Loricrin loricrin cornified envelope precursor protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Loricrinprovided by MGI
Official Full Name: loricrin cornified envelope precursor proteinprovided by MGI
Primary source: MGI:MGI:96816
See related: Ensembl:ENSMUSG00000043165 AllianceGenome:MGI:96816
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Lor
Summary: A structural constituent of cytoskeleton and structural constituent of skin epidermis. Predicted to be involved in keratinocyte differentiation and peptide cross-linking. Predicted to act upstream of or within keratinization. Located in cornified envelope and cytoplasmic side of plasma membrane. Is expressed in several structures, including gut; male reproductive system; sensory organ; skin; and thymus. Orthologous to human LORICRIN (loricrin cornified envelope precursor protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward stomach adult (RPKM 762.9) See more
Orthologs: human all
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Genomic context

Location:: 3 F1; 3 40.14 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (91987578..91990447, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (92080271..92083142, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

this study shows that loricrin confers photoprotective function against UVB in corneocytes
Title: Loricrin Confers Photoprotective Function against UVB in Corneocytes.
the late cornified envelope 1 proteins are regulated by NRF2 and are compensatory components for loricrin as determined by their localization within the loricrin knockout cell envelope via immunoelectron microscopy
Title: Lce1 Family Members Are Nrf2-Target Genes that Are Induced to Compensate for the Loss of Loricrin.
Oct-6 and Oct-11 contribute to the regulation of loricrin gene transcription via interaction with AP-1 factors and Sp1/Sp3.
Title: The POU domain transcription factors Oct-6 and Oct-11 negatively regulate loricrin gene expression in keratinocytes: association with AP-1 and Sp1/Sp3.
In the absence of loricrin, S. aureus nasal colonisation was significantly impaired.
Title: Nasal colonisation by Staphylococcus aureus depends upon clumping factor B binding to the squamous epithelial cell envelope protein loricrin.
The decreased expression of epidermal growth factor receptor (EGFR), E-cadherin, occludin, and SIRT1 in the skin of Flg(ft) mice, compared with those in C57BL/6J mice, is reported.
Title: Reduced expression of epidermal growth factor receptor, E-cadherin, and occludin in the skin of flaky tail mice is due to filaggrin and loricrin deficiencies.
Skin biopsies from STAT6 transgenic mice were deficient in the expression and production of loricrin and involucrin.
Title: Loricrin and involucrin expression is down-regulated by Th2 cytokines through STAT-6.
nectin-1 plays a key role in the expression of loricrin in the epidermis
Title: Up-regulation of loricrin expression by cell adhesion molecule nectin-1 through Rap1-ERK signaling in keratinocytes.
YY1 contributes to specific loricrin gene expression in differentiated keratinocytes by suppression of its transcription in undifferentiated keratinocytes.
Title: Yin-yang 1 negatively regulates the differentiation-specific transcription of mouse loricrin gene in undifferentiated keratinocytes.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (1)

General gene information

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Markers

Lor (e-PCR), detects polymorphism
- UniSTS:143788

AI036317 (e-PCR)
- UniSTS:178884

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables structural constituent of cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
enables structural constituent of skin epidermis	IDA Inferred from Direct Assay more info	PubMed
enables structural constituent of skin epidermis	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within keratinization	IEA Inferred from Electronic Annotation more info
involved_in keratinocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in peptide cross-linking	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cornified envelope	IDA Inferred from Direct Assay more info	PubMed
located_in cornified envelope	IDA Inferred from Direct Assay more info	PubMed
located_in cornified envelope	ISO Inferred from Sequence Orthology more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info	PubMed
located_in cytoplasmic side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: loricrin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.