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    Angpt2 angiopoietin 2 [ Mus musculus (house mouse) ]

    Gene ID: 11601, updated on 11-Jul-2021

    Summary

    Official Symbol
    Angpt2provided by MGI
    Official Full Name
    angiopoietin 2provided by MGI
    Primary source
    MGI:MGI:1202890
    See related
    Ensembl:ENSMUSG00000031465
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    An; Ang; Ang2; Agpt2; Ang-2
    Summary
    This gene encodes an endothelial cell (EC)-derived regulator of angiogenesis and ligand for endothelial-specific receptor tyrosine kinase. The encoded protein acts as an anti-apoptotic factor for stressed ECs and a proapoptotic factor for resting ECs. [provided by RefSeq, Jan 2013]
    Expression
    Broad expression in placenta adult (RPKM 8.9), kidney adult (RPKM 5.7) and 19 other tissues See more
    Orthologs
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    Genomic context

    See Angpt2 in Genome Data Viewer
    Location:
    8 A1.3; 8 10.3 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (18740279..18791578, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (18690263..18741562, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (18691337..18741551, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene microcephaly, primary autosomal recessive 1 Neighboring gene predicted gene, 25763 Neighboring gene predicted gene 17149 Neighboring gene predicted gene, 53403 Neighboring gene 1-acylglycerol-3-phosphate O-acyltransferase 5 (lysophosphatidic acid acyltransferase, epsilon)

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (4)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables receptor antagonist activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables receptor tyrosine kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables receptor tyrosine kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables vascular endothelial growth factor receptor binding TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in Tie signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in Tie signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within Tie signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in Tie signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in angiogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within angiogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within blood vessel morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in blood vessel remodeling TAS
    Traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within endoderm development TAS
    Traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within gene expression ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in glomerulus vasculature development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in hemopoiesis TAS
    Traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within negative regulation of angiogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of blood vessel endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of cell-substrate adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of positive chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of angiogenesis TAS
    Traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within transmembrane receptor protein tyrosine kinase signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cell projection ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in collagen-containing extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular space HDA PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007426.4NP_031452.2  angiopoietin-2 precursor

      See identical proteins and their annotated locations for NP_031452.2

      Status: REVIEWED

      Source sequence(s)
      AC122206, BC138309, CJ182273, CN539462
      Consensus CDS
      CCDS22125.1
      UniProtKB/Swiss-Prot
      O35608
      UniProtKB/TrEMBL
      B9EHQ4
      Related
      ENSMUSP00000033846.6, ENSMUST00000033846.7
      Conserved Domains (2) summary
      smart00186
      Location:280494
      FBG; Fibrinogen-related domains (FReDs)
      cl23720
      Location:168226
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      18740279..18791578 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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