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    Zdhhc6 zinc finger, DHHC domain containing 6 [ Mus musculus (house mouse) ]

    Gene ID: 66980, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Zdhhc6provided by MGI
    Official Full Name
    zinc finger, DHHC domain containing 6provided by MGI
    Primary source
    MGI:MGI:1914230
    See related
    Ensembl:ENSMUSG00000024982 AllianceGenome:MGI:1914230
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DHHC-6; 2400007G07Rik; 5930409M18Rik
    Summary
    Predicted to enable protein-cysteine S-palmitoyltransferase activity. Involved in protein palmitoylation. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus and endoplasmic reticulum. Is expressed in several structures, including eye; genitourinary system; heart; lung epithelium; and trunk somite. Orthologous to human ZDHHC6 (zinc finger DHHC-type palmitoyltransferase 6). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in bladder adult (RPKM 8.6), kidney adult (RPKM 8.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zdhhc6 in Genome Data Viewer
    Location:
    19 D2; 19 51.33 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (55286648..55304468, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (55298216..55316036, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_46491 Neighboring gene STARR-seq mESC enhancer starr_46492 Neighboring gene guanylate cyclase 2g Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:55328374-55328561 Neighboring gene STARR-positive B cell enhancer ABC_E8758 Neighboring gene acyl-CoA synthetase long-chain family member 5 Neighboring gene predicted gene, 31595 Neighboring gene STARR-positive B cell enhancer ABC_E7673 Neighboring gene vesicle transport through interaction with t-SNAREs 1A Neighboring gene STARR-seq mESC enhancer starr_46494 Neighboring gene STARR-seq mESC enhancer starr_46495 Neighboring gene STARR-seq mESC enhancer starr_46496 Neighboring gene STARR-seq mESC enhancer starr_46497 Neighboring gene STARR-seq mESC enhancer starr_46499 Neighboring gene STARR-positive B cell enhancer ABC_E2531 Neighboring gene STARR-positive B cell enhancer ABC_E2532 Neighboring gene RIKEN cDNA 4930552P12 gene Neighboring gene STARR-positive B cell enhancer ABC_E7674 Neighboring gene STARR-positive B cell enhancer ABC_E11041 Neighboring gene predicted gene, 41871

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Astrocyte Elevated Gene-1 Cys75 S-Palmitoylation by ZDHHC6 Regulates Its Biological Activity. Komaniecki G, et al. Biochemistry, 2023 Jan 17. PMID 36548985, Free PMC Article
    2. Local Palmitoylation Cycles and Specialized Membrane Domain Organization. Fukata Y, et al. Curr Top Membr, 2016. PMID 26781831
    3. Mechanistic effects of protein palmitoylation and the cellular consequences thereof. Blaskovic S, et al. Chem Phys Lipids, 2014 May. PMID 24534427
    4. Palmitoylation and the trafficking of peripheral membrane proteins. Chamberlain LH, et al. Biochem Soc Trans, 2013 Feb 1. PMID 23356259
    5. Palmitoylation and depalmitoylation dynamics at a glance. Conibear E, et al. J Cell Sci, 2010 Dec 1. PMID 21084560, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Astrocyte Elevated Gene-1 Cys75 S-Palmitoylation by ZDHHC6 Regulates Its Biological Activity.
      Title: Astrocyte Elevated Gene-1 Cys75 S-Palmitoylation by ZDHHC6 Regulates Its Biological Activity.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables palmitoyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-cysteine S-palmitoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-cysteine S-stearoyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in peptidyl-L-cysteine S-palmitoylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of mitochondrial fusion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein palmitoylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein palmitoylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein stearoylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein targeting to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    palmitoyltransferase ZDHHC6
    Names
    H4 homolog
    stearoyltransferase ZDHHC6
    zinc finger DHHC domain-containing protein 6
    NP_001028745.1
    NP_001347524.1
    NP_080159.3
    XP_006527331.1
    XP_011245618.1
    XP_030106892.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033573.2 → NP_001028745.1  palmitoyltransferase ZDHHC6 isoform 1

      See identical proteins and their annotated locations for NP_001028745.1

      Status: VALIDATED

      Source sequence(s)
      AC133100, AK050388, AK159304, BY109555
      Consensus CDS
      CCDS29909.1
      UniProtKB/Swiss-Prot
      Q3U3I8, Q3UT70, Q544H1, Q9CPV7
      Related
      ENSMUSP00000076157.6, ENSMUST00000076891.7
      Conserved Domains (2) summary
      pfam01529
      Location:95 → 241
      DHHC; DHHC palmitoyltransferase
      pfam07653
      Location:317 → 396
      SH3_2; Variant SH3 domain

    2. NM_001360595.1 → NP_001347524.1  palmitoyltransferase ZDHHC6 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC133100
      Conserved Domains (1) summary
      pfam01529
      Location:95 → 241
      zf-DHHC; DHHC palmitoyltransferase

    3. NM_025883.4 → NP_080159.3  palmitoyltransferase ZDHHC6 isoform 1

      See identical proteins and their annotated locations for NP_080159.3

      Status: VALIDATED

      Source sequence(s)
      AC133100, AK159304
      Consensus CDS
      CCDS29909.1
      UniProtKB/Swiss-Prot
      Q3U3I8, Q3UT70, Q544H1, Q9CPV7
      Related
      ENSMUSP00000153014.2, ENSMUST00000224897.2
      Conserved Domains (2) summary
      pfam01529
      Location:95 → 241
      DHHC; DHHC palmitoyltransferase
      pfam07653
      Location:317 → 396
      SH3_2; Variant SH3 domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      55286648..55304468 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011247316.3 → XP_011245618.1  palmitoyltransferase ZDHHC6 isoform X1

      See identical proteins and their annotated locations for XP_011245618.1

      UniProtKB/Swiss-Prot
      Q3U3I8, Q3UT70, Q544H1, Q9CPV7
      Conserved Domains (2) summary
      pfam01529
      Location:95 → 241
      DHHC; DHHC palmitoyltransferase
      pfam07653
      Location:317 → 396
      SH3_2; Variant SH3 domain

    2. XM_006527268.4 → XP_006527331.1  palmitoyltransferase ZDHHC6 isoform X1

      See identical proteins and their annotated locations for XP_006527331.1

      UniProtKB/Swiss-Prot
      Q3U3I8, Q3UT70, Q544H1, Q9CPV7
      Conserved Domains (2) summary
      pfam01529
      Location:95 → 241
      DHHC; DHHC palmitoyltransferase
      pfam07653
      Location:317 → 396
      SH3_2; Variant SH3 domain

    3. XM_030251032.1 → XP_030106892.1  palmitoyltransferase ZDHHC6 isoform X2

      Conserved Domains (1) summary
      pfam07653
      Location:213 → 292
      SH3_2; Variant SH3 domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CPV7.1 GenPept UniProtKB/Swiss-Prot:Q9CPV7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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