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    Gas7 growth arrest specific 7 [ Mus musculus (house mouse) ]

    Gene ID: 14457, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Gas7provided by MGI
    Official Full Name
    growth arrest specific 7provided by MGI
    Primary source
    MGI:MGI:1202388
    See related
    Ensembl:ENSMUSG00000033066 AllianceGenome:MGI:1202388
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gas7-cb; B230343A10Rik
    Summary
    Enables actin filament binding activity. Acts upstream of or within actin filament organization; neuron projection morphogenesis; and regulation of cell shape. Located in actin filament and ruffle. Is expressed in forebrain. Orthologous to human GAS7 (growth arrest specific 7). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in cortex adult (RPKM 37.9), cerebellum adult (RPKM 29.9) and 15 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    11 B3; 11 41.13 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (67344083..67579818)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (67453257..67688992)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene myosin, heavy polypeptide 13, skeletal muscle Neighboring gene STARR-seq mESC enhancer starr_29800 Neighboring gene predicted gene, 40029 Neighboring gene predicted gene, 31459 Neighboring gene STARR-seq mESC enhancer starr_29801 Neighboring gene STARR-positive B cell enhancer ABC_E10680 Neighboring gene STARR-positive B cell enhancer ABC_E1827 Neighboring gene predicted gene 12301 Neighboring gene glucagon-like peptide 2 receptor Neighboring gene recoverin Neighboring gene STARR-seq mESC enhancer starr_29802 Neighboring gene GSG1-like 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Phagocytosis is mediated by two-dimensional assemblies of the F-BAR protein GAS7. Hanawa-Suetsugu K, et al. Nat Commun, 2019 Oct 18. PMID 31628328, Free PMC Article
    2. Growth arrest-specific protein 7 regulates the murine M1 alveolar macrophage polarization. Xu Q, et al. Immunol Res, 2017 Oct. PMID 28895026
    3. Direct optical microscopic observation of the microtubule polymerization intermediate sheet structure in the presence of gas7. Uchida T, et al. J Mol Biol, 2009 Sep 4. PMID 19580814
    4. Involvement of Gas7 in nerve growth factor-independent and dependent cell processes in PC12 cells. Chao CC, et al. J Neurosci Res, 2003 Oct 15. PMID 14515354
    5. The Gas7 gene encodes two protein isoforms differentially expressed within the brain. Lazakovitch EM, et al. Genomics, 1999 Nov 1. PMID 10552931

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Growth Arrest-Specific 7 (GAS7) plays a critical role in phagocytic cup formation in macrophages.
      Title: Phagocytosis is mediated by two-dimensional assemblies of the F-BAR protein GAS7.
    2. Gas7-related M1 gene expression in alveolar macrophage was not dependent on NF-kappaB and STAT1 pathway
      Title: Growth arrest-specific protein 7 regulates the murine M1 alveolar macrophage polarization.
    3. These results demonstrate GAS7 as a susceptibility gene for schizophrenia.
      Title: Growth arrest specific gene 7 is associated with schizophrenia and regulates neuronal migration and morphogenesis.
    4. Forced expression of Gas7a or Gas7b isoform in mouse neuroblastoma Neuro2A cells, which express a defective Gas7 gene, rendered the cells proapoptotic and vulnerable to cisplatin-induced apoptosis.
      Title: Knockdown of growth-arrest-specific gene 7b (gas7b) using short-hairpin RNA desensitizes neuroblastoma cells to cisplatin: Implications for preventing apoptosis of neurons.
    5. Gas7 works through its interaction with N-WASP during neuronal maturation/ differentiation
      Title: Gas7 functions with N-WASP to regulate the neurite outgrowth of hippocampal neurons.
    6. Gas7b has a role in microtubular maintenance
      Title: A novel role for hGas7b in microtubular maintenance: possible implication in tau-associated pathology in Alzheimer disease.
    7. These results suggest that Gas7 enhances microtubule polymerization by stabilizing sheet intermediates and is a useful tool for analyzing microtubule transformation.
      Title: Direct optical microscopic observation of the microtubule polymerization intermediate sheet structure in the presence of gas7.
    8. Hoxa7 and Hoxa9 contribute to hematopoietic progenitor homeostasis but are not necessary for MLL-GAS7-mediated leukemogenesis
      Title: Leukemic transformation of hematopoietic progenitors by MLL-GAS7 in the absence of Hoxa7 or Hoxa9.
    9. Our data reveal that Gas7 might play a role in cellular migration and cell protection in the ES cells of mouse embryo.
      Title: Expression of the Gas7 gene and Oct4 in embryonic stem cells of mice.
    10. The ability of gas7 to potentiate neuronal differentiation makes it a potential therapeutic target to promote re-establishment of neuronal connections in the injured or diseased brain, such as following stroke.
      Title: The gas7 protein potentiates NGF-mediated differentiation of PC12 cells.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin filament binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within actin filament bundle assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in actin filament polymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within actin filament polymerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within neuron differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in neuron projection morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within neuron projection morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of cell shape IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in actin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in actin filament IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in ruffle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    growth arrest-specific protein 7
    Names
    growth arrest-specific 7 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109657.4 → NP_001103127.1  growth arrest-specific protein 7 isoform b

      See identical proteins and their annotated locations for NP_001103127.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (b) is shorter and has a distinct N-terminus, compared to isoform a.
      Source sequence(s)
      AL596255, AL646097, AL662883
      Consensus CDS
      CCDS48821.1
      UniProtKB/Swiss-Prot
      Q60780, Q9QY25, Q9QY26, Q9QY34
      UniProtKB/TrEMBL
      Q3U432
      Related
      ENSMUSP00000104320.3, ENSMUST00000108680.3
      Conserved Domains (2) summary
      cd07649
      Location:154 → 386
      F-BAR_GAS7; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Growth Arrest Specific protein 7
      pfam16623
      Location:49 → 141
      WW_FCH_linker; Unstructured linker region between on GAS7 protein

