Klf15 Kruppel-like transcription factor 15 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Klf15provided by MGI
Official Full Name: Kruppel-like transcription factor 15provided by MGI
Primary source: MGI:MGI:1929988
See related: Ensembl:ENSMUSG00000030087 AllianceGenome:MGI:1929988
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CKLF; KKLF; hlb444; 1810013I09Rik
Summary: Enables DNA-binding transcription factor activity and transcription cis-regulatory region binding activity. Involved in cardiac muscle hypertrophy in response to stress; glomerular visceral epithelial cell differentiation; and negative regulation of peptidyl-lysine acetylation. Acts upstream of or within several processes, including cellular glucose homeostasis; positive regulation of glucose import; and response to insulin. Located in nucleus. Is expressed in several structures, including central nervous system; cranium; early conceptus; metanephros; and nose. Used to study aortic aneurysm. Orthologous to human KLF15 (Kruppel like factor 15). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in liver adult (RPKM 36.3), kidney adult (RPKM 26.2) and 20 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6; 6 D1

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (90437785..90468785)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (90461043..90491803)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Macrophage KLF15 prevents foam cell formation and atherosclerosis via transcriptional suppression of OLR-1.
Title: Macrophage KLF15 prevents foam cell formation and atherosclerosis via transcriptional suppression of OLR-1.
Kruppel-like factor 15 deficiency exacerbates osteoarthritis through reduced expression of peroxisome proliferator-activated receptor gamma signaling in mice.
Title: Krüppel-like factor 15 deficiency exacerbates osteoarthritis through reduced expression of peroxisome proliferator-activated receptor gamma signaling in mice.
Kruppel-like Factor 15 Suppresses Ferroptosis by Activating an NRF2/GPX4 Signal to Protect against Folic Acid-Induced Acute Kidney Injury.
Title: Krüppel-like Factor 15 Suppresses Ferroptosis by Activating an NRF2/GPX4 Signal to Protect against Folic Acid-Induced Acute Kidney Injury.
The transcriptional regulator KLF15 is necessary for myoblast differentiation and muscle regeneration by activating FKBP5.
Title: The transcriptional regulator KLF15 is necessary for myoblast differentiation and muscle regeneration by activating FKBP5.
Sirtuin 7 mitigates renal ferroptosis, fibrosis and injury in hypertensive mice by facilitating the KLF15/Nrf2 signaling.
Title: Sirtuin 7 mitigates renal ferroptosis, fibrosis and injury in hypertensive mice by facilitating the KLF15/Nrf2 signaling.
Diallyl Trisulfide Prevents Adipogenesis and Lipogenesis by Regulating the Transcriptional Activation Function of KLF15 on PPARgamma to Ameliorate Obesity.
Title: Diallyl Trisulfide Prevents Adipogenesis and Lipogenesis by Regulating the Transcriptional Activation Function of KLF15 on PPARγ to Ameliorate Obesity.
Transcription factors KLF15 and PPARdelta cooperatively orchestrate genome-wide regulation of lipid metabolism in skeletal muscle.
Title: Transcription factors KLF15 and PPARδ cooperatively orchestrate genome-wide regulation of lipid metabolism in skeletal muscle.
CTRP12 alleviates cardiomyocyte ischemiareperfusion injury via regulation of KLF15.
Title: CTRP12 alleviates cardiomyocyte ischemia‑reperfusion injury via regulation of KLF15.
A Piezo1/KLF15/IL-6 axis mediates immobilization-induced muscle atrophy.
Title: A Piezo1/KLF15/IL-6 axis mediates immobilization-induced muscle atrophy.
KLF15 overexpression in myocytes fails to ameliorate ALS-related pathology or extend the lifespan of SOD1G93A mice.
Title: KLF15 overexpression in myocytes fails to ameliorate ALS-related pathology or extend the lifespan of SOD1G93A mice.

Submit: New GeneRIF Correction See all GeneRIFs (63)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Chemically induced (ENU) (1)
Endonuclease-mediated (5)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Klf15 (e-PCR), detects polymorphism
- UniSTS:468007

RH140732 (e-PCR)
- UniSTS:222798

Klf15 (e-PCR), detects polymorphism
- UniSTS:547446

AW494632 (e-PCR)
- UniSTS:179415

AV048136 (e-PCR)
- UniSTS:164331

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables transcription cis-regulatory region binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cardiac muscle hypertrophy in response to stress	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within glial cell differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within intracellular glucose homeostasis	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of peptidyl-lysine acetylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of peptidyl-lysine acetylation	ISO Inferred from Sequence Orthology more info
involved_in podocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of glucose import	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within response to insulin	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: Krueppel-like factor 15

Names: Kruppel-like factor 15; cardiovascular Krueppel-like factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001355668.1 → NP_001342597.1 Krueppel-like factor 15 isoform 2

Status: VALIDATED

Source sequence(s)

AC163346

Conserved Domains (2) summary

sd00017
Location:322 → 344

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:320 → 344

zf-C2H2; Zinc finger, C2H2 type
NM_023184.4 → NP_075673.1 Krueppel-like factor 15 isoform 1

See identical proteins and their annotated locations for NP_075673.1

Status: VALIDATED

Source sequence(s)

AC163346

Consensus CDS

CCDS20360.1

UniProtKB/Swiss-Prot

Q3UQB0, Q9EPW2

Related

ENSMUSP00000032174.6, ENSMUST00000032174.12

Conserved Domains (4) summary

sd00017
Location:322 → 344

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:320 → 344

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:366 → 391

zf-H2C2_2; Zinc-finger double domain

pfam15909
Location:322 → 401

zf-C2H2_8; C2H2-type zinc ribbon

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

90437785..90468785

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030255539.2 → XP_030111399.1 Krueppel-like factor 15 isoform X4

Conserved Domains (3) summary

sd00017
Location:322 → 344

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:320 → 344

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:336 → 358

zf-H2C2_2; Zinc-finger double domain
XM_006506472.4 → XP_006506535.1 Krueppel-like factor 15 isoform X2

Conserved Domains (3) summary

sd00017
Location:427 → 449

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:425 → 449

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:441 → 463

zf-H2C2_2; Zinc-finger double domain
XM_011241425.3 → XP_011239727.1 Krueppel-like factor 15 isoform X3

Conserved Domains (3) summary

sd00017
Location:427 → 449

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:425 → 449

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:441 → 463

zf-H2C2_2; Zinc-finger double domain
XM_006506471.4 → XP_006506534.1 Krueppel-like factor 15 isoform X1

Conserved Domains (3) summary

COG5189
Location:423 → 505

SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]

sd00017
Location:427 → 449

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:471 → 496

zf-H2C2_2; Zinc-finger double domain