Elavl1 ELAV like RNA binding protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Elavl1provided by MGI
Official Full Name: ELAV like RNA binding protein 1provided by MGI
Primary source: MGI:MGI:1100851
See related: Ensembl:ENSMUSG00000040028 AllianceGenome:MGI:1100851
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: HUR; Hua; 2410055N02Rik
Summary: Enables long noncoding RNA binding activity and mRNA 3'-UTR AU-rich region binding activity. Involved in posttranscriptional regulation of gene expression; protein import into nucleus; and regulation of stem cell population maintenance. Acts upstream of or within positive regulation of translation. Located in several cellular components, including cytoplasmic stress granule; glutamatergic synapse; and postsynapse. Part of ribonucleoprotein complex. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and sensory organ. Orthologous to human ELAVL1 (ELAV like RNA binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 16.0), whole brain E14.5 (RPKM 14.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 A1.1; 8 2.0 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (4334781..4375104, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (4284781..4325140, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SUMOylation controls Hu antigen R posttranscriptional activity in liver cancer.
Title: SUMOylation controls Hu antigen R posttranscriptional activity in liver cancer.
HuR promotes castration-resistant prostate cancer progression by altering ERK5 activation via posttranscriptional regulation of BCAT1.
Title: HuR promotes castration-resistant prostate cancer progression by altering ERK5 activation via posttranscriptional regulation of BCAT1.
HuR-mediated nucleocytoplasmic translocation of HOTAIR relieves its inhibition of osteogenic differentiation and promotes bone formation.
Title: HuR-mediated nucleocytoplasmic translocation of HOTAIR relieves its inhibition of osteogenic differentiation and promotes bone formation.
Long noncoding RNA 1392 regulates MDA5 by interaction with ELAVL1 to inhibit coxsackievirus B5 infection.
Title: Long noncoding RNA 1392 regulates MDA5 by interaction with ELAVL1 to inhibit coxsackievirus B5 infection.
HuR modulation counteracts lipopolysaccharide response in murine macrophages.
Title: HuR modulation counteracts lipopolysaccharide response in murine macrophages.
The formation of HuR/YB1 complex is required for the stabilization of target mRNA to promote myogenesis.
Title: The formation of HuR/YB1 complex is required for the stabilization of target mRNA to promote myogenesis.
Down-regulation of HuR inhibits pathological angiogenesis in oxygen-induced retinopathy.
Title: Down-regulation of HuR inhibits pathological angiogenesis in oxygen-induced retinopathy.
Small noncoding vault RNA2-1 disrupts gut epithelial barrier function via interaction with HuR.
Title: Small noncoding vault RNA2-1 disrupts gut epithelial barrier function via interaction with HuR.
The RNA-Binding Protein HuR Is Integral to the Function of Nociceptors in Mice and Humans.
Title: The RNA-Binding Protein HuR Is Integral to the Function of Nociceptors in Mice and Humans.
HuR-dependent expression of Wisp1 is necessary for TGFbeta-induced cardiac myofibroblast activity.
Title: HuR-dependent expression of Wisp1 is necessary for TGFβ-induced cardiac myofibroblast activity.

Submit: New GeneRIF Correction See all GeneRIFs (137)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (10) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:225292

RH125305 (e-PCR)
- UniSTS:162127

UniSTS:498264 (e-PCR)
- UniSTS:498264

Elavl1 (e-PCR), detects polymorphism
- UniSTS:498264

BB284404 (e-PCR)
- UniSTS:208232

RH126821 (e-PCR)
- UniSTS:208233

AI481177 (e-PCR)
- UniSTS:179690

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	ISO Inferred from Sequence Orthology more info	PubMed
enables double-stranded RNA binding	ISO Inferred from Sequence Orthology more info	PubMed
enables lncRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables lncRNA binding	IPI Inferred from Physical Interaction more info	PubMed
enables mRNA 3'-UTR AU-rich region binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA 3'-UTR AU-rich region binding	ISO Inferred from Sequence Orthology more info	PubMed
enables mRNA 3'-UTR binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA 3'-UTR binding	ISO Inferred from Sequence Orthology more info
enables mRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA binding	ISO Inferred from Sequence Orthology more info
enables miRNA binding	ISO Inferred from Sequence Orthology more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in 3'-UTR-mediated mRNA stabilization	IDA Inferred from Direct Assay more info	PubMed
involved_in 3'-UTR-mediated mRNA stabilization	ISO Inferred from Sequence Orthology more info
involved_in mRNA destabilization	ISO Inferred from Sequence Orthology more info
involved_in mRNA stabilization	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within mRNA stabilization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA stabilization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mRNA stabilization	ISO Inferred from Sequence Orthology more info	PubMed
involved_in mRNA stabilization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of miRNA-mediated gene silencing	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of superoxide anion generation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of translation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of translation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of translation	ISO Inferred from Sequence Orthology more info	PubMed
involved_in post-transcriptional gene silencing	IDA Inferred from Direct Assay more info	PubMed
involved_in protein homooligomerization	ISO Inferred from Sequence Orthology more info
involved_in protein import into nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of translation	ISO Inferred from Sequence Orthology more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic stress granule	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasmic vesicle	IPI Inferred from Physical Interaction more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IEP Inferred from Expression Pattern more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynapse	IEP Inferred from Expression Pattern more info	PubMed
part_of ribonucleoprotein complex	IDA Inferred from Direct Assay more info	PubMed
located_in sarcoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: ELAV-like protein 1

Names: ELAV (embryonic lethal, abnormal vision)-like 1 (Hu antigen R); ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R); HU-antigen A; elav-like generic protein; hu-antigen R; melG

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010485.3 → NP_034615.2 ELAV-like protein 1

See identical proteins and their annotated locations for NP_034615.2

Status: VALIDATED

Source sequence(s)

AC155164, AK028769, AK080365, BB305633, BY775007

Consensus CDS

CCDS22084.1

UniProtKB/Swiss-Prot

P70372, Q60745, Q78QY3

UniProtKB/TrEMBL

Q3UFF9, Q8BM84, Q8BW03

Related

ENSMUSP00000096549.5, ENSMUST00000098950.6

Conserved Domains (1) summary

TIGR01661
Location:19 → 326

ELAV_HUD_SF; ELAV/HuD family splicing factor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

4334781..4375104 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006508698.5 → XP_006508761.1 ELAV-like protein 1 isoform X1

See identical proteins and their annotated locations for XP_006508761.1

UniProtKB/Swiss-Prot

P70372, Q60745, Q78QY3

UniProtKB/TrEMBL

Q3UFF9, Q8BM84, Q8BW03

Conserved Domains (1) summary

TIGR01661
Location:19 → 326

ELAV_HUD_SF; ELAV/HuD family splicing factor
XM_030243302.2 → XP_030099162.1 ELAV-like protein 1 isoform X1

UniProtKB/Swiss-Prot

P70372, Q60745, Q78QY3

UniProtKB/TrEMBL

Q3UFF9, Q8BM84, Q8BW03

Conserved Domains (1) summary

TIGR01661
Location:19 → 326

ELAV_HUD_SF; ELAV/HuD family splicing factor
XM_030243301.2 → XP_030099161.1 ELAV-like protein 1 isoform X1

UniProtKB/Swiss-Prot

P70372, Q60745, Q78QY3

UniProtKB/TrEMBL

Q3UFF9, Q8BM84, Q8BW03

Related

ENSMUSP00000146866.2, ENSMUST00000209010.2

Conserved Domains (1) summary

TIGR01661
Location:19 → 326

ELAV_HUD_SF; ELAV/HuD family splicing factor