    2. NM_001277079.1 → NP_001264008.1  growth arrest-specific protein 7 isoform c

      See identical proteins and their annotated locations for NP_001264008.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) has a shorter N-terminus, compared to isoform a.
      Source sequence(s)
      AK152149, AL646097, BU053145, CJ147966, CV562268
      Consensus CDS
      CCDS70210.1
      UniProtKB/Swiss-Prot
      Q60780, Q9QY25, Q9QY26, Q9QY34
      UniProtKB/TrEMBL
      B1ATI9
      Related
      ENSMUSP00001091663.1, ENSMUST00020183803.1
      Conserved Domains (2) summary
      cd07649
      Location:150 → 382
      F-BAR_GAS7; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Growth Arrest Specific protein 7
      pfam16623
      Location:45 → 137
      WW_FCH_linker; Unstructured linker region between on GAS7 protein

    3. NM_001277080.1 → NP_001264009.1  growth arrest-specific protein 7 isoform d

      See identical proteins and their annotated locations for NP_001264009.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate downstream start codon, compared to variant 1. The encoded isoform (d) is shorter and has a distinct N-terminus, compared to isoform a.
      Source sequence(s)
      AK152149, AL646097, CJ146254, CJ147966, CV562268
      UniProtKB/TrEMBL
      Q6A075
      Conserved Domains (2) summary
      cd07649
      Location:91 → 323
      F-BAR_GAS7; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Growth Arrest Specific protein 7
      pfam16623
      Location:33 → 78
      WW_FCH_linker; Unstructured linker region between on GAS7 protein

    4. NM_001402818.1 → NP_001389747.1  growth arrest-specific protein 7 isoform e

      Status: VALIDATED

      Source sequence(s)
      AL596255, AL646097, AL662883
      UniProtKB/TrEMBL
      F6QB26
      Related
      ENSMUSP00000104321.3, ENSMUST00000108681.9

    5. NM_001402819.1 → NP_001389748.1  growth arrest-specific protein 7 isoform f

      Status: VALIDATED

      Source sequence(s)
      AL596255, AL646097, AL662883

    6. NM_001402821.1 → NP_001389750.1  growth arrest-specific protein 7 isoform c

      Status: VALIDATED

      Source sequence(s)
      AL596255, AL646097, AL662883
      UniProtKB/TrEMBL
      B1ATI9

    7. NM_001402823.1 → NP_001389752.1  growth arrest-specific protein 7 isoform d

      Status: VALIDATED

      Source sequence(s)
      AL596255, AL646097, AL662883

    8. NM_001402824.1 → NP_001389753.1  growth arrest-specific protein 7 isoform d

      Status: VALIDATED

      Source sequence(s)
      AL596255, AL646097, AL662883

    9. NM_001402825.1 → NP_001389754.1  growth arrest-specific protein 7 isoform g

      Status: VALIDATED

      Source sequence(s)
      AL646097

    10. NM_008088.5 → NP_032114.2  growth arrest-specific protein 7 isoform a

      See identical proteins and their annotated locations for NP_032114.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AK076926, AK152149, AL596255, AL646097, CV562268
      UniProtKB/Swiss-Prot
      Q60780, Q9QY25, Q9QY26, Q9QY34
      UniProtKB/TrEMBL
      Q0VBR8
      Conserved Domains (2) summary
      cd07649
      Location:159 → 391
      F-BAR_GAS7; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Growth Arrest Specific protein 7
      pfam16623
      Location:54 → 146
      WW_FCH_linker; Unstructured linker region between on GAS7 protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      67344083..67579818
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030245564.1 → XP_030101424.1  growth arrest-specific protein 7 isoform X5

      UniProtKB/TrEMBL
      Q6A075
      Conserved Domains (2) summary
      cd07649
      Location:91 → 323
      F-BAR_GAS7; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Growth Arrest Specific protein 7
      pfam16623
      Location:33 → 78
      WW_FCH_linker; Unstructured linker region between on GAS7 protein

    2. XM_017314262.1 → XP_017169751.1  growth arrest-specific protein 7 isoform X3

      UniProtKB/Swiss-Prot
      Q60780, Q9QY25, Q9QY26, Q9QY34
      UniProtKB/TrEMBL
      B1ATI9
      Related
      ENSMUSP00000038420.6, ENSMUST00000041611.12
      Conserved Domains (2) summary
      cd07649
      Location:150 → 382
      F-BAR_GAS7; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Growth Arrest Specific protein 7
      pfam16623
      Location:45 → 137
      WW_FCH_linker; Unstructured linker region between on GAS7 protein

    3. XM_006532209.1 → XP_006532272.1  growth arrest-specific protein 7 isoform X5

      See identical proteins and their annotated locations for XP_006532272.1

      UniProtKB/TrEMBL
      Q6A075
      Conserved Domains (2) summary
      cd07649
      Location:91 → 323
      F-BAR_GAS7; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Growth Arrest Specific protein 7
      pfam16623
      Location:33 → 78
      WW_FCH_linker; Unstructured linker region between on GAS7 protein

    4. XM_006532208.4 → XP_006532271.1  growth arrest-specific protein 7 isoform X4

      UniProtKB/TrEMBL
      Q3U8N2
      Conserved Domains (2) summary
      cd07649
      Location:110 → 342
      F-BAR_GAS7; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Growth Arrest Specific protein 7
      pfam16623
      Location:14 → 97
      WW_FCH_linker; Unstructured linker region between on GAS7 protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q60780.1 GenPept UniProtKB/Swiss-Prot:Q60780

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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