513
      Consensus CDS
      CCDS16768.1
      UniProtKB/Swiss-Prot
      Q6A0B2, Q8BMS9
      Related
      ENSMUSP00000099471.2, ENSMUST00000103182.8
      Conserved Domains (2) summary
      cd17221
      Location:177 → 263
      RA_RASSF2; Ras-associating (RA) domain found in Ras-association domain-containing protein 2 (RASSF2)
      pfam16517
      Location:277 → 316
      Nore1-SARAH; Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain

    2. NM_175445.4 → NP_780654.1  ras association domain-containing protein 2

      See identical proteins and their annotated locations for NP_780654.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AL833794, BC057402, BQ770520
      Consensus CDS
      CCDS16768.1
      UniProtKB/Swiss-Prot
      Q6A0B2, Q8BMS9
      Related
      ENSMUSP00000028814.9, ENSMUST00000028814.15
      Conserved Domains (2) summary
      cd17221
      Location:177 → 263
      RA_RASSF2; Ras-associating (RA) domain found in Ras-association domain-containing protein 2 (RASSF2)
      pfam16517
      Location:277 → 316
      Nore1-SARAH; Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      131834770..131872336 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006499140.4 → XP_006499203.1  ras association domain-containing protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006499203.1

      UniProtKB/Swiss-Prot
      Q6A0B2, Q8BMS9
      Conserved Domains (2) summary
      cd17221
      Location:177 → 263
      RA_RASSF2; Ras-associating (RA) domain found in Ras-association domain-containing protein 2 (RASSF2)
      pfam16517
      Location:277 → 316
      Nore1-SARAH; Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain

    2. XM_006499139.5 → XP_006499202.1  ras association domain-containing protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006499202.1

      UniProtKB/Swiss-Prot
      Q6A0B2, Q8BMS9
      Conserved Domains (2) summary
      cd17221
      Location:177 → 263
      RA_RASSF2; Ras-associating (RA) domain found in Ras-association domain-containing protein 2 (RASSF2)
      pfam16517
      Location:277 → 316
      Nore1-SARAH; Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain

    3. XM_006499144.5 → XP_006499207.1  ras association domain-containing protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006499207.1

      UniProtKB/Swiss-Prot
      Q6A0B2, Q8BMS9
      Conserved Domains (2) summary
      cd17221
      Location:177 → 263
      RA_RASSF2; Ras-associating (RA) domain found in Ras-association domain-containing protein 2 (RASSF2)
      pfam16517
      Location:277 → 316
      Nore1-SARAH; Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain

    4. XM_006499141.4 → XP_006499204.1  ras association domain-containing protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006499204.1

      UniProtKB/Swiss-Prot
      Q6A0B2, Q8BMS9
      Conserved Domains (2) summary
      cd17221
      Location:177 → 263
      RA_RASSF2; Ras-associating (RA) domain found in Ras-association domain-containing protein 2 (RASSF2)
      pfam16517
      Location:277 → 316
      Nore1-SARAH; Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BMS9.1 GenPept UniProtKB/Swiss-Prot:Q8BMS9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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