Mknk2 MAP kinase-interacting serine/threonine kinase 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mknk2provided by MGI
Official Full Name: MAP kinase-interacting serine/threonine kinase 2provided by MGI
Primary source: MGI:MGI:894279
See related: Ensembl:ENSMUSG00000020190 AllianceGenome:MGI:894279
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mnk2; Gprk7; 2010016G11Rik
Summary: The protein encoded by this gene is a serine/threonine-protein kinase, which is targeted by both the extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways. This enzyme targets several substrates including eukaryotic translation initiation factor 4E and mammalian target of rapamycin, which are negatively regulated by its phosphorylation. Null mutant mice do not exhibit developmental or reproductive defects. However, mice null for both this protein and mitogen-activated protein kinase-interacting serine/threonine protein kinase 1 have delayed tumor development in phosphatase and tensin homolog mutant mice, indicating an oncogenic function for this gene in tumor development. [provided by RefSeq, Oct 2014]
Expression: Broad expression in mammary gland adult (RPKM 326.2), subcutaneous fat pad adult (RPKM 252.6) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 C1; 10 39.72 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (80501152..80512264, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (80665318..80676293, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MiR-223-3p alleviates trigeminal neuropathic pain in the male mouse by targeting MKNK2 and MAPK/ERK signaling.
Title: MiR-223-3p alleviates trigeminal neuropathic pain in the male mouse by targeting MKNK2 and MAPK/ERK signaling.
MNK2-eIF4E axis promotes cardiac repair in the infarcted mouse heart by activating cyclin D1.
Title: MNK2-eIF4E axis promotes cardiac repair in the infarcted mouse heart by activating cyclin D1.
Inhibiting the MNK1/2-eIF4E axis impairs melanoma phenotype switching and potentiates antitumor immune responses.
Title: Inhibiting the MNK1/2-eIF4E axis impairs melanoma phenotype switching and potentiates antitumor immune responses.
Disabling MNK protein kinases promotes oxidative metabolism and protects against diet-induced obesity.
Title: Disabling MNK protein kinases promotes oxidative metabolism and protects against diet-induced obesity.
MAPK-interacting kinase 2 (MNK2) regulates adipocyte metabolism independently of its catalytic activity.
Title: MAPK-interacting kinase 2 (MNK2) regulates adipocyte metabolism independently of its catalytic activity.
MNK2 governs the macrophage antiinflammatory phenotype.
Title: MNK2 governs the macrophage antiinflammatory phenotype.
MNK2 plays a role in adipogenesis and/or lipogenesis and in macrophage biology
Title: MNK1 and MNK2 mediate adverse effects of high-fat feeding in distinct ways.
Data suggest that Mnk1 and Mnk2 regulate cell migration/wound healing, expression of vimentin, stability of vimentin protein, and binding of eIF4E (eukaryotic translation initiation factor 4E) and Cyfip1 (cytoplasmic FMR1 interacting protein 1).
Title: The MAP kinase-interacting kinases regulate cell migration, vimentin expression and eIF4E/CYFIP1 binding.
Mnk2a directly interacts with and translocates p38alpha-MAPK into the nucleus. Alternatively, Mnk2b does not activate p38-MAPK.
Title: Mnk2 alternative splicing modulates the p38-MAPK pathway and impacts Ras-induced transformation.
eIF4E phosphorylation is enhanced by Rapamycin, which activates Mnk2a
Title: Rapamycin enhances eIF4E phosphorylation by activating MAP kinase-interacting kinase 2a (Mnk2a).

Submit: New GeneRIF Correction See all GeneRIFs (18)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Mknk2 (e-PCR), detects polymorphism
- UniSTS:527422

BE097229 (e-PCR)
- UniSTS:244621

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IDA Inferred from Direct Assay more info	PubMed
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables calcium-dependent protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables calmodulin binding	IBA Inferred from Biological aspect of Ancestor more info
enables calmodulin-dependent protein kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in cellular response to arsenic-containing substance	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within extrinsic apoptotic signaling pathway in absence of ligand	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within extrinsic apoptotic signaling pathway in absence of ligand	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hemopoiesis	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in intracellular signal transduction	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-serine phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in protein autophosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of translation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: MAP kinase-interacting serine/threonine-protein kinase 2

Names: G protein-coupled receptor kinase 7; MAP kinase signal-integrating kinase 2

NP_067437.2

EC 2.7.11.1

XP_006513379.1

EC 2.7.11.1

XP_017169313.1

EC 2.7.11.1

XP_036011555.1

EC 2.7.11.1

XP_036011556.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001428628.1 → NP_001415557.1 MAP kinase-interacting serine/threonine-protein kinase 2 isoform a

Status: REVIEWED

Source sequence(s)

AC152410

UniProtKB/Swiss-Prot

O08606, Q75PY0, Q8CDB0, Q9D893
NM_001428629.1 → NP_001415558.1 MAP kinase-interacting serine/threonine-protein kinase 2 isoform b

Status: REVIEWED

Description

Transcript Variant: This variant (3), as well as variant 4, encodes isoform b.

Source sequence(s)

AC152410

UniProtKB/TrEMBL

A0A0R4IZX7
NM_001428630.1 → NP_001415559.1 MAP kinase-interacting serine/threonine-protein kinase 2 isoform b

Status: REVIEWED

Source sequence(s)

AC152410

UniProtKB/TrEMBL

A0A0R4IZX7
NM_021462.5 → NP_067437.2 MAP kinase-interacting serine/threonine-protein kinase 2 isoform a

See identical proteins and their annotated locations for NP_067437.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longer isoform (a). Variants 1 and 2 both encode the same isoform (a).

Source sequence(s)

AC152410

Consensus CDS

CCDS24030.2

UniProtKB/Swiss-Prot

O08606, Q75PY0, Q8CDB0, Q9D893

Related

ENSMUSP00000143508.2, ENSMUST00000200082.5

Conserved Domains (1) summary

cl21453
Location:81 → 368

PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

80501152..80512264 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006513316.3 → XP_006513379.1 MAP kinase-interacting serine/threonine-protein kinase 2 isoform X1

Conserved Domains (1) summary

cl21453
Location:81 → 368

PKc_like; Protein Kinases, catalytic domain
XM_036155662.1 → XP_036011555.1 MAP kinase-interacting serine/threonine-protein kinase 2 isoform X2

Related

ENSMUSP00000003433.7, ENSMUST00000003433.11

Conserved Domains (1) summary

cl21453
Location:34 → 321

PKc_like; Protein Kinases, catalytic domain
XM_036155663.1 → XP_036011556.1 MAP kinase-interacting serine/threonine-protein kinase 2 isoform X2

UniProtKB/TrEMBL

A0A0R4IZX7

Conserved Domains (1) summary

cl21453
Location:34 → 321

PKc_like; Protein Kinases, catalytic domain
XM_017313824.3 → XP_017169313.1 MAP kinase-interacting serine/threonine-protein kinase 2 isoform X2

Conserved Domains (1) summary

cl21453
Location:34 → 321

PKc_like; Protein Kinases, catalytic domain