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    Kctd20 potassium channel tetramerisation domain containing 20 [ Mus musculus (house mouse) ]

    Gene ID: 66989, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Kctd20provided by MGI
    Official Full Name
    potassium channel tetramerisation domain containing 20provided by MGI
    Primary source
    MGI:MGI:1914239
    See related
    Ensembl:ENSMUSG00000005936 AllianceGenome:MGI:1914239
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D17Ertd562e; 2410004N11Rik
    Summary
    Enables identical protein binding activity. Involved in positive regulation of phosphorylation. Located in cytoplasm. Is expressed in dorsal root ganglion; glossopharyngeal ganglion; medulla oblongata basal plate mantle layer; trigeminal ganglion; and vagus ganglion. Orthologous to human KCTD20 (potassium channel tetramerization domain containing 20). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 19.4), CNS E14 (RPKM 19.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    17 A3.3; 17 15.03 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (29171420..29188523)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (28952436..28969549)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700030A11 gene Neighboring gene BCL2 interacting protein 5 Neighboring gene STARR-seq mESC enhancer starr_42241 Neighboring gene predicted gene 16191 Neighboring gene peroxisomal, testis specific 1 Neighboring gene STARR-positive B cell enhancer ABC_E9948 Neighboring gene STARR-positive B cell enhancer ABC_E2477 Neighboring gene serine/threonine kinase 38 Neighboring gene predicted gene, 23887 Neighboring gene STARR-seq mESC enhancer starr_42244 Neighboring gene STARR-seq mESC enhancer starr_42246 Neighboring gene predicted gene 16196 Neighboring gene STARR-seq mESC enhancer starr_42249

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. KCTD20, a relative of BTBD10, is a positive regulator of Akt. Nawa M, et al. BMC Biochem, 2013 Oct 24. PMID 24156551, Free PMC Article
    2. Protein-protein interaction panel using mouse full-length cDNAs. Suzuki H, et al. Genome Res, 2001 Oct. PMID 11591653, Free PMC Article
    3. Lysosomal Signaling Licenses Embryonic Stem Cell Differentiation via Inactivation of Tfe3. Villegas F, et al. Cell Stem Cell, 2019 Feb 7. PMID 30595499
    4. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    5. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    BTB/POZ domain-containing protein KCTD20
    Names
    potassium channel tetramerization domain containing 20

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356298.2 → NP_001343227.2  BTB/POZ domain-containing protein KCTD20 isoform 3

      Status: VALIDATED

      Source sequence(s)
      CT025867
      Related
      ENSMUSP00000113740.2, ENSMUST00000117672.9
      Conserved Domains (2) summary
      cd18386
      Location:44 → 147
      BTB_POZ_KCTD20; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 20 (KCTD20)
      cl17171
      Location:209 → 248
      PH-like; Pleckstrin homology-like domain

    2. NM_001356299.2 → NP_001343228.1  BTB/POZ domain-containing protein KCTD20 isoform 3

      Status: VALIDATED

      Source sequence(s)
      CT025867
      Consensus CDS
      CCDS89045.1
      UniProtKB/TrEMBL
      Q5RKU8, Q80ZU2
      Related
      ENSMUSP00000112890.2, ENSMUST00000118762.9
      Conserved Domains (2) summary
      cd18386
      Location:44 → 147
      BTB_POZ_KCTD20; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 20 (KCTD20)
      cl17171
      Location:209 → 248
      PH-like; Pleckstrin homology-like domain

    3. NM_001356300.2 → NP_001343229.1  BTB/POZ domain-containing protein KCTD20 isoform 1

      Status: VALIDATED

      Source sequence(s)
      CT025867
      Consensus CDS
      CCDS28588.1
      UniProtKB/Swiss-Prot
      Q3TKH8, Q5U5Z7, Q8CDD8, Q9CSC4, Q9CWT1
      UniProtKB/TrEMBL
      A0A3F2YNM3
      Related
      ENSMUSP00000156936.2, ENSMUST00000233197.2
      Conserved Domains (2) summary
      cd18386
      Location:115 → 218
      BTB_POZ_KCTD20; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 20 (KCTD20)
      cl17171
      Location:280 → 319
      PH-like; Pleckstrin homology-like domain

    4. NM_025888.7 → NP_080164.2  BTB/POZ domain-containing protein KCTD20 isoform 1

      See identical proteins and their annotated locations for NP_080164.2

      Status: VALIDATED

      Source sequence(s)
      CT025867
      Consensus CDS
      CCDS28588.1
      UniProtKB/Swiss-Prot
      Q3TKH8, Q5U5Z7, Q8CDD8, Q9CSC4, Q9CWT1
      UniProtKB/TrEMBL
      A0A3F2YNM3
      Related
      ENSMUSP00000131435.2, ENSMUST00000168507.2
      Conserved Domains (2) summary
      cd18386
      Location:115 → 218
      BTB_POZ_KCTD20; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 20 (KCTD20)
      cl17171
      Location:280 → 319
      PH-like; Pleckstrin homology-like domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      29171420..29188523
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006524811.1 → XP_006524874.1  BTB/POZ domain-containing protein KCTD20 isoform X1

      See identical proteins and their annotated locations for XP_006524874.1

      UniProtKB/Swiss-Prot
      Q3TKH8, Q5U5Z7, Q8CDD8, Q9CSC4, Q9CWT1
      UniProtKB/TrEMBL
      A0A3F2YNM3
      Conserved Domains (2) summary
      cd18386
      Location:115 → 218
      BTB_POZ_KCTD20; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 20 (KCTD20)
      cl17171
      Location:280 → 319
      PH-like; Pleckstrin homology-like domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CDD8.1 GenPept UniProtKB/Swiss-Prot:Q8CDD8

    Gene LinkOut

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