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    Nsl1 NSL1, MIS12 kinetochore complex component [ Mus musculus (house mouse) ]

    Gene ID: 381318, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Nsl1provided by MGI
    Official Full Name
    NSL1, MIS12 kinetochore complex componentprovided by MGI
    Primary source
    MGI:MGI:2685830
    See related
    Ensembl:ENSMUSG00000062510 AllianceGenome:MGI:2685830
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm105; Gm984; 4833432M17Rik
    Summary
    Predicted to be involved in mitotic sister chromatid segregation. Predicted to act upstream of or within cell division and chromosome segregation. Predicted to be located in kinetochore and nuclear speck. Predicted to be part of MIS12/MIND type complex. Orthologous to human NSL1 (NSL1 component of MIS12 kinetochore complex). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in CNS E11.5 (RPKM 6.8), liver E14 (RPKM 5.6) and 13 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    1 H6; 1 96.28 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (190794710..190816755)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (191062996..191084558)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene feline leukemia virus subgroup C cellular receptor 1 Neighboring gene RIKEN cDNA A230020J21 gene Neighboring gene STARR-positive B cell enhancer ABC_E223 Neighboring gene spermatogenesis associated 45 Neighboring gene TatD DNase domain containing 3 Neighboring gene STARR-positive B cell enhancer ABC_E4404 Neighboring gene basic leucine zipper transcription factor, ATF-like 3 Neighboring gene predicted gene, 46178

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A blueprint for kinetochores - new insights into the molecular mechanics of cell division. Lampert F, et al. Nat Rev Mol Cell Biol, 2011 Jun 2. PMID 21633384
    2. The KMN protein network--chief conductors of the kinetochore orchestra. Varma D, et al. J Cell Sci, 2012 Dec 15. PMID 23418356, Free PMC Article
    3. The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells. Ray JP, et al. Immunity, 2015 Oct 20. PMID 26410627, Free PMC Article
    4. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
    5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in attachment of spindle microtubules to kinetochore NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within chromosome segregation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic sister chromatid segregation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of MIS12/MIND type complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of MIS12/MIND type complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of MIS12/MIND type complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in kinetochore NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in spindle pole NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    kinetochore-associated protein NSL1 homolog
    Names
    NSL1, MIND kinetochore complex component, homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_198654.3 → NP_941056.3  kinetochore-associated protein NSL1 homolog

      Status: VALIDATED

      Source sequence(s)
      AC138229
      Consensus CDS
      CCDS15614.1
      UniProtKB/Swiss-Prot
      Q8K305
      UniProtKB/TrEMBL
      E9QME3
      Related
      ENSMUSP00000077380.7, ENSMUST00000078259.8
      Conserved Domains (1) summary
      pfam08641
      Location:82 → 196
      Mis14; Kinetochore protein Mis14 like

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      190794710..190816755
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017321425.2 → XP_017176914.1  kinetochore-associated protein NSL1 homolog isoform X1

      Conserved Domains (1) summary
      pfam08641
      Location:44 → 158
      Mis14; Kinetochore protein Mis14 like

    2. XM_011238922.4 → XP_011237224.1  kinetochore-associated protein NSL1 homolog isoform X3

      UniProtKB/TrEMBL
      E9Q3W6, Q8CDX2
      Related
      ENSMUSP00000115289.2, ENSMUST00000139340.8
      Conserved Domains (1) summary
      pfam08641
      Location:82 → 169
      Mis14; Kinetochore protein Mis14 like

    3. XM_006497181.5 → XP_006497244.1  kinetochore-associated protein NSL1 homolog isoform X2

      See identical proteins and their annotated locations for XP_006497244.1

      UniProtKB/TrEMBL
      D3Z4S2
      Related
      ENSMUSP00000076220.6, ENSMUST00000076952.12
      Conserved Domains (1) summary
      pfam08641
      Location:82 → 167
      Mis14; Kinetochore protein Mis14 like
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K305.1 GenPept UniProtKB/Swiss-Prot:Q8K305

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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