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    Erdr1x erythroid differentiation regulator 1 x [ Mus musculus (house mouse) ]

    Gene ID: 170942, updated on 17-Feb-2024

    Summary

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    Official Symbol
    Erdr1xprovided by MGI
    Official Full Name
    erythroid differentiation regulator 1 xprovided by MGI
    Primary source
    MGI:MGI:2384747
    See related
    AllianceGenome:MGI:2384747
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    edr; Erdr1; Gm21887; Gm55594
    Summary
    Acts upstream of or within negative regulation of cell migration; negative regulation of cell population proliferation; and somatic stem cell population maintenance. Is expressed in several structures, including central nervous system and retina. [provided by Alliance of Genome Resources, Apr 2022]
    Annotation information
    Annotation category: suggests misassembly
    Annotation category: partial on reference assembly
    Note: Genetic polymorphisms result in both protein coding and non-coding alleles of this gene.
    Expression
    Ubiquitous expression in CNS E14 (RPKM 600.1), ovary adult (RPKM 558.4) and 24 other tissues See more
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    Genomic context

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    See Erdr1x in Genome Data Viewer
    Location:
    X;Y; X
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (168793522..168801793)
    RS_2024_02 current GRCm39 (GCF_000001635.27) Y NC_000087.8 (90796711..90827734)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (170010526..170018797)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) Y NC_000087.7 (90785442..90816465)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene midline 1 Neighboring gene RIKEN cDNA G530011O06 gene Neighboring gene STARR-positive B cell enhancer mm9_chrX:166413309-166413610 Neighboring gene STARR-positive B cell enhancer mm9_chrX:166414802-166415103 Neighboring gene STARR-positive B cell enhancer mm9_chrX:166415421-166415722 Neighboring gene STARR-positive B cell enhancer mm9_chrX:166417053-166417354 Neighboring gene STARR-positive B cell enhancer mm9_chrX:166417609-166417910 Neighboring gene STARR-positive B cell enhancer mm9_chrX:166419073-166419374 Neighboring gene STARR-positive B cell enhancer mm9_chrX:166420805-166421106 Neighboring gene STARR-positive B cell enhancer mm9_chrX:166422120-166422421 Neighboring gene STARR-seq mESC enhancer starr_48290 Neighboring gene predicted gene 15247 Neighboring gene steroid sulfatase Neighboring gene neuroligin 4-like

    Chromosome Y - NC_000087.8Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA G530011O06 gene Neighboring gene midline 1, pseudogene 1 Neighboring gene predicted gene 15247 Neighboring gene predicted gene, 33272 Neighboring gene predicted gene, 21748

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Commensal regulation of T cell survival through Erdr1. Weis AM, et al. Gut Microbes, 2018. PMID 29543554, Free PMC Article
    2. Microbiota promotes systemic T-cell survival through suppression of an apoptotic factor. Soto R, et al. Proc Natl Acad Sci U S A, 2017 May 23. PMID 28487480, Free PMC Article
    3. Erdr1 Suppresses Murine Melanoma Growth via Regulation of Apoptosis. Lee J, et al. Int J Mol Sci, 2016 Jan 14. PMID 26784177, Free PMC Article
    4. Erythroid differentiation regulator 1, an interleukin 18-regulated gene, acts as a metastasis suppressor in melanoma. Jung MK, et al. J Invest Dermatol, 2011 Oct. PMID 21697887
    5. EDR is a stress-related survival factor from stroma and other tissues acting on early haematopoietic progenitors (E-Mix). Dörmer P, et al. Cytokine, 2004 Jul 21-Aug 7. PMID 15242693

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Erythroid Differentiation Regulator 1 Strengthens TCR Signaling by Enhancing PLCgamma1 Signal Transduction Pathway.
      Title: Erythroid Differentiation Regulator 1 Strengthens TCR Signaling by Enhancing PLCγ1 Signal Transduction Pathway.
    2. Erythroid differentiation regulator 1 promotes wound healing by inducing the production of CC motif chemokine ligand 2 via the activation of MAP kinases in vitro and in vivo.
      Title: Erythroid differentiation regulator 1 promotes wound healing by inducing the production of C‑C motif chemokine ligand 2 via the activation of MAP kinases in vitro and in vivo.
    3. early-life microbiota controls Erdr1-mediated intestinal epithelial proliferation and regeneration in response to mucosal damage.
      Title: Erythroid differentiation regulator-1 induced by microbiota in early life drives intestinal stem cell proliferation and regeneration.
    4. Erdr1 is suppressed by the microbiota via Toll-like receptor signaling and MyD88 dependent pathways.[review]
      Title: Commensal regulation of T cell survival through Erdr1.
    5. autocrine factor that controls T-cell survival and has critical functions during homeostasis, inflammation, and autoimmunity
      Title: Microbiota promotes systemic T-cell survival through suppression of an apoptotic factor.
    6. increases after treatment of psoriasis
      Title: Downregulation of erythroid differentiation regulator 1 (Erdr1) plays a critical role in psoriasis pathogenesis.
    7. Erdr1 induced murine melanoma apoptosis through the regulation of Bcl-2 and Bax.
      Title: Erdr1 Suppresses Murine Melanoma Growth via Regulation of Apoptosis.
    8. Results show that ERDR1 is a stromal-derived factor that promotes cancer cell survival in vitro and in an experimental metastasis model.
      Title: C-C chemokine receptor 5 on pulmonary mesenchymal cells promotes experimental metastasis via the induction of erythroid differentiation regulator 1.
    9. Erdr1 shows a powerful anti-metastasis effect that leads to the ability to reduce the metastatic potential of murine malignant melanoma cells
      Title: Erythroid differentiation regulator 1, an interleukin 18-regulated gene, acts as a metastasis suppressor in melanoma.
    10. Expression was observed in many normal mouse tissues, yet in haematopoiesis it was largely confined to CD34+ cells
      Title: Erythroid differentiation regulator (EDR), a novel, highly conserved factor I. Induction of haemoglobin synthesis in erythroleukaemic cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 

    General gene information

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    Markers

    Clone Names

    • MGC5764

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of cell migration IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within somatic stem cell population maintenance IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    erythroid differentiation regulator 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133362.2 → NP_579940.1  erythroid differentiation regulator 1

      See identical proteins and their annotated locations for NP_579940.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1, coding) represents the functional allele that is not present in some strains.
      Source sequence(s)
      BC018296
      UniProtKB/TrEMBL
      O88727, Q8VEL1

    RNA

    1. NR_137282.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1, non-coding) represents the non-functional allele present in some strains, including the strain of the reference genome. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
      Source sequence(s)
      AC151712

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      168793522..168801793
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000087.8 Reference GRCm39 C57BL/6J

      Range
      90796711..90827734
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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