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    Tnfrsf11b tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) [ Mus musculus (house mouse) ]

    Gene ID: 18383, updated on 3-Apr-2024

    Summary

    Official Symbol
    Tnfrsf11bprovided by MGI
    Official Full Name
    tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)provided by MGI
    Primary source
    MGI:MGI:109587
    See related
    Ensembl:ENSMUSG00000063727 AllianceGenome:MGI:109587
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Opg; TR1; OCIF
    Summary
    Acts upstream of or within extracellular matrix organization and negative regulation of odontogenesis of dentin-containing tooth. Located in extracellular matrix. Is expressed in several structures, including arterial system; bone; gut; lung; and placenta. Used to study osteoporosis. Human ortholog(s) of this gene implicated in Paget's disease of bone and osteoarthritis. Orthologous to human TNFRSF11B (TNF receptor superfamily member 11b). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in placenta adult (RPKM 3.7), liver E18 (RPKM 2.2) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Tnfrsf11b in Genome Data Viewer
    Location:
    15 D1; 15 21.15 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (54114014..54141700, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (54250619..54278484, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene sterile alpha motif domain containing 12 Neighboring gene microRNA 28c Neighboring gene STARR-seq mESC enhancer starr_38685 Neighboring gene predicted gene 7489 Neighboring gene STARR-seq mESC enhancer starr_38686 Neighboring gene ribosomal protein L19 pseudogene Neighboring gene predicted gene 5215

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables heparan sulfate binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in extracellular matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular region NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in extracellular space HDA PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    part_of receptor complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    tumor necrosis factor receptor superfamily member 11B
    Names
    osteoclastogenesis inhibitory factor
    osteoprotegerin

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001411506.1NP_001398435.1  tumor necrosis factor receptor superfamily member 11B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC121114
    2. NM_008764.4NP_032790.3  tumor necrosis factor receptor superfamily member 11B isoform 1 precursor

      See identical proteins and their annotated locations for NP_032790.3

      Status: VALIDATED

      Source sequence(s)
      AC121114
      Consensus CDS
      CCDS27468.1
      UniProtKB/Swiss-Prot
      O08712, O70202
      UniProtKB/TrEMBL
      Q3UK97, Q6PI12
      Related
      ENSMUSP00000078705.4, ENSMUST00000079772.4
      Conserved Domains (3) summary
      cd00185
      Location:122185
      TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
      cd10581
      Location:7151
      TNFRSF11B; Tumor necrosis factor receptor superfamily member 11B (TNFRSF11B), also known as Osteoprotegerin (OPG)
      pfam00531
      Location:293365
      Death; Death domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      54114014..54141700 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)